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Fusion gene ID: 15528 |
FusionGeneSummary for GSK3A_ZNF564 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GSK3A_ZNF564 | Fusion gene ID: 15528 | Hgene | Tgene | Gene symbol | GSK3A | ZNF564 | Gene ID | 2931 | 163050 |
| Gene name | glycogen synthase kinase 3 alpha | zinc finger protein 564 | |
| Synonyms | - | - | |
| Cytomap | 19q13.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycogen synthase kinase-3 alphaGSK-3 alphaserine/threonine-protein kinase GSK3A | zinc finger protein 564 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P49840 | Q8TBZ8 | |
| Ensembl transtripts involved in fusion gene | ENST00000222330, ENST00000398249, | ENST00000339282, ENST00000416136, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: GSK3A [Title/Abstract] AND ZNF564 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GSK3A | GO:0006468 | protein phosphorylation | 11035810 |
| Hgene | GSK3A | GO:0018107 | peptidyl-threonine phosphorylation | 25897075 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A8IH-01A | GSK3A | chr19 | 42744107 | - | ZNF564 | chr19 | 12639510 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000222330 | ENST00000339282 | GSK3A | chr19 | 42744107 | - | ZNF564 | chr19 | 12639510 | - |
| 5CDS-intron | ENST00000222330 | ENST00000416136 | GSK3A | chr19 | 42744107 | - | ZNF564 | chr19 | 12639510 | - |
| In-frame | ENST00000398249 | ENST00000339282 | GSK3A | chr19 | 42744107 | - | ZNF564 | chr19 | 12639510 | - |
| 5CDS-intron | ENST00000398249 | ENST00000416136 | GSK3A | chr19 | 42744107 | - | ZNF564 | chr19 | 12639510 | - |
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FusionProtFeatures for GSK3A_ZNF564 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GSK3A | ZNF564 |
| Constitutively active protein kinase that acts as anegative regulator in the hormonal control of glucose homeostasis,Wnt signaling and regulation of transcription factors andmicrotubules, by phosphorylating and inactivating glycogensynthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1.Requires primed phosphorylation of the majority of its substrates.Contributes to insulin regulation of glycogen synthesis byphosphorylating and inhibiting GYS1 activity and hence glycogensynthesis. Regulates glycogen metabolism in liver, but not inmuscle. May also mediate the development of insulin resistance byregulating activation of transcription factors. In Wnt signaling,regulates the level and transcriptional activity of nuclearCTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP)processing and the generation of APP-derived amyloid plaques foundin Alzheimer disease. May be involved in the regulation ofreplication in pancreatic beta-cells. Is necessary for theestablishment of neuronal polarity and axon outgrowth. Throughphosphorylation of the anti-apoptotic protein MCL1, may controlcell apoptosis in response to growth factors deprivation.{ECO:0000269|PubMed:12761548, ECO:0000269|PubMed:17229088}. | May be involved in transcriptional regulation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GSK3A | chr19:42744107 | chr19:12639510 | ENST00000222330 | - | 2 | 11 | 3_83 | 157 | 484 | Compositional bias | Note=Gly-rich |
