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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15607

FusionGeneSummary for GTF2B_BPI

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF2B_BPI
Fusion gene ID: 15607
HgeneTgene
Gene symbol

GTF2B

BPI

Gene ID

2959

671

Gene namegeneral transcription factor IIBbactericidal permeability increasing protein
SynonymsTF2B|TFIIBBPIFD1|rBPI
Cytomap

1p22.2

20q11.23

Type of geneprotein-codingprotein-coding
Descriptiontranscription initiation factor IIBRNA polymerase II transcription factor IIBS300-IIgeneral transcription factor TFIIBbactericidal permeability-increasing proteinBPI fold containing family D, member 1CAP 57recombinant BPI holoprotein, rBPI
Modification date2018052320180409
UniProtAcc

Q00403

P17213

Ensembl transtripts involved in fusion geneENST00000370500, ENST00000494819, 
ENST00000262865, ENST00000489102, 
ENST00000451435, 
Fusion gene scores* DoF score3 X 2 X 2=125 X 6 X 6=180
# samples 36
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GTF2B [Title/Abstract] AND BPI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGTF2B

GO:0006367

transcription initiation from RNA polymerase II promoter

3029109

HgeneGTF2B

GO:0006473

protein acetylation

12931194

HgeneGTF2B

GO:0043923

positive regulation by host of viral transcription

24441171

HgeneGTF2B

GO:0051123

RNA polymerase II transcriptional preinitiation complex assembly

3029109|9841876

HgeneGTF2B

GO:1904798

positive regulation of core promoter binding

9841876

TgeneBPI

GO:0032715

negative regulation of interleukin-6 production

8409400

TgeneBPI

GO:0032717

negative regulation of interleukin-8 production

8409400

TgeneBPI

GO:0032720

negative regulation of tumor necrosis factor production

8409400

TgeneBPI

GO:0043031

negative regulation of macrophage activation

8409400


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A254-01AGTF2Bchr1

89357166

-BPIchr20

36959450

+
TCGALDBRCATCGA-AR-A254-01AGTF2Bchr1

89357166

-BPIchr20

36962832

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370500ENST00000262865GTF2Bchr1

89357166

-BPIchr20

36959450

+
5CDS-3UTRENST00000370500ENST00000489102GTF2Bchr1

89357166

-BPIchr20

36959450

+
5CDS-intronENST00000370500ENST00000451435GTF2Bchr1

89357166

-BPIchr20

36959450

+
5UTR-3CDSENST00000494819ENST00000262865GTF2Bchr1

89357166

-BPIchr20

36959450

+
5UTR-3UTRENST00000494819ENST00000489102GTF2Bchr1

89357166

-BPIchr20

36959450

+
5UTR-intronENST00000494819ENST00000451435GTF2Bchr1

89357166

-BPIchr20

36959450

+
In-frameENST00000370500ENST00000262865GTF2Bchr1

89357166

-BPIchr20

36962832

+
5CDS-3UTRENST00000370500ENST00000489102GTF2Bchr1

89357166

-BPIchr20

36962832

+
5CDS-intronENST00000370500ENST00000451435GTF2Bchr1

89357166

-BPIchr20

36962832

+
5UTR-3CDSENST00000494819ENST00000262865GTF2Bchr1

89357166

-BPIchr20

36962832

+
5UTR-3UTRENST00000494819ENST00000489102GTF2Bchr1

89357166

-BPIchr20

36962832

+
5UTR-intronENST00000494819ENST00000451435GTF2Bchr1

89357166

-BPIchr20

36962832

+

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FusionProtFeatures for GTF2B_BPI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GTF2B

