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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15353

FusionGeneSummary for GRB10_SCIN

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB10_SCIN
Fusion gene ID: 15353
HgeneTgene
Gene symbol

GRB10

SCIN

Gene ID

2887

85477

Gene namegrowth factor receptor bound protein 10scinderin
SynonymsGRB-IR|Grb-10|IRBP|MEG1|RSS-
Cytomap

7p12.1

7p21.3

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1adseverin
Modification date2018052220180519
UniProtAcc

Q13322

Q9Y6U3

Ensembl transtripts involved in fusion geneENST00000398810, ENST00000439599, 
ENST00000398812, ENST00000335866, 
ENST00000402578, ENST00000403097, 
ENST00000406641, ENST00000357271, 
ENST00000407526, ENST00000401949, 
ENST00000402497, ENST00000483819, 
ENST00000297029, ENST00000519209, 
ENST00000445618, ENST00000473722, 
Fusion gene scores* DoF score10 X 6 X 8=4805 X 5 X 4=100
# samples 105
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB10 [Title/Abstract] AND SCIN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB10

GO:0030178

negative regulation of Wnt signaling pathway

17376403

HgeneGRB10

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

15060076


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1557-01AGRB10chr7

50737419

-SCINchr7

12662426

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398810ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000398810ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000398810ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000398810ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
In-frameENST00000439599ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000439599ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000439599ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000439599ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
In-frameENST00000398812ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000398812ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000398812ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000398812ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
Frame-shiftENST00000335866ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000335866ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000335866ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000335866ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
In-frameENST00000402578ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000402578ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000402578ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000402578ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
Frame-shiftENST00000403097ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000403097ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000403097ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000403097ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
Frame-shiftENST00000406641ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000406641ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000406641ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000406641ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
In-frameENST00000357271ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000357271ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000357271ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000357271ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
Frame-shiftENST00000407526ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000407526ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000407526ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000407526ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
Frame-shiftENST00000401949ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000401949ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000401949ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000401949ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
Frame-shiftENST00000402497ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000402497ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-5UTRENST00000402497ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
5CDS-3UTRENST00000402497ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+
intron-3CDSENST00000483819ENST00000297029GRB10chr7

50737419

-SCINchr7

12662426

+
intron-5UTRENST00000483819ENST00000519209GRB10chr7

50737419

-SCINchr7

12662426

+
intron-5UTRENST00000483819ENST00000445618GRB10chr7

50737419

-SCINchr7

12662426

+
intron-3UTRENST00000483819ENST00000473722GRB10chr7

50737419

-SCINchr7

12662426

+

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FusionProtFeatures for GRB10_SCIN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB10

Q13322

SCIN

Q9Y6U3

Ca(2+)-dependent actin filament-severing protein thathas a regulatory function in exocytosis by affecting theorganization of the microfilament network underneath the plasmamembrane (PubMed:8547642, PubMed:26365202). Severing activity isinhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (Bysimilarity). In vitro, also has barbed end capping and nucleatingactivities in the presence of Ca(2+). Required for megakaryocytedifferentiation, maturation, polyploidization and apoptosis withthe release of platelet-like particles (PubMed:11568009). Plays arole in osteoclastogenesis (OCG) and actin cytoskeletalorganization in osteoclasts (By similarity). Regulates chondrocyteproliferation and differentiation (By similarity). Inhibits cellproliferation and tumorigenesis. Signaling is mediated by MAPK,p38 and JNK pathways (PubMed:11568009).{ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9,ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009,ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316364_715222716RegionNote=Ca(2+)-dependent actin binding
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013112_119-25469RegionPolyphosphoinositide binding
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013138_146-25469RegionPolyphosphoinositide binding
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+0131_363-25469RegionActin-severing
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013364_715-25469RegionNote=Ca(2+)-dependent actin binding
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114112_119-25469RegionPolyphosphoinositide binding
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114138_146-25469RegionPolyphosphoinositide binding
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+1141_363-25469RegionActin-severing
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114364_715-25469RegionNote=Ca(2+)-dependent actin binding
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316265_307222716RepeatNote=Gelsolin-like 3
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316398_451222716RepeatNote=Gelsolin-like 4
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316523_564222716RepeatNote=Gelsolin-like 5
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316626_668222716RepeatNote=Gelsolin-like 6
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013148_188-25469RepeatNote=Gelsolin-like 2
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013265_307-25469RepeatNote=Gelsolin-like 3
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+01327_76-25469RepeatNote=Gelsolin-like 1
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013398_451-25469RepeatNote=Gelsolin-like 4
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013523_564-25469RepeatNote=Gelsolin-like 5
TgeneSCINchr7:50737419chr7:12662426ENST00000445618+013626_668-25469RepeatNote=Gelsolin-like 6
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114148_188-25469RepeatNote=Gelsolin-like 2
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114265_307-25469RepeatNote=Gelsolin-like 3
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+11427_76-25469RepeatNote=Gelsolin-like 1
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114398_451-25469RepeatNote=Gelsolin-like 4
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114523_564-25469RepeatNote=Gelsolin-like 5
TgeneSCINchr7:50737419chr7:12662426ENST00000519209+114626_668-25469RepeatNote=Gelsolin-like 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB10chr7:50737419chr7:12662426ENST00000335866-517166_250110537DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000335866-517290_399110537DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000335866-517493_574110537DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000357271-415166_250168549DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000357271-415290_399168549DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000357271-415493_574168549DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000398810-416166_250110537DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000398810-416290_399110537DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000398810-416493_574110537DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000398812-416166_250168595DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000398812-416290_399168595DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000398812-416493_574168595DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000401949-719166_250168595DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000401949-719290_399168595DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000401949-719493_574168595DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000402497-416166_250110537DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000402497-416290_399110537DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000402497-416493_574110537DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000402578-416166_250110537DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000402578-416290_399110537DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000402578-416493_574110537DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000403097-618166_250162589DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000403097-618290_399162589DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000403097-618493_574162589DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000406641-517166_250110537DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000406641-517290_399110537DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000406641-517493_574110537DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000407526-416166_250110537DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000407526-416290_399110537DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000407526-416493_574110537DomainSH2
HgeneGRB10chr7:50737419chr7:12662426ENST00000439599-416166_250162589DomainRas-associating
HgeneGRB10chr7:50737419chr7:12662426ENST00000439599-416290_399162589DomainPH
HgeneGRB10chr7:50737419chr7:12662426ENST00000439599-416493_574162589DomainSH2
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316112_119222716RegionPolyphosphoinositide binding
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316138_146222716RegionPolyphosphoinositide binding
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+3161_363222716RegionActin-severing
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+316148_188222716RepeatNote=Gelsolin-like 2
TgeneSCINchr7:50737419chr7:12662426ENST00000297029+31627_76222716RepeatNote=Gelsolin-like 1


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FusionGeneSequence for GRB10_SCIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GRB10_ENST00000398810_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_604aa
MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGP
GSPPVLTPGSLPPSQAAAKQVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQ
IFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSP
QMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIR
VSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEE
EKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWE

>In-frame_GRB10_ENST00000439599_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_656aa
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGGDDDDII
ADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQV
LPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFY
GGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPT
RLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQ
TSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTP

>In-frame_GRB10_ENST00000398812_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_662aa
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGG
DDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSK
NTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQN
SYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ
APAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLG
GKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG

>In-frame_GRB10_ENST00000402578_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_604aa
MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGP
GSPPVLTPGSLPPSQAAAKQVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQ
IFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSP
QMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIR
VSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEE
EKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWE

>In-frame_GRB10_ENST00000357271_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_662aa
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGG
DDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSK
NTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQN
SYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ
APAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLG
GKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GRB10_ENST00000398810_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_1812nt
ATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGC
CAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTC
GCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCT
GGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGAT
GGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGA
GTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAA
ATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTAT
TCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAG
AGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCG
CAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGAC
CAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGA
GCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGA
GTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGA
GGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCA
AATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAG
GAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCC
CTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAA
ACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAA
CAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCT
TCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCC

>In-frame_GRB10_ENST00000439599_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_1968nt
ATGCAAGCTGCCGGCCCTCTGTTCCGTAGTAAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCC
GCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTG
TACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCT
CGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAA
GACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCG
GGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATA
GCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAAC
CCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGAT
GCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTT
CTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTAT
GTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATG
GTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTAT
GGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTG
ACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTT
CACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACA
CGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTT
TTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCA
AGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAG
ACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAG
ATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAA
GATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCA

>In-frame_GRB10_ENST00000398812_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_1986nt
ATGGCTTTAGCCGGCTGCCCAGATTCCTTTTTGCACCATCCGTACTACCAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCG
GCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAAT
GCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCT
CGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTC
AGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGC
CCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGT
GATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACT
GTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTC
GTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAG
AATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGAT
GGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATG
GCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAAC
TCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAAT
GCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCC
CAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAG
GCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCA
CTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAA
GGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGA
GGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGA
AGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATA
TTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGA
AGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAAG

>In-frame_GRB10_ENST00000402578_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_1812nt
ATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGC
CAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTC
GCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCT
GGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGAT
GGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGA
GTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAA
ATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTAT
TCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAG
AGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCG
CAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGAC
CAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGA
GCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGA
GTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGA
GGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCA
AATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAG
GAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCC
CTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAA
ACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAA
CAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCT
TCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCC

>In-frame_GRB10_ENST00000357271_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_1986nt
ATGGCTTTAGCCGGCTGCCCAGATTCCTTTTTGCACCATCCGTACTACCAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCG
GCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAAT
GCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCT
CGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTC
AGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGC
CCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGT
GATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACT
GTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTC
GTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAG
AATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGAT
GGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATG
GCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAAC
TCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAAT
GCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCC
CAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAG
GCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCA
CTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAA
GGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGA
GGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGA
AGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATA
TTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGA
AGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GRB10_ENST00000398810_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_2985nt
CGCAACTTTGCCTCCCAGGGAACAAACATCCTCCTTCTAAGTGGTAGATGTGGGTGAGCTGACCCTGCTGGAGTCTGTCCCCTGGGCTAC
CCTCTGCTTCCCCCCATTGTGAGTGGTCCGTGAAGCACAGCGTTGACCAGACCTAAACCTGTTTGCTCCCAGGACAAGGTGGAGCAGACA
CCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAA
GCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGC
CAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAG
CCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCT
GAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAG
CCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCA
AGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCAC
GGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTA
CAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGG
AGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAA
TTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGT
AGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATC
TACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAG
GCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGA
ACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAG
GTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGT
GCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAG
GAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTAC
GGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTA
CTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTAC
CTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTC
CTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTGTTTTGGGAGA
GGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGA
TGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTA
GCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGT
GAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGC
CTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTT
CGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAG
ATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAG
TTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTGGTTGCTATTT
TCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTATCTTTTTTTTAACCTTATTAAAA

>In-frame_GRB10_ENST00000439599_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_2856nt
ATGCAAGCTGCCGGCCCTCTGTTCCGTAGTAAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCC
GCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTG
TACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCT
CGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAA
GACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCG
GGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATA
GCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAAC
CCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGAT
GCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTT
CTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTAT
GTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATG
GTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTAT
GGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTG
ACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTT
CACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACA
CGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTT
TTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCA
AGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAG
ACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAG
ATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAA
GATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCA
ATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGT
AAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTGTTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAA
TTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCA
GCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTT
GGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACA
GAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTT
CACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTA
TATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTA
GTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTA
TACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTGGTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGC

>In-frame_GRB10_ENST00000398812_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_2905nt
AAATGTAATTTGAAGAAGGCAGAAGGAACCCATGGCTTTAGCCGGCTGCCCAGATTCCTTTTTGCACCATCCGTACTACCAGGACAAGGT
GGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGT
GGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCT
GCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCA
GCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAA
TCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTT
AGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGT
TTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTAT
TTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGA
AGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTT
TAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGA
TGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGA
AAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGG
ACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCT
TGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTA
CAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAG
AATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGT
AGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGA
GGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACC
TCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGA
TGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGC
CAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCAC
AGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTG
TTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCAC
TTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATAC
AAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTG
AGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTC
AACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGA
AGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATA
ATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAAT
GCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTG
GTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTATCTTTTTTTTAAC

>In-frame_GRB10_ENST00000402578_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_2965nt
ACCGACTCTGTGAATTGGGTACCTTCATGATACCCATTTTATAAATGAGAAAACTGAGGTTTTTACTATATGCTGGTCATCATGCTGAGG
ACTTTACTTGGATTTTCTCTCCTGCCAATGCTACGCGGTGGGGACCTTCATGTTCTCCCCTTTGCAGATGAGATTATCAAAGCAGAAAAA
GACCATCTCTCCTACTGAGTAACAGAGGAAACCAGGGCTTGCAGATATTGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAA
TGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCC
TCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGT
CAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAG
CCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGG
TGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGAC
TGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTT
CGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAA
GAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGA
TGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGAT
GGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAA
CTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAA
TGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTC
CCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCA
GGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTC
ACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAA
AGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGG
AGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGG
AAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGAT
ATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGG
AAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAA
GTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTGTTTTGGGAGAGGAACGGGAAAAGCTTTTTG
CTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGATGAGGTAGGCGGATCACTGG
GGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTAGCTGCGCGTGGTGGTGCACG
CCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGTGAGCCAGGATTGCGCCACCA
CACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGCCTATTTTTTAATGCTTAGTT
TTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTTCGTTATGGGCCAATATTAGC
TCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAGATTTGTCAGATAGGAAATTT
TATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAGTTATTCTCTTTTCTATAGAT
TGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTGGTTGCTATTTTCCTTCTTTAGTCAATATGA

>In-frame_GRB10_ENST00000357271_chr7_50737419_-_SCIN_ENST00000297029_chr7_12662426_+_2905nt
AAATGTAATTTGAAGAAGGCAGAAGGAACCCATGGCTTTAGCCGGCTGCCCAGATTCCTTTTTGCACCATCCGTACTACCAGGACAAGGT
GGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGT
GGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCT
GCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCA
GCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAA
TCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTT
AGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGT
TTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTAT
TTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGA
AGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTT
TAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGA
TGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGA
AAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGG
ACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCT
TGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTA
CAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAG
AATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGT
AGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGA
GGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACC
TCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGA
TGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGC
CAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCAC
AGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTG
TTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCAC
TTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATAC
AAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTG
AGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTC
AACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGA
AGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATA
ATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAAT
GCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTG
GTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTATCTTTTTTTTAAC


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FusionGenePPI for GRB10_SCIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRB10GIGYF2, GIGYF1, IGF1R, SRC, FYN, INSR, IRS1, RAF1, KDR, EGFR, KIT, MAP2K1, RET, EPHB1, GHR, JAK2, ABL1, NEDD4, NOA1, MEGF10, ELAVL1, PIK3R1, IRS2, APP, DENND5B, IQCB1, RQCD1, HECW2, AKT1, YWHAE, ZDHHC17, CHFR, NARS, BAIAP2, RCAN3, XPO1, NEDD4L, WDR59SCINACTA1, BAG3, OBSL1, CCDC8, TMOD1, TMOD2, ACTR1B, SSH1, TMOD3, BCL7C, BCL7A, LSP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRB10_SCIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRB10_SCIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB10C0036341Schizophrenia1PSYGENET