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Fusion gene ID: 15574 |
FusionGeneSummary for GSR_RBPMS |
Fusion gene summary |
Fusion gene information | Fusion gene name: GSR_RBPMS | Fusion gene ID: 15574 | Hgene | Tgene | Gene symbol | GSR | RBPMS | Gene ID | 2936 | 11030 |
Gene name | glutathione-disulfide reductase | RNA binding protein, mRNA processing factor | |
Synonyms | GR|HEL-75|HEL-S-122m | HERMES | |
Cytomap | 8p12 | 8p12 | |
Type of gene | protein-coding | protein-coding | |
Description | glutathione reductase, mitochondrialGRaseepididymis luminal protein 75epididymis secretory sperm binding protein Li 122mglutathione S-reductase | RNA-binding protein with multiple splicingRNA binding protein with multiple splicingheart and RRM expressed sequence | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P00390 | Q93062 | |
Ensembl transtripts involved in fusion gene | ENST00000221130, ENST00000414019, ENST00000546342, ENST00000537535, ENST00000541648, | ENST00000538486, ENST00000397323, ENST00000320203, ENST00000287771, ENST00000339877, ENST00000517860, ENST00000520161, ENST00000519647, ENST00000520191, ENST00000520916, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 7 X 7 X 4=196 |
# samples | 4 | 8 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GSR [Title/Abstract] AND RBPMS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RBPMS | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 17099224 |
Tgene | RBPMS | GO:0060391 | positive regulation of SMAD protein signal transduction | 17099224 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-EJ-5521-01A | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000221130 | ENST00000538486 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000221130 | ENST00000397323 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000221130 | ENST00000320203 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
In-frame | ENST00000221130 | ENST00000287771 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000221130 | ENST00000339877 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000221130 | ENST00000517860 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000221130 | ENST00000520161 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000221130 | ENST00000519647 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000221130 | ENST00000520191 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000221130 | ENST00000520916 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000414019 | ENST00000538486 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000414019 | ENST00000397323 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000414019 | ENST00000320203 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
In-frame | ENST00000414019 | ENST00000287771 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000414019 | ENST00000339877 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000414019 | ENST00000517860 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000414019 | ENST00000520161 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000414019 | ENST00000519647 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000414019 | ENST00000520191 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000414019 | ENST00000520916 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000546342 | ENST00000538486 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000546342 | ENST00000397323 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000546342 | ENST00000320203 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
In-frame | ENST00000546342 | ENST00000287771 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000546342 | ENST00000339877 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000546342 | ENST00000517860 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000546342 | ENST00000520161 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000546342 | ENST00000519647 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000546342 | ENST00000520191 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000546342 | ENST00000520916 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000537535 | ENST00000538486 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000537535 | ENST00000397323 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000537535 | ENST00000320203 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
In-frame | ENST00000537535 | ENST00000287771 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000537535 | ENST00000339877 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000537535 | ENST00000517860 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000537535 | ENST00000520161 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000537535 | ENST00000519647 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000537535 | ENST00000520191 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000537535 | ENST00000520916 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000541648 | ENST00000538486 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000541648 | ENST00000397323 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
Frame-shift | ENST00000541648 | ENST00000320203 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
In-frame | ENST00000541648 | ENST00000287771 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000541648 | ENST00000339877 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000541648 | ENST00000517860 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000541648 | ENST00000520161 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000541648 | ENST00000519647 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000541648 | ENST00000520191 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
5CDS-intron | ENST00000541648 | ENST00000520916 | GSR | chr8 | 30585047 | - | RBPMS | chr8 | 30416404 | + |
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FusionProtFeatures for GSR_RBPMS |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GSR | RBPMS |
