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Fusion gene ID: 15349 |
FusionGeneSummary for GRB10_EEPD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRB10_EEPD1 | Fusion gene ID: 15349 | Hgene | Tgene | Gene symbol | GRB10 | EEPD1 | Gene ID | 2887 | 80820 |
| Gene name | growth factor receptor bound protein 10 | endonuclease/exonuclease/phosphatase family domain containing 1 | |
| Synonyms | GRB-IR|Grb-10|IRBP|MEG1|RSS | HSPC107 | |
| Cytomap | 7p12.1 | 7p14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | growth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1 | endonuclease/exonuclease/phosphatase family domain-containing protein 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q13322 | Q7L9B9 | |
| Ensembl transtripts involved in fusion gene | ENST00000398810, ENST00000439599, ENST00000398812, ENST00000335866, ENST00000402578, ENST00000403097, ENST00000406641, ENST00000357271, ENST00000407526, ENST00000401949, ENST00000402497, ENST00000483819, | ENST00000242108, ENST00000534978, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 4 X 3 X 3=36 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GRB10 [Title/Abstract] AND EEPD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRB10 | GO:0030178 | negative regulation of Wnt signaling pathway | 17376403 |
| Hgene | GRB10 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 15060076 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-14-0736-02A | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000398810 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000398810 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000439599 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000439599 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000398812 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000398812 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000335866 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000335866 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000402578 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000402578 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000403097 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000403097 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| In-frame | ENST00000406641 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| In-frame | ENST00000406641 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000357271 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000357271 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000407526 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000407526 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000401949 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| Frame-shift | ENST00000401949 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| In-frame | ENST00000402497 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| In-frame | ENST00000402497 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| intron-3CDS | ENST00000483819 | ENST00000242108 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
