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Fusion gene ID: 15612 |
FusionGeneSummary for GTF2E2_FBXO16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GTF2E2_FBXO16 | Fusion gene ID: 15612 | Hgene | Tgene | Gene symbol | GTF2E2 | FBXO16 | Gene ID | 2961 | 157574 |
| Gene name | general transcription factor IIE subunit 2 | F-box protein 16 | |
| Synonyms | FE|TF2E2|TFIIE-B|TTD6 | FBX16 | |
| Cytomap | 8p12 | 8p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription initiation factor IIE subunit betaTFIIE beta subunitTFIIE-betageneral transcription factor IIE, polypeptide 2, beta 34kDa | F-box only protein 16 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P29084 | Q8IX29 | |
| Ensembl transtripts involved in fusion gene | ENST00000355904, ENST00000522833, | ENST00000380254, ENST00000346498, ENST00000518734, ENST00000517436, ENST00000519471, | |
| Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/250*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: GTF2E2 [Title/Abstract] AND FBXO16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-VP-A87D-01A | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355904 | ENST00000380254 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| Frame-shift | ENST00000355904 | ENST00000346498 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| In-frame | ENST00000355904 | ENST00000518734 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| 5CDS-intron | ENST00000355904 | ENST00000517436 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| 5CDS-intron | ENST00000355904 | ENST00000519471 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| intron-3CDS | ENST00000522833 | ENST00000380254 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| intron-3CDS | ENST00000522833 | ENST00000346498 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| intron-3CDS | ENST00000522833 | ENST00000518734 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| intron-intron | ENST00000522833 | ENST00000517436 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
| intron-intron | ENST00000522833 | ENST00000519471 | GTF2E2 | chr8 | 30492549 | - | FBXO16 | chr8 | 28286253 | - |
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FusionProtFeatures for GTF2E2_FBXO16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GTF2E2 | FBXO16 |
| Recruits TFIIH to the initiation complex and stimulatesthe RNA polymerase II C-terminal domain kinase and DNA-dependentATPase activities of TFIIH. Both TFIIH and TFIIE are required forpromoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398,ECO:0000269|PubMed:1956404}. | Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GTF2E2 | chr8:30492549 | chr8:28286253 | ENST00000355904 | - | 3 | 8 | 26_36 | 86 | 292 | Compositional bias | Note=Poly-Ser |
| Hgene | GTF2E2 | chr8:30492549 | chr8:28286253 | ENST00000355904 | - | 3 | 8 | 37_42 | 86 | 292 | Compositional bias | Note=Lys-rich (basic) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GTF2E2 | chr8:30492549 | chr8:28286253 | ENST00000355904 | - | 3 | 8 | 251_271 | 86 | 292 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Hgene | >GTF2E2 | chr8:30492549 | chr8:28286253 | ENST00000355904 | - | 3 | 8 | 66_146 | 86 | 292 | DNA binding | TFIIE beta |
| Tgene | FBXO16 | chr8:30492549 | chr8:28286253 | ENST00000380254 | - | 7 | 9 | 86_132 | 289 | 293 | Domain | F-box |
| Tgene | FBXO16 | chr8:30492549 | chr8:28286253 | ENST00000518734 | - | 6 | 8 | 86_132 | 277 | 281 | Domain | F-box |
