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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15429

FusionGeneSummary for GRIK2_MANEA

check button Fusion gene summary
Fusion gene informationFusion gene name: GRIK2_MANEA
Fusion gene ID: 15429
HgeneTgene
Gene symbol

GRIK2

MANEA

Gene ID

2901

79694

Gene nameglutamate ionotropic receptor kainate type subunit 5mannosidase endo-alpha
SynonymsEAA2|GRIK2|GluK5|KA2ENDO|hEndo
Cytomap

19q13.2

6q16.1

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2glycoprotein endo-alpha-1,2-mannosidasealpha 1,2-endomannosidaseendo-alpha mannosidaseendomannosidasemandaselin
Modification date2018052320180519
UniProtAcc

Q13002

Q5SRI9

Ensembl transtripts involved in fusion geneENST00000413795, ENST00000369138, 
ENST00000421544, ENST00000358361, 
ENST00000318991, ENST00000369137, 
ENST00000369134, 		ENST00000369293, 
ENST00000358812, ENST00000474553, 
Fusion gene scores* DoF score7 X 3 X 4=842 X 1 X 2=4
# samples 62
** MAII scorelog2(6/84*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: GRIK2 [Title/Abstract] AND MANEA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A197-06AGRIK2chr6

102134228

+MANEAchr6

96034278

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000413795ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000413795ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000413795ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000369138ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000369138ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000369138ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000421544ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000421544ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000421544ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000358361ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000358361ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000358361ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000318991ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000318991ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000318991ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000369137ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000369137ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000369137ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000369134ENST00000369293GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-5UTRENST00000369134ENST00000358812GRIK2chr6

102134228

+MANEAchr6

96034278

+
5CDS-intronENST00000369134ENST00000474553GRIK2chr6

102134228

+MANEAchr6

96034278

+

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FusionProtFeatures for GRIK2_MANEA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRIK2

Q13002

MANEA

Q5SRI9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRIK2_MANEA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRIK2_MANEA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRIK2SDCBP, PICK1, DLG4, GRIP1, GRID2, DLG1, DLG3, GRIK5, GRIA1, GRIA2, CALCOCO1, TRIM25, PARK2MANEAPRD, AMPH, DNM2, ASGR2, HSD11B1, ANTXR1, PLAUR, SLC39A4, UGT1A10, SIAE, PSG1, OLFM1, CPVL, CNDP1, CD79B, CSGALNACT2, AOC3, TRDN, CLU, GGT7, SLC39A12, TRHDE, SCN3B, TMEM30B, MME


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRIK2_MANEA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGRIK2Q13002DB00849MethylphenobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved
HgeneGRIK2Q13002DB01354HeptabarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved
HgeneGRIK2Q13002DB01355HexobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved
HgeneGRIK2Q13002DB00306TalbutalGlutamate receptor ionotropic, kainate 2small moleculeapproved|illicit
HgeneGRIK2Q13002DB01351AmobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved|illicit
HgeneGRIK2Q13002DB01352AprobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved|illicit
HgeneGRIK2Q13002DB01353ButethalGlutamate receptor ionotropic, kainate 2small moleculeapproved|illicit
HgeneGRIK2Q13002DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved|investigational
HgeneGRIK2Q13002DB00312PentobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved|investigational|vet_approved
HgeneGRIK2Q13002DB00142Glutamic AcidGlutamate receptor ionotropic, kainate 2small moleculeapproved|nutraceutical
HgeneGRIK2Q13002DB00418SecobarbitalGlutamate receptor ionotropic, kainate 2small moleculeapproved|vet_approved
HgeneGRIK2Q13002DB00599ThiopentalGlutamate receptor ionotropic, kainate 2small moleculeapproved|vet_approved
HgeneGRIK2Q13002DB00794PrimidoneGlutamate receptor ionotropic, kainate 2small moleculeapproved|vet_approved

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RelatedDiseases for GRIK2_MANEA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRIK2C0005586Bipolar Disorder3CTD_human;PSYGENET
HgeneGRIK2C0004352Autistic Disorder2CTD_human
HgeneGRIK2C0033953Psychosexual Disorders1CTD_human
HgeneGRIK2C0036341Schizophrenia1CTD_human
HgeneGRIK2C0236969Substance-Related Disorders1CTD_human
HgeneGRIK2C0525045Mood Disorders1PSYGENET
TgeneMANEAC0236736Cocaine-Related Disorders2CTD_human
TgeneMANEAC0032460Polycystic Ovary Syndrome1CTD_human
TgeneMANEAC1456784Paranoia1CTD_human