| intron-3CDS | ENST00000483819 | ENST00000534978 | GRB10 | chr7 | 50737419 | - | EEPD1 | chr7 | 36278594 | + |
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FusionProtFeatures for GRB10_EEPD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRB10 | EEPD1 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRB10_EEPD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GRB10_ENST00000406641_chr7_50737419_-_EEPD1_ENST00000242108_chr7_36278594_+_387aa MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGP GSPPVLTPGSLPPSQAAAKQHQASSCARTAXQRGLGKVLHGAKPADPAQHPQVEGAPGMLEGCCCXEALESAPEGSWVCRIPMGRGCRHG AERRGFTGELAKQRAREAGGPQPIPREVQGGKSRPDPCXPSPGSPDPPGERESQQESQXWPPVGELCTDPTGNPERRKGCHYLRGFWPRA RQQXLXYPEERKVPPPDPRAHLHQHQHQEPSRLEVSGQHLDQXKLKEGFHRSLGCGERRPHEPLDSGXLVLGRGGFXTLPSASRVLHXKG >In-frame_GRB10_ENST00000406641_chr7_50737419_-_EEPD1_ENST00000534978_chr7_36278594_+_387aa MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGP GSPPVLTPGSLPPSQAAAKQHQASSCARTAXQRGLGKVLHGAKPADPAQHPQVEGAPGMLEGCCCXEALESAPEGSWVCRIPMGRGCRHG AERRGFTGELAKQRAREAGGPQPIPREVQGGKSRPDPCXPSPGSPDPPGERESQQESQXWPPVGELCTDPTGNPERRKGCHYLRGFWPRA RQQXLXYPEERKVPPPDPRAHLHQHQHQEPSRLEVSGQHLDQXKLKEGFHRSLGCGERRPHEPLDSGXLVLGRGGFXTLPSASRVLHXKG >In-frame_GRB10_ENST00000402497_chr7_50737419_-_EEPD1_ENST00000242108_chr7_36278594_+_387aa MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGP GSPPVLTPGSLPPSQAAAKQHQASSCARTAXQRGLGKVLHGAKPADPAQHPQVEGAPGMLEGCCCXEALESAPEGSWVCRIPMGRGCRHG AERRGFTGELAKQRAREAGGPQPIPREVQGGKSRPDPCXPSPGSPDPPGERESQQESQXWPPVGELCTDPTGNPERRKGCHYLRGFWPRA RQQXLXYPEERKVPPPDPRAHLHQHQHQEPSRLEVSGQHLDQXKLKEGFHRSLGCGERRPHEPLDSGXLVLGRGGFXTLPSASRVLHXKG >In-frame_GRB10_ENST00000402497_chr7_50737419_-_EEPD1_ENST00000534978_chr7_36278594_+_387aa MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGP GSPPVLTPGSLPPSQAAAKQHQASSCARTAXQRGLGKVLHGAKPADPAQHPQVEGAPGMLEGCCCXEALESAPEGSWVCRIPMGRGCRHG AERRGFTGELAKQRAREAGGPQPIPREVQGGKSRPDPCXPSPGSPDPPGERESQQESQXWPPVGELCTDPTGNPERRKGCHYLRGFWPRA RQQXLXYPEERKVPPPDPRAHLHQHQHQEPSRLEVSGQHLDQXKLKEGFHRSLGCGERRPHEPLDSGXLVLGRGGFXTLPSASRVLHXKG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GRB10_ENST00000406641_chr7_50737419_-_EEPD1_ENST00000242108_chr7_36278594_+_1162nt ATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGC CAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTC GCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCT GGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCT TGACAGAGAGGCCTTGGAAAAGTTCTGCACGGAGCTAAACCAGCCGACCCTGCCCAACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTG