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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 1562

FusionGeneSummary for ALK_SCEL

check button Fusion gene summary
Fusion gene informationFusion gene name: ALK_SCEL
Fusion gene ID: 1562
HgeneTgene
Gene symbol

ALK

SCEL

Gene ID

238

8796

Gene nameALK receptor tyrosine kinasesciellin
SynonymsCD246|NBLST3-
Cytomap

2p23.2-p23.1

13q22.3

Type of geneprotein-codingprotein-coding
DescriptionALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinasesciellin
Modification date2018052720180519
UniProtAcc

Q9UM73

O95171

Ensembl transtripts involved in fusion geneENST00000389048, ENST00000431873, 
ENST00000498037, 		ENST00000535157, 
ENST00000377246, ENST00000349847, 
ENST00000469982, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 3=27
# samples 63
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ALK [Title/Abstract] AND SCEL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALK

GO:0016310

phosphorylation

9174053

HgeneALK

GO:0046777

protein autophosphorylation

9174053

TgeneSCEL

GO:0030216

keratinocyte differentiation

14632196


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-EO-A3AS-01AALKchr2

29754781

-SCELchr13

78202082

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389048ENST00000535157ALKchr2

29754781

-SCELchr13

78202082

+
In-frameENST00000389048ENST00000377246ALKchr2

29754781

-SCELchr13

78202082

+
In-frameENST00000389048ENST00000349847ALKchr2

29754781

-SCELchr13

78202082

+
5CDS-intronENST00000389048ENST00000469982ALKchr2

29754781

-SCELchr13

78202082

+
intron-3CDSENST00000431873ENST00000535157ALKchr2

29754781

-SCELchr13

78202082

+
intron-3CDSENST00000431873ENST00000377246ALKchr2

29754781

-SCELchr13

78202082

+
intron-3CDSENST00000431873ENST00000349847ALKchr2

29754781

-SCELchr13

78202082

+
intron-intronENST00000431873ENST00000469982ALKchr2

29754781

-SCELchr13

78202082

+
intron-3CDSENST00000498037ENST00000535157ALKchr2

29754781

-SCELchr13

78202082

+
intron-3CDSENST00000498037ENST00000377246ALKchr2

29754781

-SCELchr13

78202082

+
intron-3CDSENST00000498037ENST00000349847ALKchr2

29754781

-SCELchr13

78202082

+
intron-intronENST00000498037ENST00000469982ALKchr2

29754781

-SCELchr13

78202082

+

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FusionProtFeatures for ALK_SCEL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALK

Q9UM73

SCEL

O95171

Neuronal receptor tyrosine kinase that is essentiallyand transiently expressed in specific regions of the central andperipheral nervous systems and plays an important role in thegenesis and differentiation of the nervous system. Transducessignals from ligands at the cell surface, through specificactivation of the mitogen-activated protein kinase (MAPK) pathway.Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK inducestyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well asof the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptorfor ligands pleiotrophin (PTN), a secreted growth factor, andmidkine (MDK), a PTN-related factor, thus participating in PTN andMDK signal transduction. PTN-binding induces MAPK pathwayactivation, which is important for the anti-apoptotic signaling ofPTN and regulation of cell proliferation. MDK-binding inducesphosphorylation of the ALK target insulin receptor substrate(IRS1), activates mitogen-activated protein kinases (MAPKs) andPI3-kinase, resulting also in cell proliferation induction. DrivesNF-kappa-B activation, probably through IRS1 and the activation ofthe AKT serine/threonine kinase. Recruitment of IRS1 to activatedALK and the activation of NF-kappa-B are essential for theautocrine growth and survival signaling of MDK.{ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720,ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760,ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009,ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:15908427,ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150,ECO:0000269|PubMed:17274988}. May function in the assembly or regulation of proteinsin the cornified envelope. The LIM domain may be involved inhomotypic or heterotypic associations and may function to localizesciellin to the cornified envelope.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633619_685542689DomainLIM zinc-binding
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532619_685522669DomainLIM zinc-binding
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431619_685500647DomainLIM zinc-binding
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633544_563542689RepeatNote=16
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532524_543522669RepeatNote=15
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532544_563522669RepeatNote=16
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431505_523500647RepeatNote=14
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431524_543500647RepeatNote=15
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431544_563500647RepeatNote=16