| Hgene | GSK3A | chr19:42744107 | chr19:12639510 | ENST00000222330 | - | 2 | 11 | 125_133 | 157 | 484 | Nucleotide binding | ATP |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 4_83 | 1 | 554 | Domain | KRAB |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 103_125 | 1 | 554 | Zinc finger | C2H2-type 1 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 141_163 | 1 | 554 | Zinc finger | C2H2-type 2 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 169_191 | 1 | 554 | Zinc finger | C2H2-type 3 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 197_219 | 1 | 554 | Zinc finger | C2H2-type 4 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 225_247 | 1 | 554 | Zinc finger | C2H2-type 5 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 253_275 | 1 | 554 | Zinc finger | C2H2-type 6 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 281_303 | 1 | 554 | Zinc finger | C2H2-type 7 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 309_331 | 1 | 554 | Zinc finger | C2H2-type 8 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 337_359 | 1 | 554 | Zinc finger | C2H2-type 9 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 365_387 | 1 | 554 | Zinc finger | C2H2-type 10 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 393_415 | 1 | 554 | Zinc finger | C2H2-type 11 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 421_443 | 1 | 554 | Zinc finger | C2H2-type 12 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 449_471 | 1 | 554 | Zinc finger | C2H2-type 13 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 477_499 | 1 | 554 | Zinc finger | C2H2-type 14 |
| Tgene | >ZNF564 | chr19:42744107 | chr19:12639510 | ENST00000339282 | - | 0 | 4 | 505_527 | 1 | 554 | Zinc finger | C2H2-type 15 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GSK3A | chr19:42744107 | chr19:12639510 | ENST00000222330 | - | 2 | 11 | 119_403 | 157 | 484 | Domain | Protein kinase |
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FusionGeneSequence for GSK3A_ZNF564 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GSK3A_ENST00000222330_chr19_42744107_-_ZNF564_ENST00000339282_chr19_12639510_-_710aa MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPG VKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKDSVASEDVAVNFTLEEWALLDPS QKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMH HSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGPYKCQECGK AFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFT NFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHM IKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGE >In-frame_GSK3A_ENST00000398249_chr19_42744107_-_ZNF564_ENST00000339282_chr19_12639510_-_628aa MGQWIVYPLCSPGDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKDSVASEDVAVNFTLE EWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECS LCGKVFMHHSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGP YKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQC GKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFIS LPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GSK3A_ENST00000222330_chr19_42744107_-_ZNF564_ENST00000339282_chr19_12639510_-_2130nt ATGAGCGGCGGCGGGCCTTCGGGAGGCGGCCCTGGGGGCTCGGGCAGGGCGCGGACTAGCTCGTTCGCGGAGCCCGGCGGCGGAGGCGGA GGAGGCGGCGGCGGCCCCGGAGGCTCGGCCTCCGGCCCAGGCGGCACCGGCGGCGGAAAGGCATCTGTCGGGGCCATGGGTGGGGGCGTC GGGGCCTCGAGCTCCGGGGGTGGACCCGGCGGCAGCGGCGGAGGAGGCAGCGGAGGCCCCGGCGCAGGCACTAGCTTCCCGCCGCCCGGG GTGAAGCTGGGCCGTGACAGCGGGAAGGTGACCACAGTCGTAGCCACTCTAGGCCAAGGCCCAGAGCGCTCCCAAGAAGTGGCTTACACG GACATCAAAGTGATTGGCAATGGCTCATTTGGGGTCGTGTACCAGGCACGGCTGGCAGAGACCAGGGAACTAGTCGCCATCAAGAAGGTT CTCCAGGACAAGAGGTTCAAGGACTCAGTGGCCTCTGAGGATGTGGCTGTGAACTTCACACTTGAGGAGTGGGCTTTGCTGGATCCTTCC CAGAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCTGTGTAGGAAAAAAATGGGAAGACCAGAGCATTGAAGAT TGGTACAAAAATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCAGTGAAAGTAAAGAATATGATCAATGTGGAGAAGCCTTC AGTCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGACCATGTGAATGTAGTTTGTGTGGGAAAGTCTTCATGCAT CATTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATGACTATCAGGAATATGGAGAGAAACCATATAAATGTAAG CAGTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAACTCACACTGGTGAGAAACCCTATGCATGTCCGGAATGT GGGAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACACTGGAGATGGACCATATAAATGTCAGGAATGTGGGAAA GCCTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGAATGTGCAAAAGCTTTC ATTTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGACCTTATAAATGTCAGGAATGTGGAAAAGCCTTTGACCGC CCCAGTTTATTTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATGAATGTAAACAGTGTGGGAAGGCCTTCATTTCTTTCACA AATTTTCAAAGTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTAAAGTATGTGGGAGAGCCTTTATTTTTCCCAGTTATGTT CGAAAGCATGAAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAATGTGGTAAAACCTTCAGTTCTTCCAGTAATGTTCGAACA CATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGAAAGCCTTCATTTCTCTCCCAAGTGTCCGAAGACACATG ATAAAGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCTTTGACTGTCCCAGTTCATTTCAAATACACGAAAGAACT CACACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTTCTCTTAAAAGGATTAGAAAACATATGATACTGCACACT GGAGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTAGTTCTGTCCGAACACATGAAAGAACTCATACTGGAGAA AAACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCATTAGAATACATGAAAGAACTCATACCGGAGAAAAACCC TATGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAAGACATGAAAGAGCTCATAATGGAGATAAACCTTACGTA >In-frame_GSK3A_ENST00000398249_chr19_42744107_-_ZNF564_ENST00000339282_chr19_12639510_-_1884nt