GAAGGCTGTTGTTGCTGAGAAGCCCTCGAGTCAGCTCCAGAAGGGAGCTGGGTATGCAGGATTCCTATGGGACGCGGCTGCCGGCATGGA GCTGAGAGACGCGGGTTCACAGGAGAGCTCGCCAAGCAACGGGCACGGGAAGCTGGCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGT GGGAAGTCACGACCTGACCCTTGTTAACCTTCACCTGGCAGCCCTGACCCTCCTGGGGAGCGAGAATCCCAGCAAGAATCACAGTGATGG CCACCGGTTGGCGAGCTTTGCACAGACCCTACAGGAAACCCTGAAAGGAGAAAAGGATGTCATTATCTTAGGGGATTTTGGCCAAGGGCC AGACAGCAATGACTATGATATCCTGAGGAAAGAAAAGTTCCACCACCTGATCCCCGCGCACACCTTCACCAACATCAGCACCAAGAACCC TCAAGGCTCGAAGTCTCTGGACAACATCTGGATCAGTAAAAGCTTAAAGAAGGTTTTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCT CACGAACCCTTGGATTCCGGATAACTGGTCTTGGGGCGGGGTGGCTTCTGAACACTGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGA >In-frame_GRB10_ENST00000406641_chr7_50737419_-_EEPD1_ENST00000534978_chr7_36278594_+_1162nt ATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGC CAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTC GCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCT GGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCT TGACAGAGAGGCCTTGGAAAAGTTCTGCACGGAGCTAAACCAGCCGACCCTGCCCAACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTG GAAGGCTGTTGTTGCTGAGAAGCCCTCGAGTCAGCTCCAGAAGGGAGCTGGGTATGCAGGATTCCTATGGGACGCGGCTGCCGGCATGGA GCTGAGAGACGCGGGTTCACAGGAGAGCTCGCCAAGCAACGGGCACGGGAAGCTGGCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGT GGGAAGTCACGACCTGACCCTTGTTAACCTTCACCTGGCAGCCCTGACCCTCCTGGGGAGCGAGAATCCCAGCAAGAATCACAGTGATGG CCACCGGTTGGCGAGCTTTGCACAGACCCTACAGGAAACCCTGAAAGGAGAAAAGGATGTCATTATCTTAGGGGATTTTGGCCAAGGGCC AGACAGCAATGACTATGATATCCTGAGGAAAGAAAAGTTCCACCACCTGATCCCCGCGCACACCTTCACCAACATCAGCACCAAGAACCC TCAAGGCTCGAAGTCTCTGGACAACATCTGGATCAGTAAAAGCTTAAAGAAGGTTTTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCT CACGAACCCTTGGATTCCGGATAACTGGTCTTGGGGCGGGGTGGCTTCTGAACACTGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGA >In-frame_GRB10_ENST00000402497_chr7_50737419_-_EEPD1_ENST00000242108_chr7_36278594_+_1162nt ATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGC CAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTC GCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCT GGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCT TGACAGAGAGGCCTTGGAAAAGTTCTGCACGGAGCTAAACCAGCCGACCCTGCCCAACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTG GAAGGCTGTTGTTGCTGAGAAGCCCTCGAGTCAGCTCCAGAAGGGAGCTGGGTATGCAGGATTCCTATGGGACGCGGCTGCCGGCATGGA GCTGAGAGACGCGGGTTCACAGGAGAGCTCGCCAAGCAACGGGCACGGGAAGCTGGCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGT GGGAAGTCACGACCTGACCCTTGTTAACCTTCACCTGGCAGCCCTGACCCTCCTGGGGAGCGAGAATCCCAGCAAGAATCACAGTGATGG CCACCGGTTGGCGAGCTTTGCACAGACCCTACAGGAAACCCTGAAAGGAGAAAAGGATGTCATTATCTTAGGGGATTTTGGCCAAGGGCC AGACAGCAATGACTATGATATCCTGAGGAAAGAAAAGTTCCACCACCTGATCCCCGCGCACACCTTCACCAACATCAGCACCAAGAACCC TCAAGGCTCGAAGTCTCTGGACAACATCTGGATCAGTAAAAGCTTAAAGAAGGTTTTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCT CACGAACCCTTGGATTCCGGATAACTGGTCTTGGGGCGGGGTGGCTTCTGAACACTGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGA >In-frame_GRB10_ENST00000402497_chr7_50737419_-_EEPD1_ENST00000534978_chr7_36278594_+_1162nt ATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGC CAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTC GCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCT GGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCT TGACAGAGAGGCCTTGGAAAAGTTCTGCACGGAGCTAAACCAGCCGACCCTGCCCAACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTG GAAGGCTGTTGTTGCTGAGAAGCCCTCGAGTCAGCTCCAGAAGGGAGCTGGGTATGCAGGATTCCTATGGGACGCGGCTGCCGGCATGGA GCTGAGAGACGCGGGTTCACAGGAGAGCTCGCCAAGCAACGGGCACGGGAAGCTGGCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGT GGGAAGTCACGACCTGACCCTTGTTAACCTTCACCTGGCAGCCCTGACCCTCCTGGGGAGCGAGAATCCCAGCAAGAATCACAGTGATGG CCACCGGTTGGCGAGCTTTGCACAGACCCTACAGGAAACCCTGAAAGGAGAAAAGGATGTCATTATCTTAGGGGATTTTGGCCAAGGGCC AGACAGCAATGACTATGATATCCTGAGGAAAGAAAAGTTCCACCACCTGATCCCCGCGCACACCTTCACCAACATCAGCACCAAGAACCC TCAAGGCTCGAAGTCTCTGGACAACATCTGGATCAGTAAAAGCTTAAAGAAGGTTTTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCT CACGAACCCTTGGATTCCGGATAACTGGTCTTGGGGCGGGGTGGCTTCTGAACACTGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GRB10_ENST00000406641_chr7_50737419_-_EEPD1_ENST00000242108_chr7_36278594_+_3984nt CTTTCCAGCTTTGGCGCTGACCACAATGCTGAGCAGGAAGCAGCAGCTGCAGGCCCAGTGACTGGTAGCTCAGTGACCAGCAGCCCAGTG ACCGGCAGCCAGGTCCTCACCTGGGTCCTCTCAGTGAAGCCAGGGTGGCCGCCCCAGCAGACAGTGCTACAGAGCCAACTCCTGACAGAT ATTCTGGAGGAAGGTGTGAACGCAACTTTGCCTCCCAGGGAACAAACATCCTCCTTCTAAGTGGTAGATGTGGGTGAGCTGACCCTGCTG GAGTCTGTCCCCTGGGCTACCCTCTGCTTCCCCCCATTGTGAGTGGTCCGTGAAGCACAGCGTTGACCAGACCTAAACCTGTTTGCTCCC AGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGG AGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGG TGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGC AGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGG CCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAA AGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCTTGACAGAGAGGCCTTGGAAAAGTTCTGCACGGAGCTAAACCAGCCGACCCTGCCC AACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTGGAAGGCTGTTGTTGCTGAGAAGCCCTCGAGTCAGCTCCAGAAGGGAGCTGGGTAT GCAGGATTCCTATGGGACGCGGCTGCCGGCATGGAGCTGAGAGACGCGGGTTCACAGGAGAGCTCGCCAAGCAACGGGCACGGGAAGCTG GCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGTGGGAAGTCACGACCTGACCCTTGTTAACCTTCACCTGGCAGCCCTGACCCTCCTG GGGAGCGAGAATCCCAGCAAGAATCACAGTGATGGCCACCGGTTGGCGAGCTTTGCACAGACCCTACAGGAAACCCTGAAAGGAGAAAAG GATGTCATTATCTTAGGGGATTTTGGCCAAGGGCCAGACAGCAATGACTATGATATCCTGAGGAAAGAAAAGTTCCACCACCTGATCCCC GCGCACACCTTCACCAACATCAGCACCAAGAACCCTCAAGGCTCGAAGTCTCTGGACAACATCTGGATCAGTAAAAGCTTAAAGAAGGTT TTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCTCACGAACCCTTGGATTCCGGATAACTGGTCTTGGGGCGGGGTGGCTTCTGAACAC TGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGACTGGAGCAAGAAGGATGCCCCTCGGAACGGCAGCGGGGTGGCCTTGGAGCGAAGT GAAGCCAACATCAAGCACGAGCGATGATGACACCAAATCCATGTGTCCACCCTGGGACCCAGGAGGGCACAGCCAAGGAATGAGCCCTGT GGGGTGACGCTTCAGGGCAGAGCTGCCTTTTAATTTTTATTCTCAGAGCATCAGCACTTGAGGCCTTGCCCCACGCCTTCTCTGTGGACC ATTCAGGACCTCCAGTGGGGGTGGCGTGCCAGGCGCGTACCCCACCAGGTGGGCAAAGCAGAAACCTGCGGGGAGCGGAGACGCCTTTTA TCTCTGGATGCCACAGACCTGAGCAGCATTGGGCTGGCTGTCCGCTGCTGACTGGATGGCAGCACAAAGACAATATGAGCAGAGGGAGGA GAAGAAGGGGTGCTCAGGCTGCGGGCCACAGTCCAGCAGCGCCAGAAGCACTCATTTCTGACCACCAGGCTATGACGTTCCTGCTGCGCA TTACAGAAAGCTTTTAACTGTGATCAGGCACTCTGCTCAGATACATTGAGTGGCGATTTTTAGTTTTGTTTTGAAAAAATAAACAGATTA ACCTGCCTCGCTGCAGTGAGAGCATGGGACAAGTCCGCCACAGCCCTCCCCCGCCCCCTTCCCCCGCCCCCCAACGCGCAGTGTGTATTT GCACCACGGCAGGTGCCTCTGTGTGGAGCTAGGGTCAAGCCCTGAGCAGCTTCACTTCCCCTGCGCCTTTTATGTCCCCACCTTGAGGCC TTGCAGAGGCGCCTCTCAAGGCCCCATCAGCTCGCCGGGACCTCTGTGAAGCCTCTCTGTCATCTCCCCTTCCCAGCCCCTCCTTCATCC CCTGCCTCCTTCACCAGCCTGGCTTTTGCCTGGAGCACTATTTGTTTAGTTCTCTTTGCAGGACAAGAATTCTCTCAGGGTGGTATCACC TCCTCCCTCCTCCCCACTCACTCCAGTTTTTAGCCCGGAGCCTCCTGTGGTTGACTATCAGGAATGTGTGCTGTGTCAGGATACATAGGA AGTTGACCTCGGGGTATCATGGAGAGTGTCCCTCCTAGTGGCTGGAGGTAGGGACAGTTGGTTGTGGGGCTGGAGAGAGGTTGTGGGGAG GAAGCGAGGATGCGTGCCTGCCACTAGGCATCTGCATCCCCGAGCCCAAGCCAGGAGGGATTTCCCTTAGGCAACACCATCCCAGGGAGA TCTGCCACAATTTGCGTTTCACAGCTGAAGACGCTGAGGCTTAGAGAGCTCGACCTCCTCAAGGTCACACCACTGGGTAAATAGAGGGAT GCAGACTCAGGTTTTGCTATGTGCTCACATTTCAACTTTATGCTTAACATGAATGGAAAAATATGAAAGTAAATAGTGAAAAGGTAAGTT ATGAGCTTAGATTACCTAGATTATTCCAGTATCCCATGGAAGCTGAGGACTTATTCCGCTTTCCACACCGAACACTAAATGTGGACCAGT ATCAAGAACCCTCCTGTCCCCACGCAGTGTAAACCCAGTGGCTTCTCTGACCTGGAGCTGATGGGCCGTGAAGGGGGCCTATTTTTCTCC AAAGGCCATCCTTTTGGGGCCACCTGGCTCCAAGAAGCATCGCTGGTCTTGGGGACGGGAAGGGAACCCTCTTCCAGGAGCTCTAAGGGT ACTTGGGAATCAATTGTGTCCATTCTGAGGTCTCTCCAGTGGGAGGGCGGCAGCTCCTGTCCCTGGGTTCAGGCTGTGCTTCTGGAAGCA TCGAAATGGGATGTCTGAGCCTTGAGGAAAAGCAGCAGGGTTAGCATTAAAGTCAAGAGGGGCAGCTCAGGATGCTACCAGGGAGCACAT CGTTTCTGGTGCCTCATCTAAAGGTGAAACCTCCCCTACATTCACCAGCCGGATGTCCCAAATCCCTTTAGCCAGATTGCTTTTTGCAAC CAAAGCTGTGGACAGAAAAGCCTCCTTAAGTGAGCTGAGGGGACAGGAAATCCAATCAGATGACCTTTGTGTTCGTAATCGGGCTTGAGC CAGAGGCTGGGGAGCTGAGTCCCAGCCAAACCTCACTGGCCCTTTTGCTTTTCACGCCCAGGGCTCAGTGGCCCAGGAAGTGTGCTGGGC AGCCTGTTCTTACTCCAGCTCAACCCATTGGGTGTTGGCTGTTTTTGGTTTTAGTTGTTGTTTTGTATTTTGTTGTTTTAATTAATAGGC TTTATTTGTAAGAGCAGTTTTATGTTTACAGAAAAATTAGGCACAAAGGGATTCCCATATCCCTCCTCTTCTTTGCATATTTCCCCCTCT AATTAGCATGTTGCATTAGCATGGCACTTTGTTACAACTGATGAACTTGTATTCATTATTAGCTACAGTGTTCATAGTTTATATTAAAGT >In-frame_GRB10_ENST00000406641_chr7_50737419_-_EEPD1_ENST00000534978_chr7_36278594_+_2166nt CTTTCCAGCTTTGGCGCTGACCACAATGCTGAGCAGGAAGCAGCAGCTGCAGGCCCAGTGACTGGTAGCTCAGTGACCAGCAGCCCAGTG ACCGGCAGCCAGGTCCTCACCTGGGTCCTCTCAGTGAAGCCAGGGTGGCCGCCCCAGCAGACAGTGCTACAGAGCCAACTCCTGACAGAT ATTCTGGAGGAAGGTGTGAACGCAACTTTGCCTCCCAGGGAACAAACATCCTCCTTCTAAGTGGTAGATGTGGGTGAGCTGACCCTGCTG