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALKchr2:29754781chr13:78202082ENST00000389048-429816_9403841621Compositional biasNote=Gly-rich
HgeneALKchr2:29754781chr13:78202082ENST00000389048-4291116_13923841621DomainProtein kinase
HgeneALKchr2:29754781chr13:78202082ENST00000389048-429264_4273841621DomainMAM 1
HgeneALKchr2:29754781chr13:78202082ENST00000389048-429437_4733841621DomainNote=LDL-receptor class A
HgeneALKchr2:29754781chr13:78202082ENST00000389048-429478_6363841621DomainMAM 2
HgeneALKchr2:29754781chr13:78202082ENST00000389048-4291197_11993841621RegionNote=Inhibitor binding
HgeneALKchr2:29754781chr13:78202082ENST00000389048-4291060_16203841621Topological domainCytoplasmic
HgeneALKchr2:29754781chr13:78202082ENST00000389048-42919_10383841621Topological domainExtracellular
HgeneALKchr2:29754781chr13:78202082ENST00000389048-4291039_10593841621TransmembraneHelical
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633251_563542689RegionNote=16 X approximate tandem repeats
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532251_563522669RegionNote=16 X approximate tandem repeats
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431251_563500647RegionNote=16 X approximate tandem repeats
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633251_266542689RepeatNote=1
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633267_286542689RepeatNote=2
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633287_306542689RepeatNote=3
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633307_326542689RepeatNote=4
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633327_346542689RepeatNote=5
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633347_366542689RepeatNote=6
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633387_406542689RepeatNote=8
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633407_426542689RepeatNote=9
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633427_446542689RepeatNote=10
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633447_465542689RepeatNote=11
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633466_484542689RepeatNote=12
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633485_504542689RepeatNote=13
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633505_523542689RepeatNote=14
TgeneSCELchr2:29754781chr13:78202082ENST00000349847+2633524_543542689RepeatNote=15
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532251_266522669RepeatNote=1
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532267_286522669RepeatNote=2
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532287_306522669RepeatNote=3
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532307_326522669RepeatNote=4
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532327_346522669RepeatNote=5
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532347_366522669RepeatNote=6
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532387_406522669RepeatNote=8
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532407_426522669RepeatNote=9
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532427_446522669RepeatNote=10
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532447_465522669RepeatNote=11
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532466_484522669RepeatNote=12
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532485_504522669RepeatNote=13
TgeneSCELchr2:29754781chr13:78202082ENST00000377246+2532505_523522669RepeatNote=14
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431251_266500647RepeatNote=1
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431267_286500647RepeatNote=2
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431287_306500647RepeatNote=3
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431307_326500647RepeatNote=4
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431327_346500647RepeatNote=5
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431347_366500647RepeatNote=6
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431387_406500647RepeatNote=8
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431407_426500647RepeatNote=9
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431427_446500647RepeatNote=10
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431447_465500647RepeatNote=11
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431466_484500647RepeatNote=12
TgeneSCELchr2:29754781chr13:78202082ENST00000535157+2431485_504500647RepeatNote=13


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FusionGeneSequence for ALK_SCEL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000535157_chr13_78202082_+_531aa
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGS
LALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDF
PCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
YIAQLLPHNEAAREILLMPTPGKHGDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVY

>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000377246_chr13_78202082_+_531aa
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGS
LALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDF
PCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
YIAQLLPHNEAAREILLMPTPGKHGDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVY

>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000349847_chr13_78202082_+_531aa
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGS
LALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDF
PCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
YIAQLLPHNEAAREILLMPTPGKHGDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000535157_chr13_78202082_+_1593nt
ATGGGAGCCATCGGGCTCCTGTGGCTCCTGCCGCTGCTGCTTTCCACGGCAGCTGTGGGCTCCGGGATGGGGACCGGCCAGCGCGCGGGC
TCCCCAGCTGCGGGGCCGCCGCTGCAGCCCCGGGAGCCACTCAGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCAGTTGACTTCGTGGTG
CCCTCGCTCTTCCGTGTCTACGCCCGGGACCTACTGCTGCCACCATCCTCCTCGGAGCTGAAGGCTGGCAGGCCCGAGGCCCGCGGCTCG
CTAGCTCTGGACTGCGCCCCGCTGCTCAGGTTGCTGGGGCCGGCGCCGGGGGTCTCCTGGACCGCCGGTTCACCAGCCCCGGCAGAGGCC
CGGACGCTGTCCAGGGTGCTGAAGGGCGGCTCCGTGCGCAAGCTCCGGCGTGCCAAGCAGTTGGTGCTGGAGCTGGGCGAGGAGGCGATC
TTGGAGGGTTGCGTCGGGCCCCCCGGGGAGGCGGCTGTGGGGCTGCTCCAGTTCAATCTCAGCGAGCTGTTCAGTTGGTGGATTCGCCAA
GGCGAAGGGCGACTGAGGATCCGCCTGATGCCCGAGAAGAAGGCGTCGGAAGTGGGCAGAGAGGGAAGGCTGTCCGCGGCAATTCGCGCC
TCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACTGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTAT
TTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTTTGACTTC
CCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAG
ATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGACTCCAAG
CACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTCTGGAAGG
TACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGAGACCAGAACCTGGAA
AATTTAATTGAAGTAAATTCTCATGTGTCTGAAAACAAGAATGGAAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGATACTGTT
GTGTACACAAGGACATATGTGGAGAATAGTAAATCACCCAAGGATGGATATCAGGAGAATATCTCTGGAAAATACATACAAACTGTTTAT
TCAACTTCTGATAGGTCTGTCATTGAAAGAGATATGTGCACTTACTGCCGAAAACCCTTGGGTGTAGAAACTAAAATGATTTTAGATGAA
TTACAAATTTGCTGCCATTCTACTTGCTTTAAGTGTGAAATATGCAAGCAGCCTTTGGAAAATCTACAAGCGGGTGATAGTATTTGGATT

>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000377246_chr13_78202082_+_1593nt
ATGGGAGCCATCGGGCTCCTGTGGCTCCTGCCGCTGCTGCTTTCCACGGCAGCTGTGGGCTCCGGGATGGGGACCGGCCAGCGCGCGGGC
TCCCCAGCTGCGGGGCCGCCGCTGCAGCCCCGGGAGCCACTCAGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCAGTTGACTTCGTGGTG
CCCTCGCTCTTCCGTGTCTACGCCCGGGACCTACTGCTGCCACCATCCTCCTCGGAGCTGAAGGCTGGCAGGCCCGAGGCCCGCGGCTCG
CTAGCTCTGGACTGCGCCCCGCTGCTCAGGTTGCTGGGGCCGGCGCCGGGGGTCTCCTGGACCGCCGGTTCACCAGCCCCGGCAGAGGCC
CGGACGCTGTCCAGGGTGCTGAAGGGCGGCTCCGTGCGCAAGCTCCGGCGTGCCAAGCAGTTGGTGCTGGAGCTGGGCGAGGAGGCGATC
TTGGAGGGTTGCGTCGGGCCCCCCGGGGAGGCGGCTGTGGGGCTGCTCCAGTTCAATCTCAGCGAGCTGTTCAGTTGGTGGATTCGCCAA
GGCGAAGGGCGACTGAGGATCCGCCTGATGCCCGAGAAGAAGGCGTCGGAAGTGGGCAGAGAGGGAAGGCTGTCCGCGGCAATTCGCGCC
TCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACTGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTAT
TTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTTTGACTTC
CCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAG
ATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGACTCCAAG
CACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTCTGGAAGG
TACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGAGACCAGAACCTGGAA
AATTTAATTGAAGTAAATTCTCATGTGTCTGAAAACAAGAATGGAAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGATACTGTT
GTGTACACAAGGACATATGTGGAGAATAGTAAATCACCCAAGGATGGATATCAGGAGAATATCTCTGGAAAATACATACAAACTGTTTAT
TCAACTTCTGATAGGTCTGTCATTGAAAGAGATATGTGCACTTACTGCCGAAAACCCTTGGGTGTAGAAACTAAAATGATTTTAGATGAA
TTACAAATTTGCTGCCATTCTACTTGCTTTAAGTGTGAAATATGCAAGCAGCCTTTGGAAAATCTACAAGCGGGTGATAGTATTTGGATT