Maintains high levels of reduced glutathione in thecytosol. | Acts as a coactivator of transcriptional activity.Required to increase TGFB1/Smad-mediated transactivation. Actsthrough SMAD2, SMAD3 and SMAD4 to increase transcriptionalactivity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1.Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224,PubMed:26347403). {ECO:0000269|PubMed:17099224,ECO:0000269|PubMed:26347403}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GSR_RBPMS |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GSR_ENST00000221130_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA >In-frame_GSR_ENST00000414019_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_59aa >In-frame_GSR_ENST00000546342_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA >In-frame_GSR_ENST00000537535_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA >In-frame_GSR_ENST00000541648_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_102aa MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GSR_ENST00000221130_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC >In-frame_GSR_ENST00000414019_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_178nt ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC >In-frame_GSR_ENST00000546342_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC >In-frame_GSR_ENST00000537535_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC >In-frame_GSR_ENST00000541648_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_307nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GSR_ENST00000221130_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2191nt GTGAGGCTGCGCTTGCCCGGGGCCCGCGCCCCCCTACCCCGGGGACCGCCCCCGGGCCGCCCGCCCCACTTGGCGCGCCACTTCCGCGTG CATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCT GCCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGG CGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGC CGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCA GTTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTC TCTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCAC ACATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTG TGAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGT ATTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTG TAATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTG TGAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTG TTAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAA CTGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCC AAGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCAT CCCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTG GCTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCT GGTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCA CACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGA CACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAA CACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTT CCATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATA AGGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTG GTGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTT >In-frame_GSR_ENST00000414019_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_1971nt ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC TCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATG CGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAGTTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCT GCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCTCTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAA ACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACACATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAA ATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGTGAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATAT TTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTATTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGA TCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGTAATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGC ATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGTGAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTA AATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGTTAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAA GACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAACTGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTG CCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCAAGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGT ATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATCCCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGG TAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGGCTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGT CTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTGGTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCA CATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCACACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAA TTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGACACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTG TACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAACACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAA TTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTCCATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTC AACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAAGGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCC ACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGGTGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGC >In-frame_GSR_ENST00000546342_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2100nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAG TTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCT CTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACA CATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGT GAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTA TTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGT AATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGT GAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGT TAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAAC TGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCA AGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATC CCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGG CTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTG GTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCAC ACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGAC ACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAAC ACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTC CATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAA GGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGG TGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTTT >In-frame_GSR_ENST00000537535_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2100nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAG TTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCT CTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACA CATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGT GAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTA TTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGT AATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGT GAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGT TAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAAC TGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCA AGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATC CCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGG CTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTG GTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCAC ACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGAC ACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAAC ACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTC CATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAA GGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGG TGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTTT >In-frame_GSR_ENST00000541648_chr8_30585047_-_RBPMS_ENST00000287771_chr8_30416404_+_2100nt ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAG TTCTGCTGAATACTATGTCCCAGGTGTGTGATGGCGGCTGCAATCTGTCTTGTGGGTATTAATGCAATCTTCAGTGGTGGCTACTGTTCT CTAGCTGTTCTACAAAACTGGAGCATGCTGGCTTGAAAAACCCTTGCCCAGTTTTGATCCCTTCAAGACTTTGTCACAGCCTCTATCACA CATCTGTTTTTCTCGAAGAAAAAAATATAATTAATAAAAATGTTTTACTCTTTTACACTGTATAATTGTAAGAAATAGCGTATTATTTGT GAATGCATGGTCTGAAATTTCTGTACAGTTTGGAGATATTTTCAAACGAAACGTAAGAGAAGTCAACAATAAAACCAAGAAAAGTGAGTA TTTTTATACCAAACATTTTAAGTATGCTGGGATGGACGATCTTACACTGGTTTGGATCACAGTTTTTGTTCTTGACTTTTGAATGCTTGT AATTAAAAATATCTATTTTTTTCCTCTGAAGTAAGTTGCATGTTTGAGGCATGTTTCCAAATATTATCAAAATATCCTGAATTGTATTGT GAATATATAGAAATCTGTGCCTGGCCGGAGTCCAGGGTAAATTAGTAGCATGGTGTTAGATGTTAGAAACAGAACTGTTATTTGCAGTGT TAGGTCTAGGATCCCAGTTCTAGTAGGACAGCCCTGCAAGACAATCAACCAGAAGCCTCCAGGAGCTTCTACCTATGGCTTATTCACAAC TGGGCAAGAAAACATCATTGGTAAGAACTGCTGAGTGTGCCCTTAGAAAGCCCTAGTAGCTCCAGCTGTGACTATATCAACTGTGTGCCA AGTGTGACTTTGTACAGTTTTATGTTTCCACTCTCCTGTATGTGTAGCCACTCGATGCCTAACCTACCTTCCACAAGCCAGCCCCGCATC CCTGCTCCCGCAGTGTAAGTGCAGAGCCTGCCTCACTGGTAAGGGAAAACCTTGGCTTGGGAGGCCAGCCCTGGCCCTTGAAGGGGTTGG CTGTGCCCAGCCCACCTGGCTGCAGTGGGCAGCTCATGTCTGTATCTCCAAAGTGATGTTTGTTTGCAAAACACCGGCTGAACTGAGCTG GTGTTGCCAACTCTTGGCAGCACTGGGCCAAACCGACCACATACCATGAGCTCCCAAATGGCGTGTGCTCACTGTGAGACGTCCTGCCAC ACCCCACAGGAGACGGAGGCAGTGGGCATTTGGAACCAATTCTATTCAGACTTCGTCAAAGCCAAAGTCAGTCTGGTGTTGTCAGTTGAC ACATCTCCAGAGTTCATGACAGCTCAACCTCTCCCCTTGTACAGAAGCCATTTTTGTAAAACCACACTGACCTAAATTCAGCTGCCAAAC ACAGTCTTTCCTATTGATCCGCTCGGCTTATGTTGAAAATTTCAATGTCATGATTACCTGGTTGGTTTGGGTTTTTGTTTTGTTATTTTC CATTAGAAATATAAAGATGTCAAGAAGCTTTTAAAGGTCAACACAAAAAACCAAGGCCAGGAGTGAGGGGCTCTTTCTTACCGTAAATAA GGGGAAAAGGCAGTTAGCTCAAGGACTTGTGACGGATCCACTTTGGTGTTCAAGGACCTGCTTATGCCCTCAGTGCCAATCGGCTCTTGG TGAGATGACTGTACTCCTAAGGAAAATAGCCACTTCTGCAGTCTATTATGCTTTTATAACTGTTTAAAGGTACTTTTCTATTGTCATTTT |
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FusionGenePPI for GSR_RBPMS |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GSR | PJA1, GSR, ELAVL1, ISG15, FOLR1, C11orf49, ADSS, CNDP2, DDX39A, EEF2, GBP2, GINS2, AHSA1, DDX39B, LDHA, NDRG1, PROSC, HSPD1, KYNU, MVD, NAMPT, PEPD, RPS6KA1, AIFM1, ASS1, FDXR, PIR, LSM12, TOMM40, NTRK1, MCM2 | RBPMS | STRBP, DTX2, TOLLIP, LZTS2, FOXS1, FXR2, ZC3H10, RHOXF2, CDC42EP1, PDLIM4, C1orf94, RABL6, GRAP2, PHF1, RBPMS, ARHGEF39, EWSR1, LRRC41, CCNK, ZNF581, GSE1, CDC23, CCER1, TRIP13, FASTK, HOXA9, PITX1, SERF2, SF1, TEX37, FAM103A1, EYA2, ARHGAP9, PIN1, DVL2, RBFOX2, SMUG1, HOXB9, NEU4, HEYL, CNNM3, POM121, OTX1, ENKD1, DAZAP2, ATN1, ATXN1, ATXN1L, QKI, VHL, RBFOX1, KIF1A, MVP, PER1, PRKAB2, TBX6, AES, BBS2, CAMK2B, CCNG1, CRYBA1, CSN3, CYBA, FOXC2, GPS2, HOXA1, IGF2, ILF3, KIR2DL4, KPNA2, KRAS, MCM5, NAB2, NEDD9, ROR2, PRKAA1, PRKAA2, SNRPB, SNRPC, SPG7, TIE1, TMSB4X, LMO4, BHLHE40, ADAM15, APLN, GCM2, MAGED1, CREB5, AMMECR1, NR1D2, SIRPB1, TFG, DPYSL4, GRAP, ARID5A, TUSC2, RHOBTB3, R3HDM2, POGZ, FAM168A, HEY2, RUSC1, PGLS, LINC00588, ZBTB32, VENTX, EFEMP2, DCAF8, FOXP3, CRBN, PLAC8, IP6K2, MYOZ2, KCTD9, BANP, PIH1D1, VPS37C, WDYHV1, GPATCH2L, NYNRIN, SEMA4G, INIP, DMRT3, TINAGL1, BOLL, C20orf195, FAM124B, DOK3, FBXL18, SBF2, YPEL3, WDR54, DCTN5, LINC01547, C9orf24, FBF1, LONRF1, RIPPLY1, HNRNPLL, NAPRT, ZNF488, PRR20A, LRRC75A-AS1, C22orf39, GLYCTK, LOC142937, RDH12, SPATA8, MGAT5B, LOC148413, DCDC2B, SH3RF2, ATP6V0E2, TOR1AIP2, PAPD4, WDR90, ZNF385C, DOK6, TTLL10, CSNK1G2-AS1, BCL6B, LINC01588, LINC00482, LINC00908, C1orf111, RTP5, KRTAP8-1, KRTAP23-1, KRTAP19-5, KRTAP19-7, KRTAP12-2, INCA1, VHLL, C11orf87, LGALS9C, PRMT2, OLFM4, RBM46, RAD54L2, FRG1, GATAD2B, BUB1, MYH9, HYPK, RBPMS2, HAO2, ESRP1, HTRA4, GSTZ1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSR_RBPMS |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GSR | P00390 | DB00262 | Carmustine | Glutathione reductase, mitochondrial | small molecule | approved|investigational |
Hgene | GSR | P00390 | DB00143 | Glutathione | Glutathione reductase, mitochondrial | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GSR_RBPMS |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GSR | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Hgene | GSR | C0002871 | Anemia | 1 | CTD_human |
Hgene | GSR | C0002878 | Anemia, Hemolytic | 1 | CTD_human |
Hgene | GSR | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | GSR | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | GSR | C0013604 | Edema | 1 | CTD_human |
Hgene | GSR | C0020550 | Hyperthyroidism | 1 | CTD_human |
Hgene | GSR | C0020615 | Hypoglycemia | 1 | CTD_human |
Hgene | GSR | C0033626 | Protein Deficiency | 1 | CTD_human |
Hgene | GSR | C0242422 | Parkinsonian Disorders | 1 | CTD_human |
Hgene | GSR | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
Hgene | GSR | C1456865 | Ureteral Calculi | 1 | CTD_human |
Hgene | GSR | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |