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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15573

FusionGeneSummary for GSR_OTOA

check button Fusion gene summary
Fusion gene informationFusion gene name: GSR_OTOA
Fusion gene ID: 15573
HgeneTgene
Gene symbol

GSR

OTOA

Gene ID

2936

146183

Gene nameglutathione-disulfide reductaseotoancorin
SynonymsGR|HEL-75|HEL-S-122mCT108|DFNB22
Cytomap

8p12

16p12.2|16p12.2

Type of geneprotein-codingprotein-coding
Descriptionglutathione reductase, mitochondrialGRaseepididymis luminal protein 75epididymis secretory sperm binding protein Li 122mglutathione S-reductaseotoancorincancer/testis antigen 108
Modification date2018052320180523
UniProtAcc

P00390

Q7RTW8

Ensembl transtripts involved in fusion geneENST00000221130, ENST00000414019, 
ENST00000546342, ENST00000537535, 
ENST00000541648, 
ENST00000286149, 
ENST00000388958, ENST00000388956, 
ENST00000388957, ENST00000569064, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 3=48
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSR [Title/Abstract] AND OTOA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-94-7943-01AGSRchr8

30550486

-OTOAchr16

21771791

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000221130ENST00000286149GSRchr8

30550486

-OTOAchr16

21771791

+
In-frameENST00000221130ENST00000388958GSRchr8

30550486

-OTOAchr16

21771791

+
In-frameENST00000221130ENST00000388956GSRchr8

30550486

-OTOAchr16

21771791

+
Frame-shiftENST00000221130ENST00000388957GSRchr8

30550486

-OTOAchr16

21771791

+
5CDS-intronENST00000221130ENST00000569064GSRchr8

30550486

-OTOAchr16

21771791

+
Frame-shiftENST00000414019ENST00000286149GSRchr8

30550486

-OTOAchr16

21771791

+
In-frameENST00000414019ENST00000388958GSRchr8

30550486

-OTOAchr16

21771791

+
In-frameENST00000414019ENST00000388956GSRchr8

30550486

-OTOAchr16

21771791

+
Frame-shiftENST00000414019ENST00000388957GSRchr8

30550486

-OTOAchr16

21771791

+
5CDS-intronENST00000414019ENST00000569064GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000546342ENST00000286149GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000546342ENST00000388958GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000546342ENST00000388956GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000546342ENST00000388957GSRchr8

30550486

-OTOAchr16

21771791

+
intron-intronENST00000546342ENST00000569064GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000537535ENST00000286149GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000537535ENST00000388958GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000537535ENST00000388956GSRchr8

30550486

-OTOAchr16

21771791

+
intron-3CDSENST00000537535ENST00000388957GSRchr8

30550486

-OTOAchr16

21771791

+
intron-intronENST00000537535ENST00000569064GSRchr8

30550486

-OTOAchr16

21771791

+
Frame-shiftENST00000541648ENST00000286149GSRchr8

30550486

-OTOAchr16

21771791

+
In-frameENST00000541648ENST00000388958GSRchr8

30550486

-OTOAchr16

21771791

+
In-frameENST00000541648ENST00000388956GSRchr8

30550486

-OTOAchr16

21771791

+
Frame-shiftENST00000541648ENST00000388957GSRchr8

30550486

-OTOAchr16

21771791

+
5CDS-intronENST00000541648ENST00000569064GSRchr8

30550486

-OTOAchr16

21771791

+

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FusionProtFeatures for GSR_OTOA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSR

P00390

OTOA

Q7RTW8

Maintains high levels of reduced glutathione in thecytosol. May act as an adhesion molecule.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GSR_OTOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GSR_ENST00000221130_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_317aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA
AVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF

>In-frame_GSR_ENST00000221130_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_317aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA
AVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF

>In-frame_GSR_ENST00000414019_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_274aa
MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPS
CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG
FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQELSSRGVFGLVVPCWFXWP

>In-frame_GSR_ENST00000414019_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_274aa
MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPS
CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG
FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQELSSRGVFGLVVPCWFXWP

>In-frame_GSR_ENST00000541648_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_317aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA
AVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF

>In-frame_GSR_ENST00000541648_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_317aa
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA
AVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GSR_ENST00000221130_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_953nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCT
GAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTAT
GTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCC
AAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGC
CAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGT
TACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTT
GATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGG

>In-frame_GSR_ENST00000221130_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_953nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCT
GAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTAT
GTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCC
AAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGC
CAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGT
TACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTT
GATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGG

>In-frame_GSR_ENST00000414019_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_824nt
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC
TCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGT
TGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCC
CCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTG
GGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGGGTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCA

>In-frame_GSR_ENST00000414019_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_824nt
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC
TCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGT
TGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCC
CCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTG
GGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGGGTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCA

>In-frame_GSR_ENST00000541648_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_953nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCT
GAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTAT
GTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCC
AAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGC
CAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGT
TACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTT
GATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGG

>In-frame_GSR_ENST00000541648_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_953nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCT
GAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTAT
GTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCC
AAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGC
CAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGT
TACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTT
GATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GSR_ENST00000221130_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_1233nt
GTGAGGCTGCGCTTGCCCGGGGCCCGCGCCCCCCTACCCCGGGGACCGCCCCCGGGCCGCCCGCCCCACTTGGCGCGCCACTTCCGCGTG
CATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCT
GCCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGG
CGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGC
CGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTC
TGAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTA
TGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCC
CAAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAG
CCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGG
TTACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTT
TGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGG
GGTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCAAGCTCCTGTGGTGAGTGGCCTGAGCGCATCGTCCTGTGTTGCCCCAAGCA
GCTGGCCAACATGTGTAGAGACAGGATGCTCCAGATGGTGGGACACCCTTCCCTGGATCCAGACCCTCATCTAGGGCAGGGAAACCCTGG