ATGGGTCAGTGGATCGTGTATCCCCTTTGTTCCCCAGGTGACAGCGGGAAGGTGACCACAGTCGTAGCCACTCTAGGCCAAGGCCCAGAG CGCTCCCAAGAAGTGGCTTACACGGACATCAAAGTGATTGGCAATGGCTCATTTGGGGTCGTGTACCAGGCACGGCTGGCAGAGACCAGG GAACTAGTCGCCATCAAGAAGGTTCTCCAGGACAAGAGGTTCAAGGACTCAGTGGCCTCTGAGGATGTGGCTGTGAACTTCACACTTGAG GAGTGGGCTTTGCTGGATCCTTCCCAGAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCTGTGTAGGAAAAAAA TGGGAAGACCAGAGCATTGAAGATTGGTACAAAAATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCAGTGAAAGTAAAGAA TATGATCAATGTGGAGAAGCCTTCAGTCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGACCATGTGAATGTAGT TTGTGTGGGAAAGTCTTCATGCATCATTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATGACTATCAGGAATAT GGAGAGAAACCATATAAATGTAAGCAGTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAACTCACACTGGTGAG AAACCCTATGCATGTCCGGAATGTGGGAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACACTGGAGATGGACCA TATAAATGTCAGGAATGTGGGAAAGCCTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAGAGAAACCCTATGAA TGTCAGGAATGTGCAAAAGCTTTCATTTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGACCTTATAAATGTCAG GAATGTGGAAAAGCCTTTGACCGCCCCAGTTTATTTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATGAATGTAAACAGTGT GGGAAGGCCTTCATTTCTTTCACAAATTTTCAAAGTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTAAAGTATGTGGGAGA GCCTTTATTTTTCCCAGTTATGTTCGAAAGCATGAAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAATGTGGTAAAACCTTC AGTTCTTCCAGTAATGTTCGAACACATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGAAAGCCTTCATTTCT CTCCCAAGTGTCCGAAGACACATGATAAAGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCTTTGACTGTCCCAGT TCATTTCAAATACACGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTTCTCTTAAAAGGATT AGAAAACATATGATACTGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTAGTTCTGTCCGAACA CATGAAAGAACTCATACTGGAGAAAAACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCATTAGAATACATGAA AGAACTCATACCGGAGAAAAACCCTATGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAAGACATGAAAGAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GSK3A_ENST00000222330_chr19_42744107_-_ZNF564_ENST00000339282_chr19_12639510_-_3334nt GAGCCGGAGCCCAAGCCAGAGCGGCGCGGCCTGGAAGAGGCCAGGGCCCGGGGGAGGCGGCGGCAGCGGCGGCGGCTGGGGCAGCCCGGG CAGCCCGAGCCCCGCAGCCTGGGCCTGTGCTCGGCGCCATGAGCGGCGGCGGGCCTTCGGGAGGCGGCCCTGGGGGCTCGGGCAGGGCGC GGACTAGCTCGTTCGCGGAGCCCGGCGGCGGAGGCGGAGGAGGCGGCGGCGGCCCCGGAGGCTCGGCCTCCGGCCCAGGCGGCACCGGCG GCGGAAAGGCATCTGTCGGGGCCATGGGTGGGGGCGTCGGGGCCTCGAGCTCCGGGGGTGGACCCGGCGGCAGCGGCGGAGGAGGCAGCG GAGGCCCCGGCGCAGGCACTAGCTTCCCGCCGCCCGGGGTGAAGCTGGGCCGTGACAGCGGGAAGGTGACCACAGTCGTAGCCACTCTAG GCCAAGGCCCAGAGCGCTCCCAAGAAGTGGCTTACACGGACATCAAAGTGATTGGCAATGGCTCATTTGGGGTCGTGTACCAGGCACGGC TGGCAGAGACCAGGGAACTAGTCGCCATCAAGAAGGTTCTCCAGGACAAGAGGTTCAAGGACTCAGTGGCCTCTGAGGATGTGGCTGTGA ACTTCACACTTGAGGAGTGGGCTTTGCTGGATCCTTCCCAGAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCT GTGTAGGAAAAAAATGGGAAGACCAGAGCATTGAAGATTGGTACAAAAATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCA GTGAAAGTAAAGAATATGATCAATGTGGAGAAGCCTTCAGTCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGAC CATGTGAATGTAGTTTGTGTGGGAAAGTCTTCATGCATCATTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATG ACTATCAGGAATATGGAGAGAAACCATATAAATGTAAGCAGTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAA CTCACACTGGTGAGAAACCCTATGCATGTCCGGAATGTGGGAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACA CTGGAGATGGACCATATAAATGTCAGGAATGTGGGAAAGCCTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAG AGAAACCCTATGAATGTCAGGAATGTGCAAAAGCTTTCATTTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGAC CTTATAAATGTCAGGAATGTGGAAAAGCCTTTGACCGCCCCAGTTTATTTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATG AATGTAAACAGTGTGGGAAGGCCTTCATTTCTTTCACAAATTTTCAAAGTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTA AAGTATGTGGGAGAGCCTTTATTTTTCCCAGTTATGTTCGAAAGCATGAAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAAT GTGGTAAAACCTTCAGTTCTTCCAGTAATGTTCGAACACATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGA AAGCCTTCATTTCTCTCCCAAGTGTCCGAAGACACATGATAAAGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCT TTGACTGTCCCAGTTCATTTCAAATACACGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTT CTCTTAAAAGGATTAGAAAACATATGATACTGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTA GTTCTGTCCGAACACATGAAAGAACTCATACTGGAGAAAAACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCA TTAGAATACATGAAAGAACTCATACCGGAGAAAAACCCTATGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAA GACATGAAAGAGCTCATAATGGAGATAAACCTTACGTAAAGAATGTGGGAAAGCTTTCATTTATCACACAACCTTCGAATACCTGTGAAA ATGAATAGTGGAGGACAGGTCTACAAGTATCTACATATCTAAAGAATATGGAAAGTCTTCAGTTTGCTTTCTGGGTTTCAGACTTGTTTG GGAGCTCACCCCTTTCTCCTGTTTCTCACTTTTGGAATAGGAATCTCTATCCTGTGCCTGTCTCATATTTTGGAAATACATGACTAGTTT GGTTTTCACCGGTTCGGAGCTGAAGAAGAATTTTGCCTCAGCATGAATTGAGTCTCATCCATATCTGAGTGATGTGATATTGAGATGACA CTTTGGAGTTTGAGTTTAAACATTAGGCTTCATGCTGGAATTAACTGAGACTTTTGAGGCCTTTGGGATGAGATGAATATATTTTACATG TGATGACATGGATTTTGGGGGCCAGAGGTGTAATGTTTTGGCTGAGTGTATGCCACCTCAGATTCATATGTTGAAACCTTACCCCCGTGC CCCCCCTCTCCCCCACAATGTGATGGTATTTGGAGGCCCTGTCTCTGGTGGTTTTTAGGATTGGAGGACATCATGAAGATGGAGGCCTTG TAATTGGGATTAGTTTCCTGATAGGAATCCCTAGAGAGCTAGCTTTGCCCTTCACCATGAGAGGGTGCAGTGAGAAGATAGCTATCTTTG AACCGGGAAGCAGGCCCTTACCAGACATGGACTATGCCAGTGCCTTGATATTGGACTTCCCAGCCTCCCAAACCATGAGAAATAAATGTT TGTTGATTAATTAAGCTTTCCAATTTATGGTATTTTGTTTTAGCAACCCAAGCTAAGACACAATCCAATTTTAAAATGGAGGAAAGGACT TGAATAGACATTTCTCCAAAGAAGATACCCAGATGGCCAATAAGCACGTAACAATGCTCGACATCTTTAGTCATTAGGGAAATACAAATC AAACTCAAGACATACATAGCATCTCATTAGGATTAGTAGTATCAAAGATGGAAAACAAGAAATACTGTCAAGGATGTGGAATGTTGGAGA ACATTGTGCACTATCACTGGGAATGTACAGTGGTATAAGCCTGCTGAAAACAGTATGGCAGATCCCCAGATTAAAATATAGAAATAACAT >In-frame_GSK3A_ENST00000398249_chr19_42744107_-_ZNF564_ENST00000339282_chr19_12639510_-_4674nt ATGTTGCTATTCATTATAATATTGGATCAGAGGTCACAGTCGCTTGCAAATGGGGATCTAGGGTTATTGTCTCCTAAGAGAACAAGAATA AGACCAACCCCGAAAAAGAGGGATCTGCATTCCCTGTCCTTCAGAAGATGGGGATTTGGAGCGAATATCACTTAGAAGCAGGGCTTTGAG