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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15330

FusionGeneSummary for GRAMD1A_CARS

check button Fusion gene summary
Fusion gene informationFusion gene name: GRAMD1A_CARS
Fusion gene ID: 15330
HgeneTgene
Gene symbol

GRAMD1A

CARS

Gene ID

57655

833

Gene nameGRAM domain containing 1Acysteinyl-tRNA synthetase
SynonymsKIAA1533CARS1|CYSRS|MGC:11246
Cytomap

19q13.11

11p15.4

Type of geneprotein-codingprotein-coding
DescriptionGRAM domain-containing protein 1Acysteine--tRNA ligase, cytoplasmiccysteine tRNA ligase 1, cytoplasmiccysteine translase
Modification date2018051920180523
UniProtAcc

Q96CP6

P49589

Ensembl transtripts involved in fusion geneENST00000599564, ENST00000317991, 
ENST00000504615, ENST00000411896, 
ENST00000424536, ENST00000598073, 
ENST00000380525, ENST00000397111, 
ENST00000278224, ENST00000470221, 
ENST00000401769, ENST00000397114, 
Fusion gene scores* DoF score4 X 2 X 4=328 X 8 X 6=384
# samples 48
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRAMD1A [Title/Abstract] AND CARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCARS

GO:0006423

cysteinyl-tRNA aminoacylation

10908348|17303165


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI300436GRAMD1Achr19

35491390

+CARSchr11

3039741

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000599564ENST00000380525GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-3CDSENST00000599564ENST00000397111GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-3CDSENST00000599564ENST00000278224GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-intronENST00000599564ENST00000470221GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-intronENST00000599564ENST00000401769GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-intronENST00000599564ENST00000397114GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000317991ENST00000380525GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000317991ENST00000397111GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000317991ENST00000278224GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000317991ENST00000470221GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000317991ENST00000401769GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000317991ENST00000397114GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5UTR-3CDSENST00000504615ENST00000380525GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5UTR-3CDSENST00000504615ENST00000397111GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5UTR-3CDSENST00000504615ENST00000278224GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5UTR-intronENST00000504615ENST00000470221GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5UTR-intronENST00000504615ENST00000401769GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5UTR-intronENST00000504615ENST00000397114GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000411896ENST00000380525GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000411896ENST00000397111GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000411896ENST00000278224GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000411896ENST00000470221GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000411896ENST00000401769GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000411896ENST00000397114GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000424536ENST00000380525GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000424536ENST00000397111GRAMD1Achr19

35491390

+CARSchr11

3039741

-
Frame-shiftENST00000424536ENST00000278224GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000424536ENST00000470221GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000424536ENST00000401769GRAMD1Achr19

35491390

+CARSchr11

3039741

-
5CDS-intronENST00000424536ENST00000397114GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-3CDSENST00000598073ENST00000380525GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-3CDSENST00000598073ENST00000397111GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-3CDSENST00000598073ENST00000278224GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-intronENST00000598073ENST00000470221GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-intronENST00000598073ENST00000401769GRAMD1Achr19

35491390

+CARSchr11

3039741

-
intron-intronENST00000598073ENST00000397114GRAMD1Achr19

35491390

+CARSchr11

3039741

-

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FusionProtFeatures for GRAMD1A_CARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRAMD1A

Q96CP6

CARS

P49589

May play a role in tumor progression.{ECO:0000269|PubMed:27585821}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRAMD1A_CARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRAMD1A_CARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRAMD1ATLR7, GMCL1, MCOLN3, KCNK16, TMEM30A, GABRE, FAM189A2, ZACN, GRAMD3, MRPL47, HTR3C, CHRNA9, ACVR1, TCTN3, TCTN1, CTDNEP1, PTPRN, GRAMD1B, PCDHGB4, ZNRF4, HTR3A, TMX1, GPR114, CHRNA3, CD79B, PCDHB16, VNN2, TEX28, PCDHB7CARSEEF1G, PACSIN1, PACSIN2, PACSIN3, PSTPIP1, APP, APEH, CAND1, DNM1L, FAF1, GARS, GART, GFPT1, HIRIP3, HIST1H4A, IDE, JMJD6, KARS, LUC7L2, PAWR, PPAT, PPM1G, SEC23A, SHMT1, TROVE2, TTC1, XPO7, HSPA4, SEC24D, THUMPD3, SUMO2, CBS, HNRNPA1, PICALM, SBDS, SFPQ, LARS, MCFD2, PROSC, NTRK1, TRAF6, EEF1D, EEF1A1, EEF1A2, ABTB1, MLLT6, LITAF, BATF3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRAMD1A_CARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRAMD1A_CARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCARSC0001973Alcoholic Intoxication, Chronic1PSYGENET