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Fusion gene ID: 15600 |
FusionGeneSummary for GSTT1_SLC2A11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GSTT1_SLC2A11 | Fusion gene ID: 15600 | Hgene | Tgene | Gene symbol | GSTT1 | SLC2A11 | Gene ID | 2952 | 66035 |
| Gene name | glutathione S-transferase theta 1 | solute carrier family 2 member 11 | |
| Synonyms | - | GLUT10|GLUT11 | |
| Cytomap | 22q11.23 | 22q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutathione S-transferase theta-1GST class-theta-1glutathione transferase T1-1 | solute carrier family 2, facilitated glucose transporter member 11facilitative glucose transporter GLUT11glucose transporter protein 10glucose transporter protein 11glucose transporter type 10glucose transporter type 11glucose transporter-like prote | |
| Modification date | 20180527 | 20180329 | |
| UniProtAcc | P30711 | Q9BYW1 | |
| Ensembl transtripts involved in fusion gene | ENST00000248935, ENST00000439996, | ENST00000345044, ENST00000403208, ENST00000398356, ENST00000405847, ENST00000467660, ENST00000316185, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: GSTT1 [Title/Abstract] AND SLC2A11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GSTT1 | GO:0006749 | glutathione metabolic process | 9307035|9434735|20097269 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN352897 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000248935 | ENST00000345044 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5CDS-intron | ENST00000248935 | ENST00000403208 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5CDS-intron | ENST00000248935 | ENST00000398356 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5CDS-intron | ENST00000248935 | ENST00000405847 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5CDS-3UTR | ENST00000248935 | ENST00000467660 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5CDS-3UTR | ENST00000248935 | ENST00000316185 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5UTR-3CDS | ENST00000439996 | ENST00000345044 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5UTR-intron | ENST00000439996 | ENST00000403208 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5UTR-intron | ENST00000439996 | ENST00000398356 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5UTR-intron | ENST00000439996 | ENST00000405847 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5UTR-3UTR | ENST00000439996 | ENST00000467660 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
| 5UTR-3UTR | ENST00000439996 | ENST00000316185 | GSTT1 | chr22 | 24384119 | - | SLC2A11 | chr22 | 24217301 | + |
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FusionProtFeatures for GSTT1_SLC2A11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GSTT1 | SLC2A11 |
| Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displaysglutathione peroxidase activity with cumene hydroperoxide.{ECO:0000269|PubMed:16298388, ECO:0000269|PubMed:20097269}. | Facilitative glucose transporter.{ECO:0000269|PubMed:12175779}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GSTT1_SLC2A11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GSTT1_SLC2A11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GSTT1 | GSTO1, ATOX1, CSTB, FKBP1A, HINT1, EGFR, MID1, MYLK2, HBB, SIRT2, PRSS2, SPRTN, LRP2BP, HBA2, LURAP1, ZMAT5 | SLC2A11 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSTT1_SLC2A11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GSTT1 | P30711 | DB00143 | Glutathione | Glutathione S-transferase theta-1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GSTT1_SLC2A11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GSTT1 | C0036341 | Schizophrenia | 5 | PSYGENET |
| Hgene | GSTT1 | C0033578 | Prostatic Neoplasms | 4 | CTD_human |
| Hgene | GSTT1 | C0008625 | Chromosome Aberrations | 3 | CTD_human |
| Hgene | GSTT1 | C4277682 | Chemical and Drug Induced Liver Injury | 3 | CTD_human |
| Hgene | GSTT1 | C0236733 | Amphetamine-Related Disorders | 2 | CTD_human |
| Hgene | GSTT1 | C0003949 | Asbestosis | 1 | CTD_human |
| Hgene | GSTT1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | GSTT1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | GSTT1 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | GSTT1 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | GSTT1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | GSTT1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | GSTT1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Hgene | GSTT1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | GSTT1 | C0026764 | Multiple Myeloma | 1 | CTD_human |
| Hgene | GSTT1 | C0034734 | Raynaud Disease | 1 | CTD_human |
| Hgene | GSTT1 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| Hgene | GSTT1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | GSTT1 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Hgene | GSTT1 | C0403823 | Asthenozoospermia | 1 | CTD_human |
| Hgene | GSTT1 | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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