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Fusion gene ID: 15369 |
FusionGeneSummary for GRB2_TEX14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRB2_TEX14 | Fusion gene ID: 15369 | Hgene | Tgene | Gene symbol | GRB2 | TEX14 | Gene ID | 2885 | 56155 |
| Gene name | growth factor receptor bound protein 2 | testis expressed 14, intercellular bridge forming factor | |
| Synonyms | ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2 | CT113|SPGF23 | |
| Cytomap | 17q25.1 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | growth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ash | inactive serine/threonine-protein kinase TEX14cancer/testis antigen 113protein kinase-like protein SgK307sugen kinase 307testis-expressed protein 14testis-expressed sequence 14 protein | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P62993 | Q8IWB6 | |
| Ensembl transtripts involved in fusion gene | ENST00000392562, ENST00000316804, ENST00000316615, ENST00000392563, ENST00000392564, ENST00000578961, ENST00000462266, | ENST00000389934, ENST00000349033, ENST00000240361, ENST00000584699, | |
| Fusion gene scores | * DoF score | 11 X 4 X 9=396 | 6 X 4 X 4=96 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRB2 [Title/Abstract] AND TEX14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A1HO-01A | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000392562 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392562 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392562 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-intron | ENST00000392562 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-3CDS | ENST00000316804 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-3CDS | ENST00000316804 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-3CDS | ENST00000316804 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-intron | ENST00000316804 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-3CDS | ENST00000316615 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-3CDS | ENST00000316615 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-3CDS | ENST00000316615 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| 5UTR-intron | ENST00000316615 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392563 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392563 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392563 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-intron | ENST00000392563 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392564 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392564 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000392564 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-intron | ENST00000392564 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000578961 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000578961 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000578961 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-intron | ENST00000578961 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000462266 | ENST00000389934 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000462266 | ENST00000349033 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-3CDS | ENST00000462266 | ENST00000240361 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
| intron-intron | ENST00000462266 | ENST00000584699 | GRB2 | chr17 | 73401570 | - | TEX14 | chr17 | 56707915 | - |
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FusionProtFeatures for GRB2_TEX14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRB2 | TEX14 |
| Adapter protein that provides a critical link betweencell surface growth factor receptors and the Ras signalingpathway. Isoform 2 does not bind to phosphorylated epidermalgrowth factor receptor (EGFR) but inhibits EGF-inducedtransactivation of a RAS-responsive element. Isoform 2 acts as adominant negative protein over GRB2 and by suppressingproliferative signals, may trigger active programmed cell death. | Required both for the formation of intercellular bridgesduring meiosis and for kinetochore-microtubule attachment duringmitosis. Intercellular bridges are evolutionarily conservedstructures that connect differentiating germ cells and arerequired for spermatogenesis and male fertility. Acts by promotingthe conversion of midbodies into intercellular bridges via itsinteraction with CEP55: interaction with CEP55 inhibits theinteraction between CEP55 and PDCD6IP/ALIX and TSG101, blockingcell abscission