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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15566

FusionGeneSummary for GSN_RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: GSN_RUNX1
Fusion gene ID: 15566
HgeneTgene
Gene symbol

GSN

RUNX1

Gene ID

2934

861

Gene namegelsolinrunt related transcription factor 1
SynonymsADF|AGELAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

9q33.2

21q22.12

Type of geneprotein-codingprotein-coding
Descriptiongelsolinactin-depolymerizing factorbrevinrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2018052220180527
UniProtAcc

P06396

Q01196

Ensembl transtripts involved in fusion geneENST00000373823, ENST00000373808, 
ENST00000436847, ENST00000449733, 
ENST00000412819, ENST00000394353, 
ENST00000341272, ENST00000545652, 
ENST00000373818, ENST00000485767, 
ENST00000373807, ENST00000373806, 
ENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
Fusion gene scores* DoF score15 X 11 X 7=115517 X 29 X 7=3451
# samples 1933
** MAII scorelog2(19/1155*10)=-2.60382152797247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3451*10)=-3.3864765441897
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSN [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSN

GO:0030041

actin filament polymerization

3020431

HgeneGSN

GO:0051014

actin filament severing

3020431

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE829610GSNchr9

124089088

+RUNX1chr21

36233848

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000373823ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373823ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373808ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000436847ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000449733ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000412819ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000394353ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000341272ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000545652ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373818ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000485767ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373807ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000344691GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000325074GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000437180GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000300305GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000399240GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000486278GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000494829GSNchr9

124089088

+RUNX1chr21

36233848

+
intron-intronENST00000373806ENST00000358356GSNchr9

124089088

+RUNX1chr21

36233848

+

Top

FusionProtFeatures for GSN_RUNX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSN

P06396

RUNX1

Q01196


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GSN_RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GSN_RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GSN_RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSNP06396DB01593ZincGelsolinsmall moleculeapproved|investigational

Top

RelatedDiseases for GSN_RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGSNC0025500Mesothelioma1CTD_human
HgeneGSNC0029456Osteoporosis1CTD_human
HgeneGSNC0030524Paratuberculosis1CTD_human
HgeneGSNC0036341Schizophrenia1PSYGENET
HgeneGSNC0043094Weight Gain1CTD_human
HgeneGSNC0948089Acute Coronary Syndrome1CTD_human
HgeneGSNC1622345Meretoja syndrome1CTD_human;ORPHANET;UNIPROT
HgeneGSNC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human