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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15630

FusionGeneSummary for GTF2F2_S100A4

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF2F2_S100A4
Fusion gene ID: 15630
HgeneTgene
Gene symbol

GTF2F2

S100A4

Gene ID

2963

6275

Gene namegeneral transcription factor IIF subunit 2S100 calcium binding protein A4
SynonymsBTF4|RAP30|TF2F2|TFIIF18A2|42A|CAPL|FSP1|MTS1|P9KA|PEL98
Cytomap

13q14.12-q14.13

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiongeneral transcription factor IIF subunit 2ATP-dependent helicase GTF2F2TFIIF-betageneral transcription factor IIF 30 kDa subunitgeneral transcription factor IIF, polypeptide 2, 30kDatranscription initiation factor IIF subunit betatranscription initiprotein S100-A4S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)calcium placental proteinfibroblast-specific protein-1leukemia multidrug resistance associated proteinmalignant transformation suppress
Modification date2018052320180522
UniProtAcc

P13984

P26447

Ensembl transtripts involved in fusion geneENST00000340473, ENST00000494087, 
ENST00000368715, ENST00000481009, 
ENST00000354332, ENST00000368716, 
ENST00000368714, 
Fusion gene scores* DoF score8 X 4 X 6=1923 X 2 X 2=12
# samples 73
** MAII scorelog2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GTF2F2 [Title/Abstract] AND S100A4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneS100A4

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

15033494


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A1AD-01AGTF2F2chr13

45694856

+S100A4chr1

153517285

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340473ENST00000368715GTF2F2chr13

45694856

+S100A4chr1

153517285

-
5CDS-5UTRENST00000340473ENST00000481009GTF2F2chr13

45694856

+S100A4chr1

153517285

-
5CDS-5UTRENST00000340473ENST00000354332GTF2F2chr13

45694856

+S100A4chr1

153517285

-
5CDS-5UTRENST00000340473ENST00000368716GTF2F2chr13

45694856

+S100A4chr1

153517285

-
5CDS-5UTRENST00000340473ENST00000368714GTF2F2chr13

45694856

+S100A4chr1

153517285

-
intron-5UTRENST00000494087ENST00000368715GTF2F2chr13

45694856

+S100A4chr1

153517285

-
intron-5UTRENST00000494087ENST00000481009GTF2F2chr13

45694856

+S100A4chr1

153517285

-
intron-5UTRENST00000494087ENST00000354332GTF2F2chr13

45694856

+S100A4chr1

153517285

-
intron-5UTRENST00000494087ENST00000368716GTF2F2chr13

45694856

+S100A4chr1

153517285

-
intron-5UTRENST00000494087ENST00000368714GTF2F2chr13

45694856

+S100A4chr1

153517285

-

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FusionProtFeatures for GTF2F2_S100A4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GTF2F2

P13984

S100A4

P26447

TFIIF is a general transcription initiation factor thatbinds to RNA polymerase II and helps to recruit it to theinitiation complex in collaboration with TFIIB. It promotestranscription elongation. This subunit shows ATP-dependent DNA-helicase activity. {ECO:0000269|PubMed:2477704}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GTF2F2_S100A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GTF2F2_S100A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GTF2F2GTF2B, HTATSF1, GTF2E1, TBP, AHR, ARNT, FOS, JUN, POLR2E, MSX2, ATF4, TCEA1, GTF2E2, AR, POLR2A, POLR2B, POLR2J, POLR2G, POLR2H, CTDP1, BAG6, MED29, SUPT5H, GPRC5A, POLR2C, GTF2F1, TAF10, TAF5, TAF4, HMGA1, LMNA, RPL27A, TCTEX1D2, HECW2, EFTUD2, SH3GL1, SHMT1, FAM177A1, UBR5, SRRT, SUPT4H1, NTRK1, KLF5, EWSR1, XPO1, POLR2F, CBLN4, TMEM184AS100A4S100A1, BAG6, UNC119, TP53, PPFIBP1, H2AFX, MDM2, SMAD3, SMAD2, IGBP1, TOM1L2, UNK, SUGT1, PSMA1, SELENBP1, SNRPF, TRIP13, ZZEF1, CEP76, S100B, MOV10, NXF1, EGFR, HSPB1, SRPK2, XIAP, IGHG3, NPAT, CDK2, NR2C2, PHF12, S100A6, SUV39H1, DYNLL1, DNAJA3, DNAJB6, POP4, CNTRL, KAT7, WDFY3, SYNE2, BRD1, UQCR10, BBX, CORO7, PTGR2, ESCO2, RHOU, RHOA, NOV


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GTF2F2_S100A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneS100A4P26447DB00831TrifluoperazineProtein S100-A4small moleculeapproved|investigational

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RelatedDiseases for GTF2F2_S100A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneS100A4C0027627Neoplasm Metastasis2CTD_human
TgeneS100A4C0009375Colonic Neoplasms1CTD_human
TgeneS100A4C0022116Ischemia1CTD_human
TgeneS100A4C0022548Keloid1CTD_human
TgeneS100A4C0025149Medulloblastoma1CTD_human
TgeneS100A4C0027626Neoplasm Invasiveness1CTD_human
TgeneS100A4C0029408Degenerative polyarthritis1CTD_human
TgeneS100A4C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneS100A4C0751895Vasospasm, Intracranial1CTD_human