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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15374

FusionGeneSummary for GRB7_CD300E

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7_CD300E
Fusion gene ID: 15374
HgeneTgene
Gene symbol

GRB7

CD300E

Gene ID

2886

342510

Gene namegrowth factor receptor bound protein 7CD300e molecule
Synonyms-CD300LE|CLM-2|CLM2|CMRF35-A5|IREM-2|IREM2|PIgR-2|PIgR2
Cytomap

17q12

17q25.1

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7CMRF35-like molecule 2CD300 antigen-like family member ECD300e antigenimmune receptor expressed on myeloid cells 2poly-Ig receptor 2polymeric immunoglobulin receptor 2
Modification date2018051920180519
UniProtAcc

Q14451

Q496F6

Ensembl transtripts involved in fusion geneENST00000309156, ENST00000309185, 
ENST00000394211, ENST00000578702, 
ENST00000445327, ENST00000394209, 
ENST00000394204, 
ENST00000392619, 
ENST00000426295, ENST00000328630, 
Fusion gene scores* DoF score11 X 8 X 7=6161 X 1 X 1=1
# samples 131
** MAII scorelog2(13/616*10)=-2.24441872766645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: GRB7 [Title/Abstract] AND CD300E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A9SK-01AGRB7chr17

37901237

+CD300Echr17

72610172

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000309156ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000309156ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000309156ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000309185ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000309185ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000309185ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394211ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394211ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394211ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-
intron-3CDSENST00000578702ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
intron-3CDSENST00000578702ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
intron-3CDSENST00000578702ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000445327ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000445327ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000445327ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394209ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394209ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394209ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394204ENST00000392619GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394204ENST00000426295GRB7chr17

37901237

+CD300Echr17

72610172

-
Frame-shiftENST00000394204ENST00000328630GRB7chr17

37901237

+CD300Echr17

72610172

-

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FusionProtFeatures for GRB7_CD300E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB7

Q14451

CD300E

Q496F6

Probably acts as an activating receptor.{ECO:0000269|PubMed:15557162}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRB7_CD300E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRB7_CD300E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRB7SFN, LY6G6F, ERBB3, KIT, RND1, RET, ERBB2, PTK2, EPHB1, INSR, NPM1, RPS2, ZBTB16, A1BG, ATP5B, CPNE6, PKM, DYNC1I1, AGAP1, GNB2, TMSB4X, PDHB, FLAD1, DOCK7, MSH2, HADHB, TLE1, KMT2B, FGB, PHAX, SETDB1, CALM1, LAX1, TRIM36, KCTD6, OLIG1, ZNHIT1CD300ETMEM67, SPPL2B, PKD2, ATF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRB7_CD300E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRB7_CD300E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB7C1458155Mammary Neoplasms2CTD_human
HgeneGRB7C0001418Adenocarcinoma1CTD_human
HgeneGRB7C0007134Renal Cell Carcinoma1CTD_human
HgeneGRB7C0024121Lung Neoplasms1CTD_human
HgeneGRB7C0033578Prostatic Neoplasms1CTD_human