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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 155

FusionGeneSummary for ABCC3_XYLT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC3_XYLT2
Fusion gene ID: 155
HgeneTgene
Gene symbol

ABCC3

XYLT2

Gene ID

8714

64132

Gene nameATP binding cassette subfamily C member 3xylosyltransferase 2
SynonymsABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2PXYLT2|SOS|XT-II|XT2|xylT-II
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrugxylosyltransferase 2UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferasepeptide O-xylosyltransferase 1protein xylosyltransferase 2xylosyltransferase II
Modification date2018052320180519
UniProtAcc

O15438

Q9H1B5

Ensembl transtripts involved in fusion geneENST00000285238, ENST00000515707, 
ENST00000427699, ENST00000510891, 
ENST00000017003, ENST00000507602, 
Fusion gene scores* DoF score8 X 6 X 4=1924 X 2 X 4=32
# samples 104
** MAII scorelog2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABCC3 [Title/Abstract] AND XYLT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-HU-A4GH-01AABCC3chr17

48755580

+XYLT2chr17

48435568

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000285238ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
5CDS-intronENST00000285238ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-3CDSENST00000515707ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-intronENST00000515707ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-3CDSENST00000427699ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-intronENST00000427699ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-3CDSENST00000510891ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-intronENST00000510891ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+

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FusionProtFeatures for ABCC3_XYLT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC3

