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Fusion gene ID: 15460 |
FusionGeneSummary for GRK5_GRK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRK5_GRK5 | Fusion gene ID: 15460 | Hgene | Tgene | Gene symbol | GRK5 | GRK5 | Gene ID | 2869 | 2869 |
| Gene name | G protein-coupled receptor kinase 5 | G protein-coupled receptor kinase 5 | |
| Synonyms | GPRK5 | GPRK5 | |
| Cytomap | 10q26.11 | 10q26.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | G protein-coupled receptor kinase 5FP2025g protein-coupled receptor kinase GRK5 | G protein-coupled receptor kinase 5FP2025g protein-coupled receptor kinase GRK5 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P34947 | P34947 | |
| Ensembl transtripts involved in fusion gene | ENST00000392870, ENST00000369108, ENST00000473264, | ENST00000392870, ENST00000369108, ENST00000473264, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 4 X 5 X 2=40 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GRK5 [Title/Abstract] AND GRK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRK5 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
| Hgene | GRK5 | GO:0043066 | negative regulation of apoptotic process | 20124405 |
| Hgene | GRK5 | GO:0046777 | protein autophosphorylation | 14976207 |
| Tgene | GRK5 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
| Tgene | GRK5 | GO:0043066 | negative regulation of apoptotic process | 20124405 |
| Tgene | GRK5 | GO:0046777 | protein autophosphorylation | 14976207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CV364610 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + | ||
| ChiTaRS3.1 | BI037433 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000392870 | ENST00000392870 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000392870 | ENST00000369108 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000392870 | ENST00000473264 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000369108 | ENST00000392870 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000369108 | ENST00000369108 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000369108 | ENST00000473264 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000473264 | ENST00000392870 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000473264 | ENST00000369108 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000473264 | ENST00000473264 | GRK5 | chr10 | 121007774 | - | GRK5 | chr10 | 121006210 | + |
| intron-intron | ENST00000392870 | ENST00000392870 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000392870 | ENST00000369108 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000392870 | ENST00000473264 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000369108 | ENST00000392870 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000369108 | ENST00000369108 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000369108 | ENST00000473264 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000473264 | ENST00000392870 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000473264 | ENST00000369108 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
| intron-intron | ENST00000473264 | ENST00000473264 | GRK5 | chr10 | 121115873 | - | GRK5 | chr10 | 121116100 | + |
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FusionProtFeatures for GRK5_GRK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRK5 | GRK5 |
| Serine/threonine kinase that phosphorylatespreferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiatesbeta-arrestin-mediated receptor desensitization, internalization,and signaling events leading to their down-regulation.Phosphorylates a variety of GPCRs, including adrenergic receptors,muscarinic acetylcholine receptors (more specifically Gi-coupledM2/M4 subtypes), dopamine receptors and opioid receptors. Inaddition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1.Phosphorylation of ARRB1 by GRK5 inhibits G-protein independentMAPK1/MAPK3 signaling downstream of 5HT4-receptors.Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2(MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucialtumor suppressor, inhibits TP53/p53-mediated apoptosis.Phosphorylation of ST13 regulates internalization of the chemokinereceptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).{ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552,ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405,ECO:0000269|PubMed:21728385}. | Serine/threonine kinase that phosphorylatespreferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiatesbeta-arrestin-mediated receptor desensitization, internalization,and signaling events leading to their down-regulation.Phosphorylates a variety of GPCRs, including adrenergic receptors,muscarinic acetylcholine receptors (more specifically Gi-coupledM2/M4 subtypes), dopamine receptors and opioid receptors. Inaddition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1.Phosphorylation of ARRB1 by GRK5 inhibits G-protein independentMAPK1/MAPK3 signaling downstream of 5HT4-receptors.Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2(MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucialtumor suppressor, inhibits TP53/p53-mediated apoptosis.Phosphorylation of ST13 regulates internalization of the chemokinereceptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).{ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552,ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405,ECO:0000269|PubMed:21728385}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRK5_GRK5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRK5_GRK5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRK5_GRK5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRK5_GRK5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRK5 | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Hgene | GRK5 | C0023895 | Liver diseases | 1 | CTD_human |
| Hgene | GRK5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | GRK5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | GRK5 | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Tgene | GRK5 | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | GRK5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | GRK5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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