GTTACTGTGTTTTGTCCCCAAAGAATAGGGCCAGGCTTTCCAAACCTGGTACTCAGATCATCTTCCCTATTAAAACCAAGACCTGGCATC ATTACCCACCCTAAATCTTGTTGAGCTGTACTGCCAATGGTGAGAATTAATAGTTACTGCCTTTTAGATATAAAGACATTGGGAGTCAGC ATATCCTTCAAACCAAGTCCATAGTCCATGTTTTAAAATACATGGCTTGGTGTGTCTCCTTTAACAAAAATGGAATGGAGCAGGGTAGGT CACAGTTTCCTACAGAATATGGATCTAAGGTTATACTTTTTTAATAATTGTTCTAAGGTATGGTGTCATTGGCTCTGAAAAAAAAAAGTG ATGTAGGGTTATCTCCCTCTGAAAGAACTTGTCACTGGCCCCTCAAAATGGATTTGGTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCC AGCACTTTGGGAGGCTGAGGTGGGCGGATCACCTGCGGTCAGGAGTTCGAGACCAGCCTGGCCAACTGGTGGAACCCTGTCTCTACTAAA AATATAAAAAATTAGCTGGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGCAG GCGGAGGTTGCAGTGAGTCGAGATCGTGCCACTGCACTCCAGCTGGGCAACGAGAGCGAAACTGTGTCTCAAAAAAAAAAACAAAAAAAT GGATTTGGTTCATCAGTTACTCAAAGGGGTCACTATCCTCTAAGAATGGCACCAAGGTTTGCCACCATTTGAATAATGGGAATTGGGAAT TATAGCTTTCCTTCAAAGGACTGAGGCTGGAATAGCTCCTTGATAATAAAGGTCAGGTTCATCATTATCATAATTTGGTGCTTGTCCATT AGGGACCACCCACATATAGTGAGGGGTCTGGGTCTCTGGACCACTCAGATGAAGAGGTCAGGTCAGTGTTTTTTTCTAACCTCAAAGTAC CAAAAAGTGAGGGTCAGGGCACTGGCACTTATAGCAGGAGAGGACATTCATTTCTGTCACCAAGAACCAGTAAAGTTACCAGCTCTACAG GGGAGGACTTAGAGGTCAGTATCCTCTAGGCTGTGAGAGAGGTTAGTGCTTTCCTAAAGTAGGAGTACCTCAGGGTTACTGCTCCCTGAA GTGGAAGAGGCTCGGTCAAGCTTTCTCCAAATAGGAGGGGCCAGAGGGCAGTAGATCCAGAGTAGATGGAGTCAACATCTGATGTCTCCC AGTACCAAGATGGACCAGTGATCTGTTGCTTCCTAGAAGTAGAAATTTGGGGTTGCCAACCCTTGAAGCAGAGAGATTTAGGTATCAATA TCCTCCTATGTGGAGGGGAGCAGGACTTAAGATTCCCAGAAAGGAAGAGGGGAAAAGTCACTGGGAAGGTCCCAGCATCCACCTTTCCTC AAAGAGGAGGAGGGGACAAAGAGGTCCCCAACGAGCTTCCTGCAGAGATTTCCCTTCCTCCCACAGCCCCAGGATAGGGTGATGCGCAGG CAGGATGGGTCAGTGGATCGTGTATCCCCTTTGTTCCCCAGGTGACAGCGGGAAGGTGACCACAGTCGTAGCCACTCTAGGCCAAGGCCC AGAGCGCTCCCAAGAAGTGGCTTACACGGACATCAAAGTGATTGGCAATGGCTCATTTGGGGTCGTGTACCAGGCACGGCTGGCAGAGAC CAGGGAACTAGTCGCCATCAAGAAGGTTCTCCAGGACAAGAGGTTCAAGGACTCAGTGGCCTCTGAGGATGTGGCTGTGAACTTCACACT TGAGGAGTGGGCTTTGCTGGATCCTTCCCAGAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCTGTGTAGGAAA AAAATGGGAAGACCAGAGCATTGAAGATTGGTACAAAAATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCAGTGAAAGTAA AGAATATGATCAATGTGGAGAAGCCTTCAGTCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGACCATGTGAATG TAGTTTGTGTGGGAAAGTCTTCATGCATCATTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATGACTATCAGGA ATATGGAGAGAAACCATATAAATGTAAGCAGTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAACTCACACTGG TGAGAAACCCTATGCATGTCCGGAATGTGGGAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACACTGGAGATGG ACCATATAAATGTCAGGAATGTGGGAAAGCCTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAGAGAAACCCTA TGAATGTCAGGAATGTGCAAAAGCTTTCATTTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGACCTTATAAATG TCAGGAATGTGGAAAAGCCTTTGACCGCCCCAGTTTATTTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATGAATGTAAACA GTGTGGGAAGGCCTTCATTTCTTTCACAAATTTTCAAAGTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTAAAGTATGTGG GAGAGCCTTTATTTTTCCCAGTTATGTTCGAAAGCATGAAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAATGTGGTAAAAC CTTCAGTTCTTCCAGTAATGTTCGAACACATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGAAAGCCTTCAT TTCTCTCCCAAGTGTCCGAAGACACATGATAAAGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCTTTGACTGTCC CAGTTCATTTCAAATACACGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTTCTCTTAAAAG GATTAGAAAACATATGATACTGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTAGTTCTGTCCG AACACATGAAAGAACTCATACTGGAGAAAAACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCATTAGAATACA TGAAAGAACTCATACCGGAGAAAAACCCTATGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAAGACATGAAAG AGCTCATAATGGAGATAAACCTTACGTAAAGAATGTGGGAAAGCTTTCATTTATCACACAACCTTCGAATACCTGTGAAAATGAATAGTG GAGGACAGGTCTACAAGTATCTACATATCTAAAGAATATGGAAAGTCTTCAGTTTGCTTTCTGGGTTTCAGACTTGTTTGGGAGCTCACC CCTTTCTCCTGTTTCTCACTTTTGGAATAGGAATCTCTATCCTGTGCCTGTCTCATATTTTGGAAATACATGACTAGTTTGGTTTTCACC GGTTCGGAGCTGAAGAAGAATTTTGCCTCAGCATGAATTGAGTCTCATCCATATCTGAGTGATGTGATATTGAGATGACACTTTGGAGTT TGAGTTTAAACATTAGGCTTCATGCTGGAATTAACTGAGACTTTTGAGGCCTTTGGGATGAGATGAATATATTTTACATGTGATGACATG GATTTTGGGGGCCAGAGGTGTAATGTTTTGGCTGAGTGTATGCCACCTCAGATTCATATGTTGAAACCTTACCCCCGTGCCCCCCCTCTC CCCCACAATGTGATGGTATTTGGAGGCCCTGTCTCTGGTGGTTTTTAGGATTGGAGGACATCATGAAGATGGAGGCCTTGTAATTGGGAT TAGTTTCCTGATAGGAATCCCTAGAGAGCTAGCTTTGCCCTTCACCATGAGAGGGTGCAGTGAGAAGATAGCTATCTTTGAACCGGGAAG CAGGCCCTTACCAGACATGGACTATGCCAGTGCCTTGATATTGGACTTCCCAGCCTCCCAAACCATGAGAAATAAATGTTTGTTGATTAA TTAAGCTTTCCAATTTATGGTATTTTGTTTTAGCAACCCAAGCTAAGACACAATCCAATTTTAAAATGGAGGAAAGGACTTGAATAGACA TTTCTCCAAAGAAGATACCCAGATGGCCAATAAGCACGTAACAATGCTCGACATCTTTAGTCATTAGGGAAATACAAATCAAACTCAAGA CATACATAGCATCTCATTAGGATTAGTAGTATCAAAGATGGAAAACAAGAAATACTGTCAAGGATGTGGAATGTTGGAGAACATTGTGCA |
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FusionGenePPI for GSK3A_ZNF564 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GSK3A | AR, MYC, AKT1, AXIN1, YWHAG, HDAC6, EBNA1BP2, GLI3, CREB1, MAPT, PRKACA, PRKDC, HSP90AA1, PRKCA, PRKCB, PRKCG, PRKCH, PRKCD, DEAF1, SPICE1, MAP3K11, NBR1, VTA1, GSKIP, SPG21, ARHGEF11, KRBA1, FAM193B, PSMD1, AXIN2, PPP1R2, FRAT1, AKAP9, ZDHHC17, TRAK2, FCGR2B, PPP3CC, RCAN2, RICTOR, CTNNB1, RAE1, AIM1, CTNNA1, MDN1, POLR3B, FOXM1, PPP1CA, PPP1CB, PPP1CC, PPP3CB, RCAN1, SAMHD1, FBXO42, SRBD1, ARSG, BCL2L1, TRIM25 | ZNF564 | ALAS1, TRIM23, MAGEA1, MDFI, MEOX2, REL, TADA2A, TRAF1, PNMA1, CALCOCO2, CCDC85B, MID2, CCNDBP1, LDOC1, RPGRIP1, GOPC, CCDC136, TRIM41, KRT40, SPERT, KRTAP10-7, KRTAP10-9, KRTAP10-3, GPR156, PPP1R16B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSK3A_ZNF564 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GSK3A_ZNF564 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GSK3A | C0005586 | Bipolar Disorder | 1 | CTD_human |
| Hgene | GSK3A | C0011581 | Depressive disorder | 1 | CTD_human |
| Hgene | GSK3A | C0036341 | Schizophrenia | 1 | CTD_human |
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