>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000349847_chr13_78202082_+_1593nt
ATGGGAGCCATCGGGCTCCTGTGGCTCCTGCCGCTGCTGCTTTCCACGGCAGCTGTGGGCTCCGGGATGGGGACCGGCCAGCGCGCGGGC
TCCCCAGCTGCGGGGCCGCCGCTGCAGCCCCGGGAGCCACTCAGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCAGTTGACTTCGTGGTG
CCCTCGCTCTTCCGTGTCTACGCCCGGGACCTACTGCTGCCACCATCCTCCTCGGAGCTGAAGGCTGGCAGGCCCGAGGCCCGCGGCTCG
CTAGCTCTGGACTGCGCCCCGCTGCTCAGGTTGCTGGGGCCGGCGCCGGGGGTCTCCTGGACCGCCGGTTCACCAGCCCCGGCAGAGGCC
CGGACGCTGTCCAGGGTGCTGAAGGGCGGCTCCGTGCGCAAGCTCCGGCGTGCCAAGCAGTTGGTGCTGGAGCTGGGCGAGGAGGCGATC
TTGGAGGGTTGCGTCGGGCCCCCCGGGGAGGCGGCTGTGGGGCTGCTCCAGTTCAATCTCAGCGAGCTGTTCAGTTGGTGGATTCGCCAA
GGCGAAGGGCGACTGAGGATCCGCCTGATGCCCGAGAAGAAGGCGTCGGAAGTGGGCAGAGAGGGAAGGCTGTCCGCGGCAATTCGCGCC
TCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACTGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTAT
TTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTTTGACTTC
CCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAG
ATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGACTCCAAG
CACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTCTGGAAGG
TACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGAGACCAGAACCTGGAA
AATTTAATTGAAGTAAATTCTCATGTGTCTGAAAACAAGAATGGAAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGATACTGTT
GTGTACACAAGGACATATGTGGAGAATAGTAAATCACCCAAGGATGGATATCAGGAGAATATCTCTGGAAAATACATACAAACTGTTTAT
TCAACTTCTGATAGGTCTGTCATTGAAAGAGATATGTGCACTTACTGCCGAAAACCCTTGGGTGTAGAAACTAAAATGATTTTAGATGAA
TTACAAATTTGCTGCCATTCTACTTGCTTTAAGTGTGAAATATGCAAGCAGCCTTTGGAAAATCTACAAGCGGGTGATAGTATTTGGATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000535157_chr13_78202082_+_3485nt
GGGGGCGGCAGCGGTGGTAGCAGCTGGTACCTCCCGCCGCCTCTGTTCGGAGGGTCGCGGGGCACCGAGGTGCTTTCCGGCCGCCCTCTG
GTCGGCCACCCAAAGCCGCGGGCGCTGATGATGGGTGAGGAGGGGGCGGCAAGATTTCGGGCGCCCCTGCCCTGAACGCCCTCAGCTGCT
GCCGCCGGGGCCGCTCCAGTGCCTGCGAACTCTGAGGAGCCGAGGCGCCGGTGAGAGCAAGGACGCTGCAAACTTGCGCAGCGCGGGGGC
TGGGATTCACGCCCAGAAGTTCAGCAGGCAGACAGTCCGAAGCCTTCCCGCAGCGGAGAGATAGCTTGAGGGTGCGCAAGACGGCAGCCT
CCGCCCTCGGTTCCCGCCCAGACCGGGCAGAAGAGCTTGGAGGAGCCAAAAGGAACGCAAAAGGCGGCCAGGACAGCGTGCAGCAGCTGG
GAGCCGCCGTTCTCAGCCTTAAAAGTTGCAGAGATTGGAGGCTGCCCCGAGAGGGGACAGACCCCAGCTCCGACTGCGGGGGGCAGGAGA
GGACGGTACCCAACTGCCACCTCCCTTCAACCATAGTAGTTCCTCTGTACCGAGCGCAGCGAGCTACAGACGGGGGCGCGGCACTCGGCG
CGGAGAGCGGGAGGCTCAAGGTCCCAGCCAGTGAGCCCAGTGTGCTTGAGTGTCTCTGGACTCGCCCCTGAGCTTCCAGGTCTGTTTCAT
TTAGACTCCTGCTCGCCTCCGTGCAGTTGGGGGAAAGCAAGAGACTTGCGCGCACGCACAGTCCTCTGGAGATCAGGTGGAAGGAGCCGC
TGGGTACCAAGGACTGTTCAGAGCCTCTTCCCATCTCGGGGAGAGCGAAGGGTGAGGCTGGGCCCGGAGAGCAGTGTAAACGGCCTCCTC
CGGCGGGATGGGAGCCATCGGGCTCCTGTGGCTCCTGCCGCTGCTGCTTTCCACGGCAGCTGTGGGCTCCGGGATGGGGACCGGCCAGCG
CGCGGGCTCCCCAGCTGCGGGGCCGCCGCTGCAGCCCCGGGAGCCACTCAGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCAGTTGACTT
CGTGGTGCCCTCGCTCTTCCGTGTCTACGCCCGGGACCTACTGCTGCCACCATCCTCCTCGGAGCTGAAGGCTGGCAGGCCCGAGGCCCG
CGGCTCGCTAGCTCTGGACTGCGCCCCGCTGCTCAGGTTGCTGGGGCCGGCGCCGGGGGTCTCCTGGACCGCCGGTTCACCAGCCCCGGC
AGAGGCCCGGACGCTGTCCAGGGTGCTGAAGGGCGGCTCCGTGCGCAAGCTCCGGCGTGCCAAGCAGTTGGTGCTGGAGCTGGGCGAGGA
GGCGATCTTGGAGGGTTGCGTCGGGCCCCCCGGGGAGGCGGCTGTGGGGCTGCTCCAGTTCAATCTCAGCGAGCTGTTCAGTTGGTGGAT
TCGCCAAGGCGAAGGGCGACTGAGGATCCGCCTGATGCCCGAGAAGAAGGCGTCGGAAGTGGGCAGAGAGGGAAGGCTGTCCGCGGCAAT
TCGCGCCTCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACTGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCC
TGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTT
TGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGC
CTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGA
CTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTC
TGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGAGACCAGAA
CCTGGAAAATTTAATTGAAGTAAATTCTCATGTGTCTGAAAACAAGAATGGAAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGA
TACTGTTGTGTACACAAGGACATATGTGGAGAATAGTAAATCACCCAAGGATGGATATCAGGAGAATATCTCTGGAAAATACATACAAAC
TGTTTATTCAACTTCTGATAGGTCTGTCATTGAAAGAGATATGTGCACTTACTGCCGAAAACCCTTGGGTGTAGAAACTAAAATGATTTT
AGATGAATTACAAATTTGCTGCCATTCTACTTGCTTTAAGTGTGAAATATGCAAGCAGCCTTTGGAAAATCTACAAGCGGGTGATAGTAT
TTGGATTTATAGACAGACAATACACTGTGAACCTTGCTACTCTAAAATTATGGCAAAGTGGATTCCATAACTCTGGCACAAGGAAATCAA
GATGAAAAGCACTCATTAAGGAATTAAAGTTACAAGTTTTATCTTAATAATATGTAATCTAGAAAAGCTTTCACATTGAAGATCAACTCT
TGTACAAAATTAACAATTCTGTTATTGCATAAGTAATCTAATTGTCTTCAATAAGGTCACACACATAAAAAGAGCCATCTGGTCTCTGGC
TAGAGTTAGCAATAAAAAGTTCAAATGGTTCCAGATTCCAGTGTCAAAGGAGTGATGCATTACACTCCAGCCAGGTCCATCCCTGCTCCG
TATGTTGGCTGTGAGTGGTGGTTTCCATTTAAACCAAGTTTCTCATTTCTTCACCTTTTTTTCTCTAAGAATTTGGATTCGTAGACATTG
ACATCCCGAAGAACTGTCAAGGAAGCAAGATATGCTTTCTTCATCTGCAAAAGAAATACTAACAACAATTTTCTTATACAGTTTGGCAGA
AAGATGTTAACATAAAAAGTTTATATACCTCAAAAATCACTAAACTTTCCAGATCTCTGTCCTATTATTTGTAACACAAGGGGCATTGGA
TAAAATGATTTCTAGGGTTCCTTTTGCTTCCCAAATTCTCTGATTCTAAAGCAGTTTTTAGAATCATTAGCTCTTTGGAAACATATATGC
ATACATGTTTGTTAAGCCTATTGAACTAGGTAGGACATATAAACAATTTAATTTTAGTGTCATTGTTTAATCACAGACTTAGTGTTTGAA
AACTGTGTTTTAAAAACAGAAACAGATTGATGGGTAACAGGTAAAATATGACATGTATAGCTTACATGTTATTATTTGTTAAATTTTCTT
TGTATACATTTCAAAATCTGGGTATACTTATAATCCATTAGAAGTAATGGTTATGGACTAAAAAGATATGTTCTTTAGTATGTTATATAT

>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000377246_chr13_78202082_+_3489nt
GGGGGCGGCAGCGGTGGTAGCAGCTGGTACCTCCCGCCGCCTCTGTTCGGAGGGTCGCGGGGCACCGAGGTGCTTTCCGGCCGCCCTCTG
GTCGGCCACCCAAAGCCGCGGGCGCTGATGATGGGTGAGGAGGGGGCGGCAAGATTTCGGGCGCCCCTGCCCTGAACGCCCTCAGCTGCT
GCCGCCGGGGCCGCTCCAGTGCCTGCGAACTCTGAGGAGCCGAGGCGCCGGTGAGAGCAAGGACGCTGCAAACTTGCGCAGCGCGGGGGC
TGGGATTCACGCCCAGAAGTTCAGCAGGCAGACAGTCCGAAGCCTTCCCGCAGCGGAGAGATAGCTTGAGGGTGCGCAAGACGGCAGCCT
CCGCCCTCGGTTCCCGCCCAGACCGGGCAGAAGAGCTTGGAGGAGCCAAAAGGAACGCAAAAGGCGGCCAGGACAGCGTGCAGCAGCTGG
GAGCCGCCGTTCTCAGCCTTAAAAGTTGCAGAGATTGGAGGCTGCCCCGAGAGGGGACAGACCCCAGCTCCGACTGCGGGGGGCAGGAGA
GGACGGTACCCAACTGCCACCTCCCTTCAACCATAGTAGTTCCTCTGTACCGAGCGCAGCGAGCTACAGACGGGGGCGCGGCACTCGGCG
CGGAGAGCGGGAGGCTCAAGGTCCCAGCCAGTGAGCCCAGTGTGCTTGAGTGTCTCTGGACTCGCCCCTGAGCTTCCAGGTCTGTTTCAT
TTAGACTCCTGCTCGCCTCCGTGCAGTTGGGGGAAAGCAAGAGACTTGCGCGCACGCACAGTCCTCTGGAGATCAGGTGGAAGGAGCCGC
TGGGTACCAAGGACTGTTCAGAGCCTCTTCCCATCTCGGGGAGAGCGAAGGGTGAGGCTGGGCCCGGAGAGCAGTGTAAACGGCCTCCTC
CGGCGGGATGGGAGCCATCGGGCTCCTGTGGCTCCTGCCGCTGCTGCTTTCCACGGCAGCTGTGGGCTCCGGGATGGGGACCGGCCAGCG
CGCGGGCTCCCCAGCTGCGGGGCCGCCGCTGCAGCCCCGGGAGCCACTCAGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCAGTTGACTT
CGTGGTGCCCTCGCTCTTCCGTGTCTACGCCCGGGACCTACTGCTGCCACCATCCTCCTCGGAGCTGAAGGCTGGCAGGCCCGAGGCCCG
CGGCTCGCTAGCTCTGGACTGCGCCCCGCTGCTCAGGTTGCTGGGGCCGGCGCCGGGGGTCTCCTGGACCGCCGGTTCACCAGCCCCGGC
AGAGGCCCGGACGCTGTCCAGGGTGCTGAAGGGCGGCTCCGTGCGCAAGCTCCGGCGTGCCAAGCAGTTGGTGCTGGAGCTGGGCGAGGA
GGCGATCTTGGAGGGTTGCGTCGGGCCCCCCGGGGAGGCGGCTGTGGGGCTGCTCCAGTTCAATCTCAGCGAGCTGTTCAGTTGGTGGAT
TCGCCAAGGCGAAGGGCGACTGAGGATCCGCCTGATGCCCGAGAAGAAGGCGTCGGAAGTGGGCAGAGAGGGAAGGCTGTCCGCGGCAAT
TCGCGCCTCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACTGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCC
TGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTT
TGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGC
CTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGA
CTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTC
TGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGAGACCAGAA
CCTGGAAAATTTAATTGAAGTAAATTCTCATGTGTCTGAAAACAAGAATGGAAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGA
TACTGTTGTGTACACAAGGACATATGTGGAGAATAGTAAATCACCCAAGGATGGATATCAGGAGAATATCTCTGGAAAATACATACAAAC
TGTTTATTCAACTTCTGATAGGTCTGTCATTGAAAGAGATATGTGCACTTACTGCCGAAAACCCTTGGGTGTAGAAACTAAAATGATTTT
AGATGAATTACAAATTTGCTGCCATTCTACTTGCTTTAAGTGTGAAATATGCAAGCAGCCTTTGGAAAATCTACAAGCGGGTGATAGTAT
TTGGATTTATAGACAGACAATACACTGTGAACCTTGCTACTCTAAAATTATGGCAAAGTGGATTCCATAACTCTGGCACAAGGAAATCAA
GATGAAAAGCACTCATTAAGGAATTAAAGTTACAAGTTTTATCTTAATAATATGTAATCTAGAAAAGCTTTCACATTGAAGATCAACTCT
TGTACAAAATTAACAATTCTGTTATTGCATAAGTAATCTAATTGTCTTCAATAAGGTCACACACATAAAAAGAGCCATCTGGTCTCTGGC
TAGAGTTAGCAATAAAAAGTTCAAATGGTTCCAGATTCCAGTGTCAAAGGAGTGATGCATTACACTCCAGCCAGGTCCATCCCTGCTCCG
TATGTTGGCTGTGAGTGGTGGTTTCCATTTAAACCAAGTTTCTCATTTCTTCACCTTTTTTTCTCTAAGAATTTGGATTCGTAGACATTG
ACATCCCGAAGAACTGTCAAGGAAGCAAGATATGCTTTCTTCATCTGCAAAAGAAATACTAACAACAATTTTCTTATACAGTTTGGCAGA
AAGATGTTAACATAAAAAGTTTATATACCTCAAAAATCACTAAACTTTCCAGATCTCTGTCCTATTATTTGTAACACAAGGGGCATTGGA
TAAAATGATTTCTAGGGTTCCTTTTGCTTCCCAAATTCTCTGATTCTAAAGCAGTTTTTAGAATCATTAGCTCTTTGGAAACATATATGC
ATACATGTTTGTTAAGCCTATTGAACTAGGTAGGACATATAAACAATTTAATTTTAGTGTCATTGTTTAATCACAGACTTAGTGTTTGAA
AACTGTGTTTTAAAAACAGAAACAGATTGATGGGTAACAGGTAAAATATGACATGTATAGCTTACATGTTATTATTTGTTAAATTTTCTT
TGTATACATTTCAAAATCTGGGTATACTTATAATCCATTAGAAGTAATGGTTATGGACTAAAAAGATATGTTCTTTAGTATGTTATATAT