>In-frame_GSR_ENST00000221130_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_1233nt
GTGAGGCTGCGCTTGCCCGGGGCCCGCGCCCCCCTACCCCGGGGACCGCCCCCGGGCCGCCCGCCCCACTTGGCGCGCCACTTCCGCGTG
CATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCT
GCCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGG
CGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGC
CGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTC
TGAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTA
TGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCC
CAAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAG
CCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGG
TTACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTT
TGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGG
GGTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCAAGCTCCTGTGGTGAGTGGCCTGAGCGCATCGTCCTGTGTTGCCCCAAGCA
GCTGGCCAACATGTGTAGAGACAGGATGCTCCAGATGGTGGGACACCCTTCCCTGGATCCAGACCCTCATCTAGGGCAGGGAAACCCTGG

>In-frame_GSR_ENST00000414019_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_1013nt
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC
TCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGT
TGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCC
CCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTG
GGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGGGTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCA
AGCTCCTGTGGTGAGTGGCCTGAGCGCATCGTCCTGTGTTGCCCCAAGCAGCTGGCCAACATGTGTAGAGACAGGATGCTCCAGATGGTG
GGACACCCTTCCCTGGATCCAGACCCTCATCTAGGGCAGGGAAACCCTGGGGCCTTGATGGTGAAAATGCACCCCAAATGAAAAATAATT

>In-frame_GSR_ENST00000414019_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_1013nt
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGC
TCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGT
TGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCC
CCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTG
GGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGGGTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCA
AGCTCCTGTGGTGAGTGGCCTGAGCGCATCGTCCTGTGTTGCCCCAAGCAGCTGGCCAACATGTGTAGAGACAGGATGCTCCAGATGGTG
GGACACCCTTCCCTGGATCCAGACCCTCATCTAGGGCAGGGAAACCCTGGGGCCTTGATGGTGAAAATGCACCCCAAATGAAAAATAATT

>In-frame_GSR_ENST00000541648_chr8_30550486_-_OTOA_ENST00000388958_chr16_21771791_+_1142nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCT
GAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTAT
GTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCC
AAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGC
CAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGT
TACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTT
GATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGG
GTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCAAGCTCCTGTGGTGAGTGGCCTGAGCGCATCGTCCTGTGTTGCCCCAAGCAG
CTGGCCAACATGTGTAGAGACAGGATGCTCCAGATGGTGGGACACCCTTCCCTGGATCCAGACCCTCATCTAGGGCAGGGAAACCCTGGG

>In-frame_GSR_ENST00000541648_chr8_30550486_-_OTOA_ENST00000388956_chr16_21771791_+_1142nt
ATGGCCCTGCTGCCCCGAGCCCTGAGCGCCGGCGCGGGACCGAGCTGGCGGCGGGCGGCGCGCGCCTTCCGAGGCTTCCTGCTGCTTCTG
CCCGAGCCCGCGGCCCTCACGCGCGCCCTCTCCCGTGCCATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGC
GCCGTGGCCTCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCGGCCGAGCTGGGTGCCAGGGCC
GCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTGAATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCT
GAATTCATGCATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATTAAGGAAAAGCGGGATGCCTAT
GTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACCAAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCC
AAGCCCACAATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATGCCCTCCACCCCTCATGAGAGC
CAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGATTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGT
TACATTGCTGTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCATGATAAGGTACTTAGAAGTTTT
GATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAGAACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGAGCTCTCCAGTCGTGGG
GTCTTTGGCTTGGTTGTCCCCTGCTGGTTCTAATGGCCAAGCTCCTGTGGTGAGTGGCCTGAGCGCATCGTCCTGTGTTGCCCCAAGCAG
CTGGCCAACATGTGTAGAGACAGGATGCTCCAGATGGTGGGACACCCTTCCCTGGATCCAGACCCTCATCTAGGGCAGGGAAACCCTGGG


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FusionGenePPI for GSR_OTOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GSRPJA1, GSR, ELAVL1, ISG15, FOLR1, C11orf49, ADSS, CNDP2, DDX39A, EEF2, GBP2, GINS2, AHSA1, DDX39B, LDHA, NDRG1, PROSC, HSPD1, KYNU, MVD, NAMPT, PEPD, RPS6KA1, AIFM1, ASS1, FDXR, PIR, LSM12, TOMM40, NTRK1, MCM2OTOA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSR_OTOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSRP00390DB00262CarmustineGlutathione reductase, mitochondrialsmall moleculeapproved|investigational
HgeneGSRP00390DB00143GlutathioneGlutathione reductase, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GSR_OTOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSRC0002736Amyotrophic Lateral Sclerosis1CTD_human
HgeneGSRC0002871Anemia1CTD_human
HgeneGSRC0002878Anemia, Hemolytic1CTD_human
HgeneGSRC0011616Contact Dermatitis1CTD_human
HgeneGSRC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneGSRC0013604Edema1CTD_human
HgeneGSRC0020550Hyperthyroidism1CTD_human
HgeneGSRC0020615Hypoglycemia1CTD_human
HgeneGSRC0033626Protein Deficiency1CTD_human
HgeneGSRC0242422Parkinsonian Disorders1CTD_human
HgeneGSRC0524851Neurodegenerative Disorders1CTD_human
HgeneGSRC1456865Ureteral Calculi1CTD_human
HgeneGSRC4277682Chemical and Drug Induced Liver Injury1CTD_human