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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15660

FusionGeneSummary for GTF3C2_WDR35

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF3C2_WDR35
Fusion gene ID: 15660
HgeneTgene
Gene symbol

GTF3C2

WDR35

Gene ID

2976

57539

Gene namegeneral transcription factor IIIC subunit 2WD repeat domain 35
SynonymsTFIIIC-BETA|TFIIIC110CED2|IFT121|IFTA1|SRTD7
Cytomap

2p23.3

2p24.1

Type of geneprotein-codingprotein-coding
Descriptiongeneral transcription factor 3C polypeptide 2TF3C-betaTFIIIC 110 kDa subunitgeneral transcription factor IIIC, polypeptide 2, beta 110kDatranscription factor IIIC 110 kDa subunittranscription factor IIIC subunit betaWD repeat-containing protein 35intraflagellar transport protein 121 homolognaofen
Modification date2018052320180523
UniProtAcc

Q8WUA4

Q9P2L0

Ensembl transtripts involved in fusion geneENST00000359541, ENST00000264720, 
ENST00000281405, ENST00000345530, 
ENST00000416055, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GTF3C2 [Title/Abstract] AND WDR35 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGTF3C2

GO:0006351

transcription, DNA-templated

17409385

HgeneGTF3C2

GO:0006383

transcription by RNA polymerase III

17409385


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A0A7-01AGTF3C2chr2

27564815

-WDR35chr2

20160375

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000359541ENST00000281405GTF3C2chr2

27564815

-WDR35chr2

20160375

-
Frame-shiftENST00000359541ENST00000345530GTF3C2chr2

27564815

-WDR35chr2

20160375

-
5CDS-intronENST00000359541ENST00000416055GTF3C2chr2

27564815

-WDR35chr2

20160375

-
Frame-shiftENST00000264720ENST00000281405GTF3C2chr2

27564815

-WDR35chr2

20160375

-
Frame-shiftENST00000264720ENST00000345530GTF3C2chr2

27564815

-WDR35chr2

20160375

-
5CDS-intronENST00000264720ENST00000416055GTF3C2chr2

27564815

-WDR35chr2

20160375

-

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FusionProtFeatures for GTF3C2_WDR35


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GTF3C2

Q8WUA4

WDR35

Q9P2L0

Required for RNA polymerase III-mediated transcription.Component of TFIIIC that initiates transcription complex assemblyon tRNA and is required for transcription of 5S rRNA and otherstable nuclear and cytoplasmic RNAs. May play a direct role instabilizing interactions of TFIIIC2 with TFIIIC1. Component of the IFT complex A (IFT-A), a complexrequired for retrograde ciliary transport. Required forciliogenesis. May promote CASP3 activation and TNF-stimulatedapoptosis. {ECO:0000269|PubMed:20193664,ECO:0000269|PubMed:21473986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GTF3C2_WDR35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GTF3C2_WDR35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GTF3C2GTF3C3, GTF3C5, TBP, POLR3C, GTF3C4, EP300, MYC, SMARCAD1, GTF3C1, GTF3C6, GRIA2, RPA3, RPA2, RPA1, PASK, RPL13, STX6, RPS2, FBL, CASQ2, NTRK1, RB1, HIST1H2BG, HERC2, AHSA1, PAEP, RPL10, AURKA, SYN1, GPSM2, FOXB1, FBXW7, FOXQ1, FOXS1, POU5F1, TRAF3IP1, ZNF496, ZNF638, SDC2, ZNF785, C1QBP, ZNF579, CD44, RBM27, BAG1, PNMA5, ZNF764, RBM26, CPNE4, LSM14B, CLEC3A, DDX51, PRR20E, NEUROG3, DDX50, USP15, SPAG9, MCM2, MCM4, TRIM25WDR35BCL6, ALYREF, CUL3, C11orf74, IFT122, NTRK1, KIF2A, MAD2L1, PCNT, AURKA, RNPS1, SGTB, ZSCAN26, IFT43, TULP3, TULP2, DNAJC7, WDR19, IFT140, TTC21B, NTPCR, NUDC, NEK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GTF3C2_WDR35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GTF3C2_WDR35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDR35C0010278Craniosynostosis1CTD_human
TgeneWDR35C3150874CRANIOECTODERMAL DYSPLASIA 21CTD_human;UNIPROT
TgeneWDR35C3279792SHORT-RIB THORACIC DYSPLASIA 7 WITH OR WITHOUT POLYDACTYLY1UNIPROT