FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15362

FusionGeneSummary for GRB2_GRB2

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB2_GRB2
Fusion gene ID: 15362
HgeneTgene
Gene symbol

GRB2

GRB2

Gene ID

2885

2885

Gene namegrowth factor receptor bound protein 2growth factor receptor bound protein 2
SynonymsASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ashgrowth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ash
Modification date2018052720180527
UniProtAcc

P62993

P62993

Ensembl transtripts involved in fusion geneENST00000392562, ENST00000316804, 
ENST00000316615, ENST00000392563, 
ENST00000392564, ENST00000578961, 
ENST00000462266, 
ENST00000392562, 
ENST00000316804, ENST00000316615, 
ENST00000392563, ENST00000392564, 
ENST00000578961, ENST00000462266, 
Fusion gene scores* DoF score11 X 4 X 9=3966 X 4 X 4=96
# samples 116
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB2 [Title/Abstract] AND GRB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI940563GRB2chr17

73316469

+GRB2chr17

73316508

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000392562ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392562ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392562ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392562ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392562ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392562ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000392562ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316804ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316804ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316804ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316804ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316804ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316804ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000316804ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316615ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316615ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316615ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316615ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316615ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000316615ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000316615ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392563ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392563ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392563ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392563ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392563ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392563ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000392563ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392564ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392564ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392564ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392564ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392564ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000392564ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000392564ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000578961ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000578961ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000578961ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000578961ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000578961ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000578961ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000578961ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000462266ENST00000392562GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000462266ENST00000316804GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000462266ENST00000316615GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000462266ENST00000392563GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000462266ENST00000392564GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-3CDSENST00000462266ENST00000578961GRB2chr17

73316469

+GRB2chr17

73316508

-
intron-5UTRENST00000462266ENST00000462266GRB2chr17

73316469

+GRB2chr17

73316508

-

Top

FusionProtFeatures for GRB2_GRB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB2

P62993

GRB2

P62993

Adapter protein that provides a critical link betweencell surface growth factor receptors and the Ras signalingpathway. Isoform 2 does not bind to phosphorylated epidermalgrowth factor receptor (EGFR) but inhibits EGF-inducedtransactivation of a RAS-responsive element. Isoform 2 acts as adominant negative protein over GRB2 and by suppressingproliferative signals, may trigger active programmed cell death. Adapter protein that provides a critical link betweencell surface growth factor receptors and the Ras signalingpathway. Isoform 2 does not bind to phosphorylated epidermalgrowth factor receptor (EGFR) but inhibits EGF-inducedtransactivation of a RAS-responsive element. Isoform 2 acts as adominant negative protein over GRB2 and by suppressingproliferative signals, may trigger active programmed cell death.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GRB2_GRB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GRB2_GRB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GRB2_GRB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GRB2_GRB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB2C0036341Schizophrenia2PSYGENET
TgeneGRB2C0036341Schizophrenia2PSYGENET