and leading to transform midbodies intointercellular bridges. Also plays a role during mitosis: recruitedto kinetochores by PLK1 during early mitosis and regulates thematuration of the outer kinetochores and microtubule attachment.Has no protein kinase activity in vitro (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRB2_TEX14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRB2_TEX14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GRB2 | CSF1R, PRRC2A, EGFR, ERBB2, ERBB3, ERBB4, MED28, BCR, GAB2, CBL, ETV6, LY6G6F, NEU3, SRC, PDE6G, DOCK1, FASLG, SHC1, SOS1, VAV2, VAV3, RACGAP1, IQGAP1, KRT7, KRT8, KRT17, KRT18, PLEC, EPPK1, BCAR1, WAS, MAP4K1, BLNK, IL2RB, SYN1, PDGFRB, KHDRBS1, PTPN6, PTPN11, SYK, CD22, GAB1, IRS1, TNFRSF1A, PTK2, SH3BP2, CD28, TNK2, KIT, SOCS1, PTPRA, CBLB, EPHA2, AXL, DAG1, MAP2, PLCG1, MST1R, ITGA2B, NCKIPSD, NTRK1, PTPN1, JAK2, GRB2, USP8, CSF3R, HTT, MET, LCP2, SNTA1, ABL1, LAT, FLT4, PIK3R1, FRS2, GAB3, VAV1, SH2B2, SH2B1, PRKAR1A, DCTN1, RET, CRK, PTPN22, JAK1, ARHGAP17, SHB, REPS2, OCRL, PDGFRA, PXN, PAG1, TRAT1, INSR, RAPGEF1, KDR, SELL, ADRB2, EPOR, SYNCRIP, ZAP70, IRS4, MUC1, ITK, LAT2, SH2B3, ANXA2, ARHGAP35, RASA1, PTPN12, CRKL, ADAM15, ADAM10, WASL, EPS15, IL6ST, SH3KBP1, EPHB1, MAP3K1, FLT3, RALGPS1, USP6NL, SPRY2, PTPRE, DNM1, HNRNPC, MAPK9, DRD3, CDKN1B, ALOX5, PIK3C2B, GHR, HCLS1, DTX1, LAX1, SOS2, DRD4, PTK2B, SKAP1, TOM1L1, SHKBP1, FGFR3, INPP5D, MICAL1, PLXNB1, OTUD5, STAMBP, ALK, NPM1, BTK, CSN2, DAB2, EP300, HNRNPK, HSPA5, MAP1A, ATP8, ND4, MYH9, MYH11, NCL, NFYB, PIK3R2, RBBP6, SLC1A2, SPTBN1, SS18, UBA52, UBC, WIPF1, MAP4K3, ASAP2, SYNJ2, DLGAP1, ARHGAP32, HELZ, PDCD6IP, HIPK3, DCTN2, TCERG1, KIF3A, MAP4K5, KIAA1549L, ABI3BP, PTPN23, ASAP1, ERRFI1, WDR44, USP53, RIF1, SH2D4A, GAREM, RBM33, MSI2, WIPF2, SH3D19, NAP1L5, STK32C, MYO18A, A2M, AEBP1, AGT, AHSG, ALAS2, STRADB, AMBP, APCS, APOH, SNRNP200, B2M, GPANK1, BPGM, CLU, DNAJA3, DNAJB11, ESD, FABP1, FHOD1, FN1, GC, H1F0, HP, IK, PBXIP1, POLR2A, PRKAB1, RNF10, TF, TFG, TSC2, ENO1, ITIH4, AP4S1, CUTA, POMP, C21orf58, CD164, C21orf91, CFH, COX6A1, ECHS1, FH, NADK, FTL, PRAP1, GSTK1, TCEAL8, POLR1D, RBP4, SHBG, WDR1, IRF5, PPP3CA, GIT1, CDC42, CASP2, ELAVL1, SYNM, AP2A2, DNM2, NCK1, UBASH3B, CUL3, DCUN1D1, LRRK1, INPPL1, ARAP1, KRT85, HSPA8, HSPG2, KRT86, KRT1, KRT81, KRT35, CAD, KRT10, KRT2, HSPA9, KRT83, CCT8, KRT9, KRT33B, HSP90AA1, DNM3, DYNC1H1, TUBB, KRT34, RPS19, HSPA1B, HSP90AB1, SKAP2, CCT4, EEF1A1P5, KRT6A, KRT14, TUBB4B, TUBA1C, KRT16, TCP1, CCT2, ACTB, FAM175B, CCT3, KRT5, KRT15, CLPX, EEF1G, PSMD11, CALM3, HSPA1L, KRT32, DARS, HSPD1, EEF1D, CNOT1, UBR4, AHNAK, CLTC, KRT36, KRT82, MFAP4, PSTPIP2, PSMC2, PSME1, PSMD14, CD2AP, FUS, BRE, KRT19, CTTN, KRT4, VASP, CCT7, KRT73, HNRNPU, BABAM1, HNRNPD, DRG1, IMPDH2, SERBP1, PIK3CA, TUBA4B, BRCC3, DOK3, HIST4H4, GAPDH, RUVBL1, PSMD13, RPS20, ACTL6A, RARS, CCT5, HSD17B4, TSG101, IRS2, PDE4D, SPRY1, SPRY4, VCAM1, ELMO2, WDR6, WDR77, SNX18, NISCH, YWHAZ, STARD10, YWHAE, SH3PXD2B, DOCK4, PEAK1, PIK3CB, SLC25A5, YWHAB, YWHAQ, PPP2R2A, SIRPA, SYNJ1, FGD6, PIK3AP1, KIRREL, YWHAG, GAREML, AGER, WIPF3, PTPN18, SLC25A13, CYFIP2, ARHGEF7, PPP1CA, CSK, PTPRJ, YWHAH, CSRP1, SH3PXD2A, TTYH2, PIK3R3, FLNA, ARHGAP12, RADIL, SH2D5, FAU, NCKAP1, DIAPH1, HGS, CLASP2, TEC, SLC25A6, HUNK, MLLT4, C1orf27, PPP1CC, HDGFRP3, SLAIN2, EPS15L1, IGF2BP1, PPP5C, GJA9, TAB1, ITGA4, BAG3, CKS2, FTH1, COPB1, PHACTR4, SF3B4, VIM, UBA1, PHC2, KPNA2, CTAGE5, PON2, ARHGEF5, CASC3, MLXIPL, WBP11, YLPM1, SHANK3, NKD2, SLX1A, ACTG1, CBR1, AP2A1, AP2B1, AP2M1, AP2S1, HIST1H3A, SMU1, SNRPD2, CD59, ABL2, AES, EPS8, LMO2, REL, TRIM27, TP53BP2, DDX17, IKZF3, ZBTB7B, ABI3, NUTM2F, DPPA4, HOMEZ, NIF3L1, ARHGAP9, LZTS2, LNX1, C1orf94, PNMA5, PRR22, INCA1, DOK1, FKBP2, FABP5, ITCH, ROS1, HEXB, ACAP1, PLEKHS1, AUNIP, UQCC2, CRBN, LMX1A, MYOZ1, PACRGL, PARD6A, PCDHB5, PPARA, RB1, SOCS4, TMEM128, TSPAN2, VCP, WDFY3, DBN1, E2F2, ARL6IP4, OLIG1, WBSCR27, ZMAT1, CLNK, CEP170, FBF1, MCM2, USP12, GFAP, NEFH, HNRNPA2B1, RPS27A, LGALS3BP, MYL12A, MYL12B, S100A8, S100A9, ESRRB, LIME1, KRAS, LTK, SHC2, SHC4, DUSP13, DUSP8, CYLD, VPS37B, NKX2-5, SPATA2L, MVB12A, ZMYM6, VPS28, DOCK5, THEMIS, RAC1, TRIM25 | TEX14 | CEP55, TEX14, REST |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRB2_TEX14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRB2_TEX14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRB2 | C0036341 | Schizophrenia | 2 | PSYGENET |
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