>In-frame_ALK_ENST00000389048_chr2_29754781_-_SCEL_ENST00000349847_chr13_78202082_+_2735nt
GGGGGCGGCAGCGGTGGTAGCAGCTGGTACCTCCCGCCGCCTCTGTTCGGAGGGTCGCGGGGCACCGAGGTGCTTTCCGGCCGCCCTCTG
GTCGGCCACCCAAAGCCGCGGGCGCTGATGATGGGTGAGGAGGGGGCGGCAAGATTTCGGGCGCCCCTGCCCTGAACGCCCTCAGCTGCT
GCCGCCGGGGCCGCTCCAGTGCCTGCGAACTCTGAGGAGCCGAGGCGCCGGTGAGAGCAAGGACGCTGCAAACTTGCGCAGCGCGGGGGC
TGGGATTCACGCCCAGAAGTTCAGCAGGCAGACAGTCCGAAGCCTTCCCGCAGCGGAGAGATAGCTTGAGGGTGCGCAAGACGGCAGCCT
CCGCCCTCGGTTCCCGCCCAGACCGGGCAGAAGAGCTTGGAGGAGCCAAAAGGAACGCAAAAGGCGGCCAGGACAGCGTGCAGCAGCTGG
GAGCCGCCGTTCTCAGCCTTAAAAGTTGCAGAGATTGGAGGCTGCCCCGAGAGGGGACAGACCCCAGCTCCGACTGCGGGGGGCAGGAGA
GGACGGTACCCAACTGCCACCTCCCTTCAACCATAGTAGTTCCTCTGTACCGAGCGCAGCGAGCTACAGACGGGGGCGCGGCACTCGGCG
CGGAGAGCGGGAGGCTCAAGGTCCCAGCCAGTGAGCCCAGTGTGCTTGAGTGTCTCTGGACTCGCCCCTGAGCTTCCAGGTCTGTTTCAT
TTAGACTCCTGCTCGCCTCCGTGCAGTTGGGGGAAAGCAAGAGACTTGCGCGCACGCACAGTCCTCTGGAGATCAGGTGGAAGGAGCCGC
TGGGTACCAAGGACTGTTCAGAGCCTCTTCCCATCTCGGGGAGAGCGAAGGGTGAGGCTGGGCCCGGAGAGCAGTGTAAACGGCCTCCTC
CGGCGGGATGGGAGCCATCGGGCTCCTGTGGCTCCTGCCGCTGCTGCTTTCCACGGCAGCTGTGGGCTCCGGGATGGGGACCGGCCAGCG
CGCGGGCTCCCCAGCTGCGGGGCCGCCGCTGCAGCCCCGGGAGCCACTCAGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCAGTTGACTT
CGTGGTGCCCTCGCTCTTCCGTGTCTACGCCCGGGACCTACTGCTGCCACCATCCTCCTCGGAGCTGAAGGCTGGCAGGCCCGAGGCCCG
CGGCTCGCTAGCTCTGGACTGCGCCCCGCTGCTCAGGTTGCTGGGGCCGGCGCCGGGGGTCTCCTGGACCGCCGGTTCACCAGCCCCGGC
AGAGGCCCGGACGCTGTCCAGGGTGCTGAAGGGCGGCTCCGTGCGCAAGCTCCGGCGTGCCAAGCAGTTGGTGCTGGAGCTGGGCGAGGA
GGCGATCTTGGAGGGTTGCGTCGGGCCCCCCGGGGAGGCGGCTGTGGGGCTGCTCCAGTTCAATCTCAGCGAGCTGTTCAGTTGGTGGAT
TCGCCAAGGCGAAGGGCGACTGAGGATCCGCCTGATGCCCGAGAAGAAGGCGTCGGAAGTGGGCAGAGAGGGAAGGCTGTCCGCGGCAAT
TCGCGCCTCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACTGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCC
TGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTT
TGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGC
CTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGA
CTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTC
TGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGAGACCAGAA
CCTGGAAAATTTAATTGAAGTAAATTCTCATGTGTCTGAAAACAAGAATGGAAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGA
TACTGTTGTGTACACAAGGACATATGTGGAGAATAGTAAATCACCCAAGGATGGATATCAGGAGAATATCTCTGGAAAATACATACAAAC
TGTTTATTCAACTTCTGATAGGTCTGTCATTGAAAGAGATATGTGCACTTACTGCCGAAAACCCTTGGGTGTAGAAACTAAAATGATTTT
AGATGAATTACAAATTTGCTGCCATTCTACTTGCTTTAAGTGTGAAATATGCAAGCAGCCTTTGGAAAATCTACAAGCGGGTGATAGTAT
TTGGATTTATAGACAGACAATACACTGTGAACCTTGCTACTCTAAAATTATGGCAAAGTGGATTCCATAACTCTGGCACAAGGAAATCAA
GATGAAAAGCACTCATTAAGGAATTAAAGTTACAAGTTTTATCTTAATAATATGTAATCTAGAAAAGCTTTCACATTGAAGATCAACTCT
TGTACAAAATTAACAATTCTGTTATTGCATAAGTAATCTAATTGTCTTCAATAAGGTCACACACATAAAAAGAGCCATCTGGTCTCTGGC