GAGTCTGTCCCCTGGGCTACCCTCTGCTTCCCCCCATTGTGAGTGGTCCGTGAAGCACAGCGTTGACCAGACCTAAACCTGTTTGCTCCC AGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGG AGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGG TGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGC AGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGG CCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAA AGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCTTGACAGAGAGGCCTTGGAAAAGTTCTGCACGGAGCTAAACCAGCCGACCCTGCCC AACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTGGAAGGCTGTTGTTGCTGAGAAGCCCTCGAGTCAGCTCCAGAAGGGAGCTGGGTAT GCAGGATTCCTATGGGACGCGGCTGCCGGCATGGAGCTGAGAGACGCGGGTTCACAGGAGAGCTCGCCAAGCAACGGGCACGGGAAGCTG GCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGTGGGAAGTCACGACCTGACCCTTGTTAACCTTCACCTGGCAGCCCTGACCCTCCTG GGGAGCGAGAATCCCAGCAAGAATCACAGTGATGGCCACCGGTTGGCGAGCTTTGCACAGACCCTACAGGAAACCCTGAAAGGAGAAAAG GATGTCATTATCTTAGGGGATTTTGGCCAAGGGCCAGACAGCAATGACTATGATATCCTGAGGAAAGAAAAGTTCCACCACCTGATCCCC GCGCACACCTTCACCAACATCAGCACCAAGAACCCTCAAGGCTCGAAGTCTCTGGACAACATCTGGATCAGTAAAAGCTTAAAGAAGGTT TTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCTCACGAACCCTTGGATTCCGGATAACTGGTCTTGGGGCGGGGTGGCTTCTGAACAC TGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGACTGGAGCAAGAAGGATGCCCCTCGGAACGGCAGCGGGGTGGCCTTGGAGCGAAGT GAAGCCAACATCAAGCACGAGCGATGATGACACCAAATCCATGTGTCCACCCTGGGACCCAGGAGGGCACAGCCAAGGAATGAGCCCTGT GGGGTGACGCTTCAGGGCAGAGCTGCCTTTTAATTTTTATTCTCAGAGCATCAGCACTTGAGGCCTTGCCCCACGCCTTCTCTGTGGACC ATTCAGGACCTCCAGTGGGGGTGGCGTGCCAGGCGCGTACCCCACCAGGTGGGCAAAGCAGAAACCTGCGGGGAGCGGAGACGCCTTTTA TCTCTGGATGCCACAGACCTGAGCAGCATTGGGCTGGCTGTCCGCTGCTGACTGGATGGCAGCACAAAGACAATATGAGCAGAGGGAGGA GAAGAAGGGGTGCTCAGGCTGCGGGCCACAGTCCAGCAGCGCCAGAAGCACTCATTTCTGACCACCAGGCTATGACGTTCCTGCTGCGCA TTACAGAAAGCTTTTAACTGTGATCAGGCACTCTGCTCAGATACATTGAGTGGCGATTTTTAGTTTTGTTTTGAAAAAATAAACAGATTA >In-frame_GRB10_ENST00000402497_chr7_50737419_-_EEPD1_ENST00000242108_chr7_36278594_+_3835nt GAAGCGAGCTGCGGCCGGGCGGGCTCGGCGCTCGGAGACCCGGTGGAGCCCAAAGTTTCCGCGCAGCCCCTGGGTGGCGGCAGCGCCGGC GGCGCGGGGCGCCCGGGACAGTCTTGAGCGCCGGCCTCGCCCCGCGGGGACCCGCGCCCGCCGCCGGCCACGCCGAGTGTCGCCCGCAGC CACGCGGAGGCGGCGGGGAGCCGCGCGCGGCAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCC GCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTG TACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCT CGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAA GACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCG GGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCTTGACAGAGAGGCCTTGGAAAAGTT CTGCACGGAGCTAAACCAGCCGACCCTGCCCAACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTGGAAGGCTGTTGTTGCTGAGAAGCC CTCGAGTCAGCTCCAGAAGGGAGCTGGGTATGCAGGATTCCTATGGGACGCGGCTGCCGGCATGGAGCTGAGAGACGCGGGTTCACAGGA GAGCTCGCCAAGCAACGGGCACGGGAAGCTGGCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGTGGGAAGTCACGACCTGACCCTTGT