O15438

XYLT2

Q9H1B5

Catalyzes the first step in the biosynthesis ofchondroitin sulfate, heparan sulfate and dermatan sulfateproteoglycans, such as DCN. Transfers D-xylose from UDP-D-xyloseto specific serine residues of the core protein.{ECO:0000269|PubMed:17189265, ECO:0000269|PubMed:26027496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531311_59412351528DomainABC transmembrane type-1 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531629_85112351528DomainABC transporter 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531661_66812351528Nucleotide bindingATP 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311043_108512351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311107_110712351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311129_119912351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531121_13212351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311221_122212351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531154_17112351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531193_30212351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311_3212351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531324_34912351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531371_42612351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531448_45012351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531472_53312351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253154_7312351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531555_57612351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531598_96312351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253195_9912351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531985_102112351528Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531100_12012351528TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311022_104212351528TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311086_110612351528TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311108_112812351528TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311200_122012351528TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531133_15312351528TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531172_19212351528TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531303_32312351528TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253133_5312351528TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531350_37012351528TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531427_44712351528TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531451_47112351528TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531534_55412351528TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531577_59712351528TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253174_9412351528TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531964_98412351528TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311291_152312351528DomainABC transporter 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531971_125212351528DomainABC transmembrane type-1 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121291_1523-27573DomainABC transporter 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112311_594-27573DomainABC transmembrane type-1 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112629_851-27573DomainABC transporter 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112971_1252-27573DomainABC transmembrane type-1 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311323_133012351528Nucleotide bindingATP 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121323_1330-27573Nucleotide bindingATP 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112661_668-27573Nucleotide bindingATP 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311244_152712351528Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121043_1085-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121107_1107-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121129_1199-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112121_132-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121221_1222-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121244_1527-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112154_171-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112193_302-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121_32-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112324_349-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112371_426-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112448_450-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