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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15574

FusionGeneSummary for GSR_RBPMS

check button Fusion gene summary
Fusion gene informationFusion gene name: GSR_RBPMS
Fusion gene ID: 15574
HgeneTgene
Gene symbol

GSR

RBPMS

Gene ID

2936

11030

Gene nameglutathione-disulfide reductaseRNA binding protein, mRNA processing factor
SynonymsGR|HEL-75|HEL-S-122mHERMES
Cytomap

8p12

8p12

Type of geneprotein-codingprotein-coding
Descriptionglutathione reductase, mitochondrialGRaseepididymis luminal protein 75epididymis secretory sperm binding protein Li 122mglutathione S-reductaseRNA-binding protein with multiple splicingRNA binding protein with multiple splicingheart and RRM expressed sequence
Modification date2018052320180523
UniProtAcc

P00390

Q93062

Ensembl transtripts involved in fusion geneENST00000221130, ENST00000414019, 
ENST00000546342, ENST00000537535, 
ENST00000541648, 
ENST00000538486, 
ENST00000397323, ENST00000320203, 
ENST00000287771, ENST00000339877, 
ENST00000517860, ENST00000520161, 
ENST00000519647, ENST00000520191, 
ENST00000520916, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 7 X 4=196
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSR [Title/Abstract] AND RBPMS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBPMS

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

17099224

TgeneRBPMS

GO:0060391

positive regulation of SMAD protein signal transduction

17099224


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-5521-01AGSRchr8

30585047

-RBPMSchr8

30416404

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000221130ENST00000538486GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000221130ENST00000397323GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000221130ENST00000320203GSRchr8

30585047

-RBPMSchr8

30416404

+
In-frameENST00000221130ENST00000287771GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000221130ENST00000339877GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000221130ENST00000517860GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000221130ENST00000520161GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000221130ENST00000519647GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000221130ENST00000520191GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000221130ENST00000520916GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000414019ENST00000538486GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000414019ENST00000397323GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000414019ENST00000320203GSRchr8

30585047

-RBPMSchr8

30416404

+
In-frameENST00000414019ENST00000287771GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000414019ENST00000339877GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000414019ENST00000517860GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000414019ENST00000520161GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000414019ENST00000519647GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000414019ENST00000520191GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000414019ENST00000520916GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000546342ENST00000538486GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000546342ENST00000397323GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000546342ENST00000320203GSRchr8

30585047

-RBPMSchr8

30416404

+
In-frameENST00000546342ENST00000287771GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000546342ENST00000339877GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000546342ENST00000517860GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000546342ENST00000520161GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000546342ENST00000519647GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000546342ENST00000520191GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000546342ENST00000520916GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000537535ENST00000538486GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000537535ENST00000397323GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000537535ENST00000320203GSRchr8

30585047

-RBPMSchr8

30416404

+
In-frameENST00000537535ENST00000287771GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000537535ENST00000339877GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000537535ENST00000517860GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000537535ENST00000520161GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000537535ENST00000519647GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000537535ENST00000520191GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000537535ENST00000520916GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000541648ENST00000538486GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000541648ENST00000397323GSRchr8

30585047

-RBPMSchr8

30416404

+
Frame-shiftENST00000541648ENST00000320203GSRchr8

30585047

-RBPMSchr8

30416404

+
In-frameENST00000541648ENST00000287771GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000541648ENST00000339877GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000541648ENST00000517860GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000541648ENST00000520161GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000541648ENST00000519647GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000541648ENST00000520191GSRchr8

30585047

-RBPMSchr8

30416404

+
5CDS-intronENST00000541648ENST00000520916GSRchr8

30585047

-RBPMSchr8

30416404

+

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FusionProtFeatures for GSR_RBPMS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSR

P00390

RBPMS

Q93062

Maintains high levels of reduced glutathione in thecytosol. Acts as a coactivator of transcriptional activity.Required to increase TGFB1/Smad-mediated transactivation. Actsthrough SMAD2, SMAD3 and SMAD4 to increase transcriptionalactivity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1.Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224,PubMed:26347403). {ECO:0000269|PubMed:17099224,ECO:0000269|PubMed:26347403}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GSR_RBPMS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GSR_ENST00000221130_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA

>In-frame_GSR_ENST00000414019_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_59aa

>In-frame_GSR_ENST00000546342_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA

>In-frame_GSR_ENST00000537535_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA

>In-frame_GSR_ENST00000541648_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GSR_ENST00000221130_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC

>In-frame_GSR_ENST00000414019_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_178nt
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC

>In-frame_GSR_ENST00000546342_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC

>In-frame_GSR_ENST00000537535_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC

>In-frame_GSR_ENST00000541648_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_GSR_ENST00000221130_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2191nt
GTGAGGCTGCGCTTGCCCGGGGCCCGCGCCCCCCTACCCCGGGGACCGCCCCCGGGCCGCCCGCCCCACTTGGCGCGCCACTTCCGCGTG
CATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCT
GCCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGG
CGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGC
CGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCA
GTTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTC
TCTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCAC
ACATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTG
TGAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGT
ATTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTG
TAATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTG
TGAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTG
TTAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAA
CTGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCC
AAGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCAT
CCCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTG
GCTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCT
GGTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCA
CACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGA
CACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAA
CACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTT
CCATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATA
AGGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTG
GTGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTT

>In-frame_GSR_ENST00000414019_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_1971nt
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC
TCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATG
CGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAGTTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCT
GCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCTCTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAA
ACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACACATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAA
ATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGTGAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATAT
TTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTATTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGA
TCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGTAATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGC
ATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGTGAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTA
AATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGTTAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAA
GACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAACTGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTG
CCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCAAGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGT
ATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATCCCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGG
TAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGGCTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGT
CTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTGGTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCA
CATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCACACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAA
TTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGACACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTG
TACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAACACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAA
TTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTCCATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTC
AACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAAGGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCC
ACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGGTGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGC

>In-frame_GSR_ENST00000546342_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2100nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAG
TTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCT
CTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACA
CATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGT
GAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTA
TTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGT
AATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGT
GAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGT
TAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAAC
TGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCA
AGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATC
CCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGG
CTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTG
GTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCAC
ACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGAC
ACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAAC
ACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTC
CATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAA
GGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGG
TGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTTT

>In-frame_GSR_ENST00000537535_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2100nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAG
TTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCT
CTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACA
CATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGT
GAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTA
TTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGT
AATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGT
GAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGT
TAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAAC
TGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCA
AGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATC
CCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGG
CTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTG
GTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCAC
ACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGAC
ACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAAC
ACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTC
CATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAA
GGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGG
TGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTTT

>In-frame_GSR_ENST00000541648_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2100nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAG
TTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCT
CTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACA
CATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGT
GAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTA
TTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGT
AATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGT
GAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGT
TAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAAC
TGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCA
AGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATC
CCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGG
CTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTG
GTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCAC
ACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGAC
ACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAAC
ACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTC
CATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAA
GGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGG
TGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTTT


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FusionGenePPI for GSR_RBPMS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GSRPJA1, GSR, ELAVL1, ISG15, FOLR1, C11orf49, ADSS, CNDP2, DDX39A, EEF2, GBP2, GINS2, AHSA1, DDX39B, LDHA, NDRG1, PROSC, HSPD1, KYNU, MVD, NAMPT, PEPD, RPS6KA1, AIFM1, ASS1, FDXR, PIR, LSM12, TOMM40, NTRK1, MCM2RBPMSSTRBP, DTX2, TOLLIP, LZTS2, FOXS1, FXR2, ZC3H10, RHOXF2, CDC42EP1, PDLIM4, C1orf94, RABL6, GRAP2, PHF1, RBPMS, ARHGEF39, EWSR1, LRRC41, CCNK, ZNF581, GSE1, CDC23, CCER1, TRIP13, FASTK, HOXA9, PITX1, SERF2, SF1, TEX37, FAM103A1, EYA2, ARHGAP9, PIN1, DVL2, RBFOX2, SMUG1, HOXB9, NEU4, HEYL, CNNM3, POM121, OTX1, ENKD1, DAZAP2, ATN1, ATXN1, ATXN1L, QKI, VHL, RBFOX1, KIF1A, MVP, PER1, PRKAB2, TBX6, AES, BBS2, CAMK2B, CCNG1, CRYBA1, CSN3, CYBA, FOXC2, GPS2, HOXA1, IGF2, ILF3, KIR2DL4, KPNA2, KRAS, MCM5, NAB2, NEDD9, ROR2, PRKAA1, PRKAA2, SNRPB, SNRPC, SPG7, TIE1, TMSB4X, LMO4, BHLHE40, ADAM15, APLN, GCM2, MAGED1, CREB5, AMMECR1, NR1D2, SIRPB1, TFG, DPYSL4, GRAP, ARID5A, TUSC2, RHOBTB3, R3HDM2, POGZ, FAM168A, HEY2, RUSC1, PGLS, LINC00588, ZBTB32, VENTX, EFEMP2, DCAF8, FOXP3, CRBN, PLAC8, IP6K2, MYOZ2, KCTD9, BANP, PIH1D1, VPS37C, WDYHV1, GPATCH2L, NYNRIN, SEMA4G, INIP, DMRT3, TINAGL1, BOLL, C20orf195, FAM124B, DOK3, FBXL18, SBF2, YPEL3, WDR54, DCTN5, LINC01547, C9orf24, FBF1, LONRF1, RIPPLY1, HNRNPLL, NAPRT, ZNF488, PRR20A, LRRC75A-AS1, C22orf39, GLYCTK, LOC142937, RDH12, SPATA8, MGAT5B, LOC148413, DCDC2B, SH3RF2, ATP6V0E2, TOR1AIP2, PAPD4, WDR90, ZNF385C, DOK6, TTLL10, CSNK1G2-AS1, BCL6B, LINC01588, LINC00482, LINC00908, C1orf111, RTP5, KRTAP8-1, KRTAP23-1, KRTAP19-5, KRTAP19-7, KRTAP12-2, INCA1, VHLL, C11orf87, LGALS9C, PRMT2, OLFM4, RBM46, RAD54L2, FRG1, GATAD2B, BUB1, MYH9, HYPK, RBPMS2, HAO2, ESRP1, HTRA4, GSTZ1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSR_RBPMS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSRP00390DB00262CarmustineGlutathione reductase, mitochondrialsmall moleculeapproved|investigational
HgeneGSRP00390DB00143GlutathioneGlutathione reductase, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GSR_RBPMS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSRC0002736Amyotrophic Lateral Sclerosis1CTD_human
HgeneGSRC0002871Anemia1CTD_human
HgeneGSRC0002878Anemia, Hemolytic1CTD_human
HgeneGSRC0011616Contact Dermatitis1CTD_human
HgeneGSRC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneGSRC0013604Edema1CTD_human
HgeneGSRC0020550Hyperthyroidism1CTD_human
HgeneGSRC0020615Hypoglycemia1CTD_human
HgeneGSRC0033626Protein Deficiency1CTD_human
HgeneGSRC0242422Parkinsonian Disorders1CTD_human
HgeneGSRC0524851Neurodegenerative Disorders1CTD_human
HgeneGSRC1456865Ureteral Calculi1CTD_human
HgeneGSRC4277682Chemical and Drug Induced Liver Injury1CTD_human