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FusionGenePPI for ALK_SCEL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALKPTN, SHC1, PLCG1, JAK3, SHC3, RAB35, HSPD1, MAP3K4, GRB2, SOCS1, PIK3CB, RAD17, IRF7, EPHB2, EIF4B, MAPK8IP3, CENPF, PLCB2, PDX1, STAT3, MAP2K7, JAK2, MAP3K5, MEP1B, GAK, EPHA1, UBASH3A, MTIF2, MYLK, MAP3K1, MAPK1, SOCS5, CDK13, SMC6, IRS4, KRT18, KRT74, IRS1, IKBKG, ZC3HC1, TNK2, ERRFI1, PIK3R1, HSP90AA1, BCAR1, ACTB, PDLIM3, VIM, TUBB4B, MYO6, MYH10, MYH9, TUBGCP2, ACTN4, CORO1C, FLII, BICD2, GNB2L1, SRC, PXN, PRKCQ, MYBPC2, CDK9, PPM1A, DUSP19SCELTXNIP, APP, GOLGA2, KIFC3, NMI, FXR2, MTUS2, TSGA10, TSC22D2, CDH1, FRMD1, RAB11B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ALK_SCEL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALKQ9UM73DB08865CrizotinibALK tyrosine kinase receptorsmall moleculeapproved
HgeneALKQ9UM73DB09063CeritinibALK tyrosine kinase receptorsmall moleculeapproved