TAACCTTCACCTGGCAGCCCTGACCCTCCTGGGGAGCGAGAATCCCAGCAAGAATCACAGTGATGGCCACCGGTTGGCGAGCTTTGCACA GACCCTACAGGAAACCCTGAAAGGAGAAAAGGATGTCATTATCTTAGGGGATTTTGGCCAAGGGCCAGACAGCAATGACTATGATATCCT GAGGAAAGAAAAGTTCCACCACCTGATCCCCGCGCACACCTTCACCAACATCAGCACCAAGAACCCTCAAGGCTCGAAGTCTCTGGACAA CATCTGGATCAGTAAAAGCTTAAAGAAGGTTTTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCTCACGAACCCTTGGATTCCGGATAA CTGGTCTTGGGGCGGGGTGGCTTCTGAACACTGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGACTGGAGCAAGAAGGATGCCCCTCG GAACGGCAGCGGGGTGGCCTTGGAGCGAAGTGAAGCCAACATCAAGCACGAGCGATGATGACACCAAATCCATGTGTCCACCCTGGGACC CAGGAGGGCACAGCCAAGGAATGAGCCCTGTGGGGTGACGCTTCAGGGCAGAGCTGCCTTTTAATTTTTATTCTCAGAGCATCAGCACTT GAGGCCTTGCCCCACGCCTTCTCTGTGGACCATTCAGGACCTCCAGTGGGGGTGGCGTGCCAGGCGCGTACCCCACCAGGTGGGCAAAGC AGAAACCTGCGGGGAGCGGAGACGCCTTTTATCTCTGGATGCCACAGACCTGAGCAGCATTGGGCTGGCTGTCCGCTGCTGACTGGATGG CAGCACAAAGACAATATGAGCAGAGGGAGGAGAAGAAGGGGTGCTCAGGCTGCGGGCCACAGTCCAGCAGCGCCAGAAGCACTCATTTCT GACCACCAGGCTATGACGTTCCTGCTGCGCATTACAGAAAGCTTTTAACTGTGATCAGGCACTCTGCTCAGATACATTGAGTGGCGATTT TTAGTTTTGTTTTGAAAAAATAAACAGATTAACCTGCCTCGCTGCAGTGAGAGCATGGGACAAGTCCGCCACAGCCCTCCCCCGCCCCCT TCCCCCGCCCCCCAACGCGCAGTGTGTATTTGCACCACGGCAGGTGCCTCTGTGTGGAGCTAGGGTCAAGCCCTGAGCAGCTTCACTTCC CCTGCGCCTTTTATGTCCCCACCTTGAGGCCTTGCAGAGGCGCCTCTCAAGGCCCCATCAGCTCGCCGGGACCTCTGTGAAGCCTCTCTG TCATCTCCCCTTCCCAGCCCCTCCTTCATCCCCTGCCTCCTTCACCAGCCTGGCTTTTGCCTGGAGCACTATTTGTTTAGTTCTCTTTGC AGGACAAGAATTCTCTCAGGGTGGTATCACCTCCTCCCTCCTCCCCACTCACTCCAGTTTTTAGCCCGGAGCCTCCTGTGGTTGACTATC AGGAATGTGTGCTGTGTCAGGATACATAGGAAGTTGACCTCGGGGTATCATGGAGAGTGTCCCTCCTAGTGGCTGGAGGTAGGGACAGTT GGTTGTGGGGCTGGAGAGAGGTTGTGGGGAGGAAGCGAGGATGCGTGCCTGCCACTAGGCATCTGCATCCCCGAGCCCAAGCCAGGAGGG ATTTCCCTTAGGCAACACCATCCCAGGGAGATCTGCCACAATTTGCGTTTCACAGCTGAAGACGCTGAGGCTTAGAGAGCTCGACCTCCT CAAGGTCACACCACTGGGTAAATAGAGGGATGCAGACTCAGGTTTTGCTATGTGCTCACATTTCAACTTTATGCTTAACATGAATGGAAA AATATGAAAGTAAATAGTGAAAAGGTAAGTTATGAGCTTAGATTACCTAGATTATTCCAGTATCCCATGGAAGCTGAGGACTTATTCCGC TTTCCACACCGAACACTAAATGTGGACCAGTATCAAGAACCCTCCTGTCCCCACGCAGTGTAAACCCAGTGGCTTCTCTGACCTGGAGCT GATGGGCCGTGAAGGGGGCCTATTTTTCTCCAAAGGCCATCCTTTTGGGGCCACCTGGCTCCAAGAAGCATCGCTGGTCTTGGGGACGGG AAGGGAACCCTCTTCCAGGAGCTCTAAGGGTACTTGGGAATCAATTGTGTCCATTCTGAGGTCTCTCCAGTGGGAGGGCGGCAGCTCCTG TCCCTGGGTTCAGGCTGTGCTTCTGGAAGCATCGAAATGGGATGTCTGAGCCTTGAGGAAAAGCAGCAGGGTTAGCATTAAAGTCAAGAG GGGCAGCTCAGGATGCTACCAGGGAGCACATCGTTTCTGGTGCCTCATCTAAAGGTGAAACCTCCCCTACATTCACCAGCCGGATGTCCC AAATCCCTTTAGCCAGATTGCTTTTTGCAACCAAAGCTGTGGACAGAAAAGCCTCCTTAAGTGAGCTGAGGGGACAGGAAATCCAATCAG ATGACCTTTGTGTTCGTAATCGGGCTTGAGCCAGAGGCTGGGGAGCTGAGTCCCAGCCAAACCTCACTGGCCCTTTTGCTTTTCACGCCC AGGGCTCAGTGGCCCAGGAAGTGTGCTGGGCAGCCTGTTCTTACTCCAGCTCAACCCATTGGGTGTTGGCTGTTTTTGGTTTTAGTTGTT GTTTTGTATTTTGTTGTTTTAATTAATAGGCTTTATTTGTAAGAGCAGTTTTATGTTTACAGAAAAATTAGGCACAAAGGGATTCCCATA