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FusionGeneSequence for GTF2E2_FBXO16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GTF2E2_ENST00000355904_chr8_30492549_-_FBXO16_ENST00000380254_chr8_28286253_-_89aa >In-frame_GTF2E2_ENST00000355904_chr8_30492549_-_FBXO16_ENST00000518734_chr8_28286253_-_89aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GTF2E2_ENST00000355904_chr8_30492549_-_FBXO16_ENST00000380254_chr8_28286253_-_268nt ATGGATCCAAGCCTGTTGAGAGAAAGGGAGCTGTTCAAAAAACGAGCTCTTTCTACTCCTGTAGTAGAAAAACGTTCAGCATCTTCTGAG TCATCATCATCATCGTCAAAGAAGAAGAAAACAAAGGTAGAACATGGAGGATCGTCAGGCTCTAAACAAAATTCTGATCATAGCAATGGA >In-frame_GTF2E2_ENST00000355904_chr8_30492549_-_FBXO16_ENST00000518734_chr8_28286253_-_268nt ATGGATCCAAGCCTGTTGAGAGAAAGGGAGCTGTTCAAAAAACGAGCTCTTTCTACTCCTGTAGTAGAAAAACGTTCAGCATCTTCTGAG TCATCATCATCATCGTCAAAGAAGAAGAAAACAAAGGTAGAACATGGAGGATCGTCAGGCTCTAAACAAAATTCTGATCATAGCAATGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GTF2E2_ENST00000355904_chr8_30492549_-_FBXO16_ENST00000380254_chr8_28286253_-_866nt GCGGTGGCTGCCGGGACTGAGCTCCTAGCACCCGATCGGGAAGTGGCGGGCGGAGTCCCGGGTCCAGTCGCCGCCTCAGCTACCGCCGCT GCCGCCGCCGCCGCCGCCACCGCCAGTGGTGAGACCCCGACCTGGCGGGTCAGCGCTGGGCGTGCGTGCGGGCAGGCGGGGGCGCTGACG AGAAGCAGGAAGAGGGTGCAGTGCCGGCGTGGGCGGCCGGCCGAGGCGGAGGCGCAGGAAGGGGGCGGCGAGTCGTGCGAGGCTGCCCTT CTCACTCAGCATTATGGATCCAAGCCTGTTGAGAGAAAGGGAGCTGTTCAAAAAACGAGCTCTTTCTACTCCTGTAGTAGAAAAACGTTC AGCATCTTCTGAGTCATCATCATCATCGTCAAAGAAGAAGAAAACAAAGGTAGAACATGGAGGATCGTCAGGCTCTAAACAAAATTCTGA TCATAGCAATGGATCATTTAACTTGAAAGCTTTGTCAGGAAGCTCTGGATATAAGTTTGGTGTTCTTGCTAAGATTGTGAATTACATGAA GATGTCCCTAAGTGCCAGCTCTCCCCTAAAAGTTCCAGCTCATCTCGCCTGGCCTCCCCCTGAGTCAGTGGGACTCCCAGACACTGCCAC CACAGCTGAAATTCTCATGCAGCATCCTCACAGGCACCCTGGGCCCCAAGCATGACTCATCCAGGTTCCAGAGCCAAAGTGGACTGAACA TGGAAAGACTTTTATTATAGAAATGACAAGATGCTTTGCACAGTGGAGAGCTGAATTTACTTGGCTCCCATTAGAAACTCTTTCAGCTTA >In-frame_GTF2E2_ENST00000355904_chr8_30492549_-_FBXO16_ENST00000518734_chr8_28286253_-_635nt GCGGTGGCTGCCGGGACTGAGCTCCTAGCACCCGATCGGGAAGTGGCGGGCGGAGTCCCGGGTCCAGTCGCCGCCTCAGCTACCGCCGCT GCCGCCGCCGCCGCCGCCACCGCCAGTGGTGAGACCCCGACCTGGCGGGTCAGCGCTGGGCGTGCGTGCGGGCAGGCGGGGGCGCTGACG AGAAGCAGGAAGAGGGTGCAGTGCCGGCGTGGGCGGCCGGCCGAGGCGGAGGCGCAGGAAGGGGGCGGCGAGTCGTGCGAGGCTGCCCTT CTCACTCAGCATTATGGATCCAAGCCTGTTGAGAGAAAGGGAGCTGTTCAAAAAACGAGCTCTTTCTACTCCTGTAGTAGAAAAACGTTC AGCATCTTCTGAGTCATCATCATCATCGTCAAAGAAGAAGAAAACAAAGGTAGAACATGGAGGATCGTCAGGCTCTAAACAAAATTCTGA TCATAGCAATGGATCATTTAACTTGAAAGCTTTGTCAGGAAGCTCTGGATATAAGTTTGGTGTTCTTGCTAAGATTGTGAATTACATGAA GATGTCCCTAAGTGCCAGCTCTCCCCTAAAAGTTCCAGCTCATCTCGCCTGGCCTCCCCCTGAGTCAGTGGGACTCCCAGACACTGCCAC |
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FusionGenePPI for GTF2E2_FBXO16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GTF2E2 | GTF2B, GTF2E1, POLR2A, GTF2A1, SND1, ERCC3, FOS, JUN, GTF2F1, TBP, GTF2E2, XPA, GTF2F2, TPR, HNRNPA1, MTA2, HSP90AB1, EXOC4, DNM2, UBR5, ATF7IP, APP, CDK7, MMS19, MCC, PBDC1, SEC24D, SHMT2, MOV10, NXF1, EEF1G, SART3, SIN3A, KLF5, MDM2, EIF2A, SBDS, OIP5, UBLCP1, FAM49B, MIS18A, DNAJC2, PHPT1, SLK, NARS, TPP2, HDGFRP2, PDCD10, HDLBP, NAA15, VRK1, TOMM34, UBE2T, HIBCH, ACTBL2, RBM12, LYPLA1, FARSB, MCTS1, STX7, FEN1, BLVRB, AK4, DUSP3, PTPN11, LRRC40, EEF1A2, ETF1, MDC1, IBA57, HMGN5, RPRD1A, PPP1R8, ZMPSTE24, TSFM, TLN1, PMVK, SLC9A3R2, UGP2, GINS4, TACC3, GINS1, EIF3J, WDHD1, CMTR1, WIBG, GINS3, CSTF3, ACAA1, EFHD2, ADSL, MESDC2, SNX5, SF3A1, GMPS, ZRANB2, UBA6, CHORDC1, DIS3, PPME1, SPRYD4, TOP1, YARS, PACSIN2, EIF5B, CSTF1, CAB39, SRRT, DBNL, RNF20, C21orf33, TRIM25 | FBXO16 | CETN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GTF2E2_FBXO16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GTF2E2_FBXO16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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