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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15339

FusionGeneSummary for GRAMD3_GLUL

check button Fusion gene summary
Fusion gene informationFusion gene name: GRAMD3_GLUL
Fusion gene ID: 15339
HgeneTgene
Gene symbol

GRAMD3

GLUL

Gene ID

2752

Gene nameglutamate-ammonia ligase
SynonymsGLNS|GS|PIG43|PIG59
Cytomap

1q25.3

Type of geneprotein-coding
Descriptionglutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthaseproliferation-inducing protein 43
Modification date20180522
UniProtAcc

P15104

Ensembl transtripts involved in fusion geneENST00000513040, ENST00000285689, 
ENST00000515200, ENST00000544396, 
ENST00000542322, ENST00000514932, 
ENST00000543198, ENST00000502348, 
ENST00000511134, 		ENST00000331872, 
ENST00000417584, ENST00000311223, 
ENST00000491322, ENST00000339526, 
Fusion gene scores* DoF score2 X 4 X 1=814 X 15 X 5=1050
# samples 517
** MAII scorelog2(5/8*10)=2.64385618977472log2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRAMD3 [Title/Abstract] AND GLUL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLUL

GO:0008283

cell proliferation

18662667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF925573GRAMD3chr5

125827422

+GLULchr1

182352256

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000513040ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000513040ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000513040ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000513040ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000513040ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000285689ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000285689ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000285689ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000285689ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000285689ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000515200ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000515200ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000515200ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000515200ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000515200ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000544396ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000544396ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000544396ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000544396ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000544396ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000542322ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000542322ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000542322ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000542322ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000542322ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000514932ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000514932ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000514932ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000514932ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000514932ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000543198ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000543198ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000543198ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000543198ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000543198ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000502348ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000502348ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000502348ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000502348ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000502348ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000511134ENST00000331872GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000511134ENST00000417584GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000511134ENST00000311223GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-5UTRENST00000511134ENST00000491322GRAMD3chr5

125827422

+GLULchr1

182352256

-
intron-3UTRENST00000511134ENST00000339526GRAMD3chr5

125827422

+GLULchr1

182352256

-

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FusionProtFeatures for GRAMD3_GLUL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRAMD3

GLUL

P15104

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. This enzyme has 2 functions: it catalyzes the productionof glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA),the latter in a pyridoxal phosphate-independent manner (Bysimilarity). Essential for proliferation of fetal skinfibroblasts. {ECO:0000250, ECO:0000269|PubMed:18662667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRAMD3_GLUL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRAMD3_GLUL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRAMD3_GLUL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGLULP15104DB00130L-GlutamineGlutamine synthetasesmall moleculeapproved|investigational|nutraceutical
TgeneGLULP15104DB00142Glutamic AcidGlutamine synthetasesmall moleculeapproved|nutraceutical

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RelatedDiseases for GRAMD3_GLUL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGLULC0036341Schizophrenia4PSYGENET
TgeneGLULC0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneGLULC0023904Liver Neoplasms, Experimental2CTD_human
TgeneGLULC0011570Mental Depression1PSYGENET
TgeneGLULC0011581Depressive disorder1PSYGENET
TgeneGLULC0019151Hepatic Encephalopathy1CTD_human
TgeneGLULC0028754Obesity1CTD_human
TgeneGLULC0033975Psychotic Disorders1PSYGENET
TgeneGLULC0236663Alcohol withdrawal syndrome1PSYGENET
TgeneGLULC0525045Mood Disorders1PSYGENET
TgeneGLULC0752109Brain Diseases, Metabolic, Inborn1CTD_human
TgeneGLULC1864910Glutamine deficiency, congenital1CTD_human;ORPHANET;UNIPROT
TgeneGLULC2239176Liver carcinoma1CTD_human