FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15614

FusionGeneSummary for GTF2E2_GSR

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF2E2_GSR
Fusion gene ID: 15614
HgeneTgene
Gene symbol

GTF2E2

GSR

Gene ID

2961

2936

Gene namegeneral transcription factor IIE subunit 2glutathione-disulfide reductase
SynonymsFE|TF2E2|TFIIE-B|TTD6GR|HEL-75|HEL-S-122m
Cytomap

8p12

8p12

Type of geneprotein-codingprotein-coding
Descriptiontranscription initiation factor IIE subunit betaTFIIE beta subunitTFIIE-betageneral transcription factor IIE, polypeptide 2, beta 34kDaglutathione reductase, mitochondrialGRaseepididymis luminal protein 75epididymis secretory sperm binding protein Li 122mglutathione S-reductase
Modification date2018052320180523
UniProtAcc

P29084

P00390

Ensembl transtripts involved in fusion geneENST00000355904, ENST00000522833, 
ENST00000221130, ENST00000414019, 
ENST00000546342, ENST00000537535, 
ENST00000541648, 
Fusion gene scores* DoF score10 X 5 X 5=2502 X 2 X 2=8
# samples 102
** MAII scorelog2(10/250*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: GTF2E2 [Title/Abstract] AND GSR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-50-6592-01AGTF2E2chr8

30510950

-GSRchr8

30550572

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355904ENST00000221130GTF2E2chr8

30510950

-GSRchr8

30550572

-
Frame-shiftENST00000355904ENST00000414019GTF2E2chr8

30510950

-GSRchr8

30550572

-
5CDS-intronENST00000355904ENST00000546342GTF2E2chr8

30510950

-GSRchr8

30550572

-
5CDS-intronENST00000355904ENST00000537535GTF2E2chr8

30510950

-GSRchr8

30550572

-
5CDS-intronENST00000355904ENST00000541648GTF2E2chr8

30510950

-GSRchr8

30550572

-
intron-3CDSENST00000522833ENST00000221130GTF2E2chr8

30510950

-GSRchr8

30550572

-
intron-3CDSENST00000522833ENST00000414019GTF2E2chr8

30510950

-GSRchr8

30550572

-
intron-intronENST00000522833ENST00000546342GTF2E2chr8

30510950

-GSRchr8

30550572

-
intron-intronENST00000522833ENST00000537535GTF2E2chr8

30510950

-GSRchr8

30550572

-
intron-intronENST00000522833ENST00000541648GTF2E2chr8

30510950

-GSRchr8

30550572

-

Top

FusionProtFeatures for GTF2E2_GSR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GTF2E2

P29084

GSR

P00390

Recruits TFIIH to the initiation complex and stimulatesthe RNA polymerase II C-terminal domain kinase and DNA-dependentATPase activities of TFIIH. Both TFIIH and TFIIE are required forpromoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398,ECO:0000269|PubMed:1956404}. Maintains high levels of reduced glutathione in thecytosol.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GTF2E2_GSR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GTF2E2_GSR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GTF2E2GTF2B, GTF2E1, POLR2A, GTF2A1, SND1, ERCC3, FOS, JUN, GTF2F1, TBP, GTF2E2, XPA, GTF2F2, TPR, HNRNPA1, MTA2, HSP90AB1, EXOC4, DNM2, UBR5, ATF7IP, APP, CDK7, MMS19, MCC, PBDC1, SEC24D, SHMT2, MOV10, NXF1, EEF1G, SART3, SIN3A, KLF5, MDM2, EIF2A, SBDS, OIP5, UBLCP1, FAM49B, MIS18A, DNAJC2, PHPT1, SLK, NARS, TPP2, HDGFRP2, PDCD10, HDLBP, NAA15, VRK1, TOMM34, UBE2T, HIBCH, ACTBL2, RBM12, LYPLA1, FARSB, MCTS1, STX7, FEN1, BLVRB, AK4, DUSP3, PTPN11, LRRC40, EEF1A2, ETF1, MDC1, IBA57, HMGN5, RPRD1A, PPP1R8, ZMPSTE24, TSFM, TLN1, PMVK, SLC9A3R2, UGP2, GINS4, TACC3, GINS1, EIF3J, WDHD1, CMTR1, WIBG, GINS3, CSTF3, ACAA1, EFHD2, ADSL, MESDC2, SNX5, SF3A1, GMPS, ZRANB2, UBA6, CHORDC1, DIS3, PPME1, SPRYD4, TOP1, YARS, PACSIN2, EIF5B, CSTF1, CAB39, SRRT, DBNL, RNF20, C21orf33, TRIM25GSRPJA1, GSR, ELAVL1, ISG15, FOLR1, C11orf49, ADSS, CNDP2, DDX39A, EEF2, GBP2, GINS2, AHSA1, DDX39B, LDHA, NDRG1, PROSC, HSPD1, KYNU, MVD, NAMPT, PEPD, RPS6KA1, AIFM1, ASS1, FDXR, PIR, LSM12, TOMM40, NTRK1, MCM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GTF2E2_GSR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSRP00390DB00262CarmustineGlutathione reductase, mitochondrialsmall moleculeapproved|investigational
TgeneGSRP00390DB00143GlutathioneGlutathione reductase, mitochondrialsmall moleculeapproved|investigational|nutraceutical

Top

RelatedDiseases for GTF2E2_GSR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSRC0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneGSRC0002871Anemia1CTD_human
TgeneGSRC0002878Anemia, Hemolytic1CTD_human
TgeneGSRC0011616Contact Dermatitis1CTD_human
TgeneGSRC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneGSRC0013604Edema1CTD_human
TgeneGSRC0020550Hyperthyroidism1CTD_human
TgeneGSRC0020615Hypoglycemia1CTD_human
TgeneGSRC0033626Protein Deficiency1CTD_human
TgeneGSRC0242422Parkinsonian Disorders1CTD_human
TgeneGSRC0524851Neurodegenerative Disorders1CTD_human
TgeneGSRC1456865Ureteral Calculi1CTD_human
TgeneGSRC4277682Chemical and Drug Induced Liver Injury1CTD_human