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RelatedDiseases for ALK_SCEL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALKC0007131Non-Small Cell Lung Carcinoma28CTD_human
HgeneALKC0027819Neuroblastoma12CTD_human;ORPHANET
HgeneALKC0152013Adenocarcinoma of lung (disorder)8CTD_human
HgeneALKC0206180Ki-1+ Anaplastic Large Cell Lymphoma6CTD_human
HgeneALKC2751681NEUROBLASTOMA, SUSCEPTIBILITY TO, 34UNIPROT
HgeneALKC0018199Granuloma, Plasma Cell3CTD_human
HgeneALKC0007621Neoplastic Cell Transformation2CTD_human
HgeneALKC0027627Neoplasm Metastasis2CTD_human
HgeneALKC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneALKC0006118Brain Neoplasms1CTD_human
HgeneALKC0007134Renal Cell Carcinoma1CTD_human
HgeneALKC0011570Mental Depression1PSYGENET
HgeneALKC0011581Depressive disorder1PSYGENET
HgeneALKC0027643Neoplasm Recurrence, Local1CTD_human
HgeneALKC0036341Schizophrenia1PSYGENET
HgeneALKC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneALKC0085269Plasma Cell Granuloma, Pulmonary1CTD_human
HgeneALKC0278601Inflammatory Breast Carcinoma1CTD_human