112472_533-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11254_73-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112555_576-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112598_963-27573Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11295_99-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112985_1021-27573Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311223_124312351528TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112100_120-27573TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121022_1042-27573TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121086_1106-27573TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121108_1128-27573TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121200_1220-27573TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121223_1243-27573TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112133_153-27573TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112172_192-27573TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112303_323-27573TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11233_53-27573TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112350_370-27573TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112427_447-27573TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112451_471-27573TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112534_554-27573TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112577_597-27573TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11274_94-27573TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112964_984-27573TransmembraneHelical%3B Name%3D12
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003+811296_298647866RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003+811400_401647866RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003+811504_505647866RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003+8111_15647866Topological domainCytoplasmic
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003+81137_865647866Topological domainLumenal
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003+81116_36647866TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for ABCC3_XYLT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ABCC3_ENST00000285238_chr17_48755580_+_XYLT2_ENST00000017003_chr17_48435568_+_1454aa
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFY
SFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARH
KASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGP
SVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIH
SGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTH
GISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANV
WLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDF
EIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVGTDWDPKERLFRNFGGLLGPLDEP
VAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDAS
WLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWSSLSPDPK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ABCC3_ENST00000285238_chr17_48755580_+_XYLT2_ENST00000017003_chr17_48435568_+_4362nt
ATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCTGTGCACACAGAAAACCCGGACCTCACTCCC
TGCTTCCAGAACTCCCTGCTGGCCTGGGTGCCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGT
CGTGGCTACATCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTGTGGTGCGTCTCCTGGGCGGACCTTTTTTAC
TCCTTCCATGGCCTGGTCCATGGCCGGGCCCCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACC
CTGCTGATACAGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTCTGGTTCCTGTGTGTGGTCTGCGCCATCGTC
CCATTCCGCTCCAAGATCCTTTTAGCCAAGGCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTG
GTACTCTCTGCCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAGAATGTCGACCCTAACCCCTACCCTGAGACC
AGCGCTGGCTTTCTCTCCCGCCTGTTTTTCTGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTC
TGGTCCCTAAAGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGGAGGAAGCAGGAAAAGCAGACGGCACGACAC
AAGGCTTCAGCAGCACCTGGGAAAAATGCCTCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTG
AAGGCCCTGCTGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATCCAGGACCTGCTCTCCTTCATCAATCCACAG
CTGCTCAGCATCCTGATCAGGTTTATCTCCAACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCC
ATGATGCAGTCGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAGTTTCGTACTGGGATCATGGGTGTCATCTAC
AGGAAGGCTCTGGTTATCACCAACTCAGTCAAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTC
ATGGACCTTGCCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCGATCTACTTCCTCTGGCAGAACCTAGGTCCC
TCTGTCCTGGCTGGAGTCGCTTTCATGGTCTTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAA
ATGAAATTGAAGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTGCTGAAGCTGTACGCCTGGGAGCCCAGCTTC
CTGAAGCAGGTGGAGGGCATCAGGCAGGGTGAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATG
TGCAGCCCCTTCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAACAATGTGCTGGACGCCGAGAAGGCCTTTGTG
TCTGTGTCCTTGTTTAATATCTTAAGACTTCCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAA
CGGATCCAGCAATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACCATCTCCCCAGGCTATGCCATCACCATACAC
AGTGGCACCTTCACCTGGGCCCAGGACCTGCCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTG
GGGCCTGTGGGCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAGCTAGAAGGCAAAGTGCACATGAAGGGCTCC
GTGGCCTATGTGCCCCAGCAGGCATGGATCCAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTAC
CAGCAGACTCTGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGATCAGACAGAGATTGGAGAGAAGGGCATTAAC
CTGTCTGGGGGCCAGCGGCAGCGGGTCAGTCTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCG
GTGGACTCTCATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTGGCAGGCAAGACGCGAGTGCTGGTGACGCAC
GGCATTAGCTTCCTGCCCCAGACAGACTTCATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAG
CGCAACGGCTCCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCACCTGGAGGACAGCTGGACCGCGTTGGAAGGT
GCAGAGGATAAGGAGGCACTGCTGATTGAAGACACACTCAGCAACCACACGGATCTGACAGACAATGATCCAGTCACCTATGTGGTCCAG
AAGCAGTTTATGAGACAGCTGAGTGCCCTGTCCTCAGATGGGGAGGGACAGGGTCGGCCTGTACCCCGGAGGCACCTGGGTCCATCAGAG
AAGGTGCAGGTGACAGAGGCGAAGGCAGATGGGGCACTGACCCAGGAGGAGAAAGCAGCCATTGGCACTGTGGAGCTCAGTGTGTTCTGG
GATTATGCCAAGGCCGTGGGGCTCTGTACCACGCTGGCCATCTGTCTCCTGTATGTGGGTCAAAGTGCGGCTGCCATTGGAGCCAATGTG
TGGCTCAGTGCCTGGACAAATGATGCCATGGCAGACAGTAGACAGAACAACACTTCCCTGAGGCTGGGCGTCTATGCTGCTTTAGGAATT
CTGCAAGGGTTCTTGGTGATGCTGGCAGCCATGGCCATGGCAGCGGGTGGCATCCAGGCTGCCCGTGTGTTGCACCAGGCACTGCTGCAC
AACAAGATACGCTCGCCACAGTCCTTCTTTGACACCACACCATCAGGCCGCATCCTGAACTGCTTCTCCAAGGACATCTATGTCGTTGAT
GAGGTTCTGGCCCCTGTCATCCTCATGCTGCTCAATTCCTTCTTCAACGCCATCTCCACTCTTGTGGTCATCATGGCCAGCACGCCGCTC
TTCACTGTGGTCATCCTGCCCCTGGCTGTGCTCTACACCTTAGTGCAGCGCTTCTATGCAGCCACATCACGGCAACTGAAGCGGCTGGAA
TCAGTCAGCCGCTCACCTATCTACTCCCACTTTTCGGAGACAGTGACTGGTGCCAGTGTCATCCGGGCCTACAACCGCAGCCGGGATTTT
GAGATCATCAGTGATACTAAGGTGGATGCCAACCAGAGAAGCTGCTACCCCTACATCATCTCCAACCGGTGGCTGAGCATCGGAGTGGAG
TTCGTGGGGAACTGCGTGGTGCTCTTTGCTGCACTATTTGCCGTCATCGGGAGGAGCAGCCTGAACCCGGGGCTGGTGGGCCTTTCTGTG
TCCTACTCCTTGCAGGTTGGCACTGATTGGGACCCCAAAGAGCGTCTTTTCCGGAACTTTGGGGGGTTACTGGGGCCGCTGGACGAGCCT
GTGGCCGTGCAGCGCTGGGCCCGGGGCCCCAACCTCACAGCCACAGTGGTCTGGATCGACCCAACCTATGTGGTGGCCACATCTTATGAC
ATCACAGTAGATACGGAGACTGAGGTCACGCAATACAAGCCCCCACTGAGCCGGCCCCTGCGGCCAGGGCCCTGGACTGTTCGACTCCTT
CAGTTCTGGGAACCGCTGGGTGAGACCCGCTTCCTTGTGCTGCCCTTGACCTTCAACCGCAAACTACCTCTCAGGAAAGATGATGCCAGC
TGGCTGCACGCAGGGCCACCCCACAACGAGTACATGGAGCAGAGTTTCCAGGGCCTGAGTAGCATCCTGAACCTGCCTCAGCCGGAGCTC
GCGGAGGAGGCTGCCCAGCGGCACACACAGCTCACAGGCCCTGCGCTCGAGGCCTGGACAGACAGGGAACTGAGCAGCTTCTGGTCCGTG
GCTGGACTGTGTGCCATAGGCCCCTCTCCCTGCCCCTCCCTGGAGCCCTGCAGACTGACCAGCTGGAGCTCTCTGTCCCCCGACCCCAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ABCC3_ENST00000285238_chr17_48755580_+_XYLT2_ENST00000017003_chr17_48435568_+_5302nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCTGTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGA
ACTCCCTGCTGGCCTGGGTGCCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGTCGTGGCTACA
TCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTGTGGTGCGTCTCCTGGGCGGACCTTTTTTACTCCTTCCATG
GCCTGGTCCATGGCCGGGCCCCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACCCTGCTGATAC
AGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTCTGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCT
CCAAGATCCTTTTAGCCAAGGCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTGGTACTCTCTG
CCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAGAATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCT
TTCTCTCCCGCCTGTTTTTCTGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTCTGGTCCCTAA
AGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGGAGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAG
CAGCACCTGGGAAAAATGCCTCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTGAAGGCCCTGC
TGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATCCAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCA
TCCTGATCAGGTTTATCTCCAACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCCATGATGCAGT
CGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAGTTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTC
TGGTTATCACCAACTCAGTCAAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTCATGGACCTTG
CCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCGATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGG
CTGGAGTCGCTTTCATGGTCTTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAAATGAAATTGA
AGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTGCTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGG
TGGAGGGCATCAGGCAGGGTGAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATGTGCAGCCCCT
TCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAACAATGTGCTGGACGCCGAGAAGGCCTTTGTGTCTGTGTCCT
TGTTTAATATCTTAAGACTTCCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAACGGATCCAGC
AATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACCATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCT
TCACCTGGGCCCAGGACCTGCCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTGGGGCCTGTGG
GCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAGCTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATG
TGCCCCAGCAGGCATGGATCCAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTACCAGCAGACTC
TGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGATCAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGG
GCCAGCGGCAGCGGGTCAGTCTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCGGTGGACTCTC
ATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTGGCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCT
TCCTGCCCCAGACAGACTTCATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAGCGCAACGGCT
CCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCACCTGGAGGACAGCTGGACCGCGTTGGAAGGTGCAGAGGATA
AGGAGGCACTGCTGATTGAAGACACACTCAGCAACCACACGGATCTGACAGACAATGATCCAGTCACCTATGTGGTCCAGAAGCAGTTTA
TGAGACAGCTGAGTGCCCTGTCCTCAGATGGGGAGGGACAGGGTCGGCCTGTACCCCGGAGGCACCTGGGTCCATCAGAGAAGGTGCAGG
TGACAGAGGCGAAGGCAGATGGGGCACTGACCCAGGAGGAGAAAGCAGCCATTGGCACTGTGGAGCTCAGTGTGTTCTGGGATTATGCCA
AGGCCGTGGGGCTCTGTACCACGCTGGCCATCTGTCTCCTGTATGTGGGTCAAAGTGCGGCTGCCATTGGAGCCAATGTGTGGCTCAGTG
CCTGGACAAATGATGCCATGGCAGACAGTAGACAGAACAACACTTCCCTGAGGCTGGGCGTCTATGCTGCTTTAGGAATTCTGCAAGGGT
TCTTGGTGATGCTGGCAGCCATGGCCATGGCAGCGGGTGGCATCCAGGCTGCCCGTGTGTTGCACCAGGCACTGCTGCACAACAAGATAC
GCTCGCCACAGTCCTTCTTTGACACCACACCATCAGGCCGCATCCTGAACTGCTTCTCCAAGGACATCTATGTCGTTGATGAGGTTCTGG
CCCCTGTCATCCTCATGCTGCTCAATTCCTTCTTCAACGCCATCTCCACTCTTGTGGTCATCATGGCCAGCACGCCGCTCTTCACTGTGG
TCATCCTGCCCCTGGCTGTGCTCTACACCTTAGTGCAGCGCTTCTATGCAGCCACATCACGGCAACTGAAGCGGCTGGAATCAGTCAGCC
GCTCACCTATCTACTCCCACTTTTCGGAGACAGTGACTGGTGCCAGTGTCATCCGGGCCTACAACCGCAGCCGGGATTTTGAGATCATCA
GTGATACTAAGGTGGATGCCAACCAGAGAAGCTGCTACCCCTACATCATCTCCAACCGGTGGCTGAGCATCGGAGTGGAGTTCGTGGGGA
ACTGCGTGGTGCTCTTTGCTGCACTATTTGCCGTCATCGGGAGGAGCAGCCTGAACCCGGGGCTGGTGGGCCTTTCTGTGTCCTACTCCT
TGCAGGTTGGCACTGATTGGGACCCCAAAGAGCGTCTTTTCCGGAACTTTGGGGGGTTACTGGGGCCGCTGGACGAGCCTGTGGCCGTGC
AGCGCTGGGCCCGGGGCCCCAACCTCACAGCCACAGTGGTCTGGATCGACCCAACCTATGTGGTGGCCACATCTTATGACATCACAGTAG
ATACGGAGACTGAGGTCACGCAATACAAGCCCCCACTGAGCCGGCCCCTGCGGCCAGGGCCCTGGACTGTTCGACTCCTTCAGTTCTGGG
AACCGCTGGGTGAGACCCGCTTCCTTGTGCTGCCCTTGACCTTCAACCGCAAACTACCTCTCAGGAAAGATGATGCCAGCTGGCTGCACG
CAGGGCCACCCCACAACGAGTACATGGAGCAGAGTTTCCAGGGCCTGAGTAGCATCCTGAACCTGCCTCAGCCGGAGCTCGCGGAGGAGG
CTGCCCAGCGGCACACACAGCTCACAGGCCCTGCGCTCGAGGCCTGGACAGACAGGGAACTGAGCAGCTTCTGGTCCGTGGCTGGACTGT
GTGCCATAGGCCCCTCTCCCTGCCCCTCCCTGGAGCCCTGCAGACTGACCAGCTGGAGCTCTCTGTCCCCCGACCCCAAATCAGAGCTGG
GGCCTGTCAAAGCAGACGGGCGACTCAGGTAGCAGGGCCCCAGCCAGTACCCGTGGAGGACCCGGGAAATTGCACCTTACAGACAGTGGA
GGGGTGTCCCCTCCCACAGGCAAGAACCAGAGGCCCAGGCTGCACACCCATTTCAGCCATCAAGAACCCACACAGACGGCAGGGAAGGTG
GACACAGTATGAACTACTGCTGATGTCTCTGTTGGGGATCAGAGGGCTGGCGGGAACGCGAGAAGGGCACCAGCAGCATTCCACACCCAG
CTCTTCCTCACCTTCCTGTCTAGTTTGAATTTCTTTTTTTTCTTTTTTTTTTTTTTTTTTTAATTTAAAAAGGAAAATGGGTGGTTGGGA
GAGAAACTAGAACAGAAGATGTGCAATAGGGCTCAGAGCAGCCCCAGGAAGTGGGCCATGTCTGTGGGGAGCAGGGGCTTGCTGAGCCCA
CCTGCTATTGTTCTGCACGAGGCTGGGCCTGCCTCACTCTCCAGGGCCTCATGCCCCATTCTGGGCCTGTGGTGCTCGTGGCTGAGGCTC
CACAGGGCTGCAAGTGCCCTGCCAGGCTCTAAGGCCCGAAGAACAGGTGATATCGGGGGCGCTGCAGAGCTGGGCTCTAGCAGGACAGTT
CTTTTGTAGCCAGGGGACCCTAGAAGTGGGGTGGGGCGGCTCCAGGGCTTTCCAGCATACCCTGCCCCTGGATGGGAAAGGCAGGGTCAG
GGCCCACTGAGACCCATGCAGAGTTTCCAGGTGTGCACTGGAAGTGAGGTCACATGAGCAGCGTGGGAAGAAGACTCTGTCAAGACTCTC


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FusionGenePPI for ABCC3_XYLT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABCC3MLH1, ATP9A, CANX, IDH3A, VCP, EEF2, VDAC1, VDAC2, VDAC3XYLT2TAZ, IDS, POMK, CAMK1D, B4GALT3, FAM134C, GPC1, UST, CLEC2D, SCGB2A2, LYPD4, LPAR1, RFX3, HDAC1, RTCB, MTA2, PTOV1, TBC1D32, DDX1, RFX1, CDK20, TAF6L, FOXJ1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABCC3_XYLT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABCC3_XYLT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC3C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC3C0008370Cholestasis1CTD_human
HgeneABCC3C0009404Colorectal Neoplasms1CTD_human
TgeneXYLT2C0033847Pseudoxanthoma Elasticum1CTD_human;UNIPROT