Q00403

BPI

P17213

General factor that plays a major role in the activationof eukaryotic genes transcribed by RNA polymerase II.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBPIchr1:89357166chr20:36962832ENST00000262865+1115468_487428488RegionCentral sheet%2C part 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGTF2Bchr1:89357166chr20:36962832ENST00000370500-17124_2005317RepeatNote=1
HgeneGTF2Bchr1:89357166chr20:36962832ENST00000370500-17218_2945317RepeatNote=2
HgeneGTF2Bchr1:89357166chr20:36962832ENST00000370500-1711_425317Zinc fingerTFIIB-type
TgeneBPIchr1:89357166chr20:36962832ENST00000262865+1115226_290428488RegionCentral sheet%2C part 2
TgeneBPIchr1:89357166chr20:36962832ENST00000262865+1115240_245428488RegionCleavage sites for elastase
TgeneBPIchr1:89357166chr20:36962832ENST00000262865+1115291_461428488RegionC-terminal barrel
TgeneBPIchr1:89357166chr20:36962832ENST00000262865+111532_42428488RegionCentral sheet%2C part 1
TgeneBPIchr1:89357166chr20:36962832ENST00000262865+111541_224428488RegionN-terminal barrel


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FusionGeneSequence for GTF2B_BPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GTF2B_ENST00000370500_chr1_89357166_-_BPI_ENST00000262865_chr20_36962832_+_65aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GTF2B_ENST00000370500_chr1_89357166_-_BPI_ENST00000262865_chr20_36962832_+_197nt
ATGGCGTCTACCAGCCGGTTGAATTGCTGCAGGATATCATGAACTACATTGTACCCATTCTTGTGCTGCCCAGGGTTAACGAGAAACTAC
AGAAAGGCTTCCCTCTCCCGACGCCGGCCAGAGTCCAGCTCTACAACGTAGTGCTTCAGCCTCACCAGAACTTCCTGCTGTTCGGTGCAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GTF2B_ENST00000370500_chr1_89357166_-_BPI_ENST00000262865_chr20_36962832_+_637nt
ACGACTGCGTGGGTGAGTCGTCTATAAAAACTCATCTCTGCGCGTCTCTTCGCCACATTCGCTTCCTGCTTTCGGTGTGTCTGTTGTGTC
TTGTTGCGGGCACCGCAGTCGCCGTGAAGATGGCGTCTACCAGCCGGTTGAATTGCTGCAGGATATCATGAACTACATTGTACCCATTCT
TGTGCTGCCCAGGGTTAACGAGAAACTACAGAAAGGCTTCCCTCTCCCGACGCCGGCCAGAGTCCAGCTCTACAACGTAGTGCTTCAGCC
TCACCAGAACTTCCTGCTGTTCGGTGCAGACGTTGTCTATAAATGAAGGCACCAGGGGTGCCGGGGGCTGTCAGCCACACCTGTTCCTGA
TGGGCTGTGGGGCACCGGCTGCCTTTCCCCAGGGAATCCTCTCCAGATCTTAACCAAGAGCCCCTTGCAAACTTCTTCGACTCAGATTCA
GAAATGATCTAAACACGAGGAAACATTATTCATTGGAAAAGTGCATGGTGTGTATTTTAGGGATTATGAGCTTCTTTCAAGGGCTAAGGC
TGCAGAGATATTTCCTCCAGGAATCGTGTTTCAATTGTAACCAAGAAATTTCCATTTGTGCTTCATGAAAAAAAACTTCTGGTTTTTTTC


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FusionGenePPI for GTF2B_BPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GTF2BNCOA4, POLR2A, GTF2E1, GTF2F1, TBP, CTBP1, IKZF1, TAF11, GTF2H4, GTF2E2, CREBBP, JUN, GTF2F2, NCOA1, REL, HSF1, BCL3, TBPL1, MED21, ATF4, POLR3A, PKP2, TCEA1, RELA, NR5A1, DHX9, FOXF2, KLF5, NR2F1, PSMC2, MECP2, POLR2J, CTDP1, POLR2H, MKX, SAP25, REST, TAF9, NCOR1, NR1D2, ESR1, PSMA3, POU3F2, EP300, NXF1, CIITA, LSM4, LSM5, POLR2E, THRA, SRA1, SMURF1, POLR2C, HNF4A, FBXO25, SLC22A2, HMGCL, JAK3, DEPDC7, TNIP1, DRAP1, IGKC, SERPINB1, AMY1C, CST4, CST1, CST2, PIGR, NME2P1, ZG16B, MUC7, IGHA1, PRB1, OXSM, ALKBH2, FBL, NAP1L1, NSUN2, PRPF18, RFC5, MED4, POLR2F, POLR2G, RPL10, DUSP6, IGJBPI


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GTF2B_BPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GTF2B_BPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource