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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15350

FusionGeneSummary for GRB10_MAD1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB10_MAD1L1
Fusion gene ID: 15350
HgeneTgene
Gene symbol

GRB10

MAD1L1

Gene ID

2887

8379

Gene namegrowth factor receptor bound protein 10mitotic arrest deficient 1 like 1
SynonymsGRB-IR|Grb-10|IRBP|MEG1|RSSMAD1|PIG9|TP53I9|TXBP181
Cytomap

7p12.1

7p22.3

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1mitotic spindle assembly checkpoint protein MAD1MAD1 mitotic arrest deficient like 1MAD1-like protein 1mitotic arrest deficient 1-like protein 1mitotic checkpoint MAD1 protein homologmitotic-arrest deficient 1, yeast, homolog-like 1tax-binding prote
Modification date2018052220180523
UniProtAcc

Q13322

Q9Y6D9

Ensembl transtripts involved in fusion geneENST00000398810, ENST00000439599, 
ENST00000398812, ENST00000335866, 
ENST00000402578, ENST00000403097, 
ENST00000406641, ENST00000357271, 
ENST00000407526, ENST00000401949, 
ENST00000402497, ENST00000483819, 
ENST00000402746, ENST00000399654, 
ENST00000406869, ENST00000265854, 
ENST00000486340, 
Fusion gene scores* DoF score10 X 6 X 8=48010 X 12 X 9=1080
# samples 1018
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1080*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB10 [Title/Abstract] AND MAD1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB10

GO:0030178

negative regulation of Wnt signaling pathway

17376403

HgeneGRB10

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

15060076

TgeneMAD1L1

GO:0090235

regulation of metaphase plate congression

20133940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-05-4415-01AGRB10chr7

50823584

-MAD1L1chr7

2188873

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398810ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398810ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398810ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398810ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-intronENST00000398810ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000439599ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000439599ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000439599ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000439599ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-intronENST00000439599ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398812ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398812ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398812ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000398812ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-intronENST00000398812ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000335866ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000335866ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000335866ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000335866ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-intronENST00000335866ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402578ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402578ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402578ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402578ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-intronENST00000402578ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000403097ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000403097ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000403097ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000403097ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-intronENST00000403097ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000406641ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000406641ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000406641ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000406641ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-intronENST00000406641ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000357271ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000357271ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000357271ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000357271ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-intronENST00000357271ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000407526ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000407526ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000407526ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000407526ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-intronENST00000407526ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000401949ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000401949ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000401949ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-3CDSENST00000401949ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5UTR-intronENST00000401949ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402497ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402497ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402497ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-3CDSENST00000402497ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
intron-intronENST00000402497ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-
Frame-shitENST00000483819ENST00000402746GRB10chr7

50823584

-MAD1L1chr7

2188873

-
Frame-shitENST00000483819ENST00000399654GRB10chr7

50823584

-MAD1L1chr7

2188873

-
Frame-shitENST00000483819ENST00000406869GRB10chr7

50823584

-MAD1L1chr7

2188873

-
Frame-shitENST00000483819ENST00000265854GRB10chr7

50823584

-MAD1L1chr7

2188873

-
5CDS-intronENST00000483819ENST00000486340GRB10chr7

50823584

-MAD1L1chr7

2188873

-

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FusionProtFeatures for GRB10_MAD1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB10

Q13322

MAD1L1

Q9Y6D9

Component of the spindle-assembly checkpoint thatprevents the onset of anaphase until all chromosomes are properlyaligned at the metaphase plate. May recruit MAD2L1 to unattachedkinetochores. Has a role in the correct positioning of the septum.Required for anchoring MAD2L1 to the nuclear periphery. Binds tothe TERT promoter and represses telomerase expression, possibly byinterfering with MYC binding. {ECO:0000269|PubMed:10049595,ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:20133940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRB10_MAD1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRB10_MAD1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRB10GIGYF2, GIGYF1, IGF1R, SRC, FYN, INSR, IRS1, RAF1, KDR, EGFR, KIT, MAP2K1, RET, EPHB1, GHR, JAK2, ABL1, NEDD4, NOA1, MEGF10, ELAVL1, PIK3R1, IRS2, APP, DENND5B, IQCB1, RQCD1, HECW2, AKT1, YWHAE, ZDHHC17, CHFR, NARS, BAIAP2, RCAN3, XPO1, NEDD4L, WDR59MAD1L1TEX11, NINL, NONO, FAM131C, TRIM29, AMOTL2, TUBGCP4, MAD1L1, MAD2L1, HDAC1, HDAC2, MNT, NRD1, MAD2L1BP, CDC27, COIL, UBC, METTL21C, ZW10, SIN3A, BAG5, FLNB, ZZEF1, CDC20, TPR, TRIP13, ALOX5, TSC22D3, MFAP1, PSMA1, TPM1, TPM3, RNF8, SPATA2, USP15, NEBL, LGALSL, CCHCR1, ZSCAN32, CCDC94, TSHZ3, HAUS1, CWF19L2, CLEC11A, KCNAB3, VPS28, SCARA3, IKZF3, NUDC, STK24, NTRK1, APC, FOXJ2, SNW1, CDC5L, SENP3, PTRF, ZADH2, BMP1, ASB7, HSPA8, C6orf141


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRB10_MAD1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRB10_MAD1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB10C0036341Schizophrenia1PSYGENET
TgeneMAD1L1C0036341Schizophrenia1PSYGENET
TgeneMAD1L1C1336708Testicular Germ Cell Tumor1CTD_human
TgeneMAD1L1C3495559Juvenile arthritis1CTD_human