TCCCTCCTCTTCTTTGCATATTTCCCCCTCTAATTAGCATGTTGCATTAGCATGGCACTTTGTTACAACTGATGAACTTGTATTCATTAT >In-frame_GRB10_ENST00000402497_chr7_50737419_-_EEPD1_ENST00000534978_chr7_36278594_+_2017nt GAAGCGAGCTGCGGCCGGGCGGGCTCGGCGCTCGGAGACCCGGTGGAGCCCAAAGTTTCCGCGCAGCCCCTGGGTGGCGGCAGCGCCGGC GGCGCGGGGCGCCCGGGACAGTCTTGAGCGCCGGCCTCGCCCCGCGGGGACCCGCGCCCGCCGCCGGCCACGCCGAGTGTCGCCCGCAGC CACGCGGAGGCGGCGGGGAGCCGCGCGCGGCAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCC GCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTG TACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCT CGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAA GACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCG GGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGCATCAAGCTTCTAGCTGTGCAAGAACTGCTTGACAGAGAGGCCTTGGAAAAGTT CTGCACGGAGCTAAACCAGCCGACCCTGCCCAACATCCGCAAGTGGAAGGGGCCCCGGGGATGCTGGAAGGCTGTTGTTGCTGAGAAGCC CTCGAGTCAGCTCCAGAAGGGAGCTGGGTATGCAGGATTCCTATGGGACGCGGCTGCCGGCATGGAGCTGAGAGACGCGGGTTCACAGGA GAGCTCGCCAAGCAACGGGCACGGGAAGCTGGCGGGCCCCAGCCCATACCTCGGGAGGTTCAAGGTGGGAAGTCACGACCTGACCCTTGT TAACCTTCACCTGGCAGCCCTGACCCTCCTGGGGAGCGAGAATCCCAGCAAGAATCACAGTGATGGCCACCGGTTGGCGAGCTTTGCACA GACCCTACAGGAAACCCTGAAAGGAGAAAAGGATGTCATTATCTTAGGGGATTTTGGCCAAGGGCCAGACAGCAATGACTATGATATCCT GAGGAAAGAAAAGTTCCACCACCTGATCCCCGCGCACACCTTCACCAACATCAGCACCAAGAACCCTCAAGGCTCGAAGTCTCTGGACAA CATCTGGATCAGTAAAAGCTTAAAGAAGGTTTTCACAGGTCACTGGGCTGTGGTGAGAGAAGGCCTCACGAACCCTTGGATTCCGGATAA CTGGTCTTGGGGCGGGGTGGCTTCTGAACACTGCCCAGTGCTAGCCGAGTTCTACACTGAAAAGGACTGGAGCAAGAAGGATGCCCCTCG GAACGGCAGCGGGGTGGCCTTGGAGCGAAGTGAAGCCAACATCAAGCACGAGCGATGATGACACCAAATCCATGTGTCCACCCTGGGACC CAGGAGGGCACAGCCAAGGAATGAGCCCTGTGGGGTGACGCTTCAGGGCAGAGCTGCCTTTTAATTTTTATTCTCAGAGCATCAGCACTT GAGGCCTTGCCCCACGCCTTCTCTGTGGACCATTCAGGACCTCCAGTGGGGGTGGCGTGCCAGGCGCGTACCCCACCAGGTGGGCAAAGC AGAAACCTGCGGGGAGCGGAGACGCCTTTTATCTCTGGATGCCACAGACCTGAGCAGCATTGGGCTGGCTGTCCGCTGCTGACTGGATGG CAGCACAAAGACAATATGAGCAGAGGGAGGAGAAGAAGGGGTGCTCAGGCTGCGGGCCACAGTCCAGCAGCGCCAGAAGCACTCATTTCT GACCACCAGGCTATGACGTTCCTGCTGCGCATTACAGAAAGCTTTTAACTGTGATCAGGCACTCTGCTCAGATACATTGAGTGGCGATTT |
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FusionGenePPI for GRB10_EEPD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GRB10 | GIGYF2, GIGYF1, IGF1R, SRC, FYN, INSR, IRS1, RAF1, KDR, EGFR, KIT, MAP2K1, RET, EPHB1, GHR, JAK2, ABL1, NEDD4, NOA1, MEGF10, ELAVL1, PIK3R1, IRS2, APP, DENND5B, IQCB1, RQCD1, HECW2, AKT1, YWHAE, ZDHHC17, CHFR, NARS, BAIAP2, RCAN3, XPO1, NEDD4L, WDR59 | EEPD1 | APP, CIAO1, FSD1, FYTTD1, TMEM185A, PCDHGC3, MED21, ISG20, GJB7, SDC1, TIGD5, NCSTN, RSBN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRB10_EEPD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRB10_EEPD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRB10 | C0036341 | Schizophrenia | 1 | PSYGENET |
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