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Fusion gene ID: 15329 |
FusionGeneSummary for GPX8_TTLL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPX8_TTLL1 | Fusion gene ID: 15329 | Hgene | Tgene | Gene symbol | GPX8 | TTLL1 | Gene ID | 493869 | 25809 |
| Gene name | glutathione peroxidase 8 (putative) | tubulin tyrosine ligase like 1 | |
| Synonyms | EPLA847|GPx-8|GSHPx-8|UNQ847 | C22orf7|HS323M22B | |
| Cytomap | 5q11.2 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable glutathione peroxidase 8 | probable tubulin polyglutamylase TTLL1PGs3catalytic subunit of neural tubulin polyglutamylasetubulin polyglutamylase complex subunit 3tubulin tyrosine ligase-like family, member 1tubulin--tyrosine ligase-like protein 1tubulin-tyrosine ligase | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8TED1 | O95922 | |
| Ensembl transtripts involved in fusion gene | ENST00000503787, ENST00000506123, ENST00000296734, ENST00000515370, | ENST00000331018, ENST00000266254, ENST00000445824, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 4=48 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GPX8 [Title/Abstract] AND TTLL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-93-8067-01A | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000503787 | ENST00000331018 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| In-frame | ENST00000503787 | ENST00000266254 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| 5CDS-intron | ENST00000503787 | ENST00000445824 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| 3UTR-3CDS | ENST00000506123 | ENST00000331018 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| 3UTR-3CDS | ENST00000506123 | ENST00000266254 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| 3UTR-intron | ENST00000506123 | ENST00000445824 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| In-frame | ENST00000296734 | ENST00000331018 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| In-frame | ENST00000296734 | ENST00000266254 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| 5CDS-intron | ENST00000296734 | ENST00000445824 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| In-frame | ENST00000515370 | ENST00000331018 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| In-frame | ENST00000515370 | ENST00000266254 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
| 5CDS-intron | ENST00000515370 | ENST00000445824 | GPX8 | chr5 | 54456071 | + | TTLL1 | chr22 | 43455533 | - |
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FusionProtFeatures for GPX8_TTLL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPX8 | TTLL1 |
| Catalytic subunit of the neuronal tubulinpolyglutamylase complex. Modifies alpha- and beta-tubulin,generating side chains of glutamate on the gamma-carboxyl groupsof specific glutamate residues within the C-terminal tail ofalpha- and beta-tubulin (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TTLL1 | chr5:54456071 | chr22:43455533 | ENST00000445824 | - | 0 | 4 | 1_367 | -81 | 60 | Domain | TTL |
| Tgene | >TTLL1 | chr5:54456071 | chr22:43455533 | ENST00000445824 | - | 0 | 4 | 181_184 | -81 | 60 | Nucleotide binding | ATP binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GPX8 | chr5:54456071 | chr22:43455533 | ENST00000503787 | + | 1 | 3 | 18_40 | -25 | 210 | Transmembrane | Helical |
| Tgene | TTLL1 | chr5:54456071 | chr22:43455533 | ENST00000266254 | - | 6 | 11 | 1_367 | 249 | 424 | Domain | TTL |
| Tgene | TTLL1 | chr5:54456071 | chr22:43455533 | ENST00000331018 | - | 6 | 10 | 1_367 | 249 | 395 | Domain | TTL |
| Tgene | TTLL1 | chr5:54456071 | chr22:43455533 | ENST00000266254 | - | 6 | 11 | 181_184 | 249 | 424 | Nucleotide binding | ATP binding |
| Tgene | TTLL1 | chr5:54456071 | chr22:43455533 | ENST00000331018 | - | 6 | 10 | 181_184 | 249 | 395 | Nucleotide binding | ATP binding |
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FusionGeneSequence for GPX8_TTLL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GPX8_ENST00000503787_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_214aa MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLES TRGKEVTSKLFDEIHWIIVQSLKAVAVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGD >In-frame_GPX8_ENST00000503787_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_243aa MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLES TRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEI >In-frame_GPX8_ENST00000296734_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_214aa MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLES TRGKEVTSKLFDEIHWIIVQSLKAVAVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGD >In-frame_GPX8_ENST00000296734_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_243aa MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLES TRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEI >In-frame_GPX8_ENST00000515370_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_163aa MEPLAAYPLKCSGPRAKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAVNASPSLTSSTANDRILKYNLINDT >In-frame_GPX8_ENST00000515370_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_192aa MEPLAAYPLKCSGPRAKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKP WLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRSR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GPX8_ENST00000503787_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_642nt ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTA ACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTTTATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTT TCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGC ACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCC CCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAA ATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGAC GGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACC >In-frame_GPX8_ENST00000503787_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_729nt ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTA ACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTTTATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTT TCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGC ACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAAC AATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGACAAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCG TCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATC CCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGG GCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACC >In-frame_GPX8_ENST00000296734_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_642nt ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTA ACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTTTATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTT TCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGC ACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCC CCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAA ATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGAC GGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACC >In-frame_GPX8_ENST00000296734_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_729nt ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTA ACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTTTATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTT TCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGC ACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAAC AATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGACAAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCG TCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATC CCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGG GCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACC >In-frame_GPX8_ENST00000515370_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_489nt ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGAGGACTACAACCACATCCATGGGGGCAAGTGGACAGTG AGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATCATCGTGCAGTCC CTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATTAATGACACC CTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTACGAGATTCTG TATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCG >In-frame_GPX8_ENST00000515370_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_576nt ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGAGGACTACAACCACATCCATGGGGGCAAGTGGACAGTG AGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATCATCGTGCAGTCC CTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGACAAGCTGAAGCCC TGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATTAATGACACCCTC AACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTACGAGATTCTGTAT GATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GPX8_ENST00000503787_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_851nt GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC ATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTG ATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAAT TACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGA GCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTG GGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTG GAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATTCATGCGGATGTATAAAACTCGCTCTTTTTTTTTTAATTTTTAACCTA >In-frame_GPX8_ENST00000503787_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_810nt GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC ATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGAC AAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATT AATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTAC GAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCA GGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTGGGC CCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTGGAA >In-frame_GPX8_ENST00000296734_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_851nt GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC ATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTG ATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAAT TACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGA GCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTG GGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTG GAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATTCATGCGGATGTATAAAACTCGCTCTTTTTTTTTTAATTTTTAACCTA >In-frame_GPX8_ENST00000296734_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_810nt GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC ATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGAC AAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATT AATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTAC GAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCA GGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTGGGC CCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTGGAA >In-frame_GPX8_ENST00000515370_chr5_54456071_+_TTLL1_ENST00000331018_chr22_43455533_-_772nt ACTTCCCTCTAGAATCCTCCAACATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGAGGACTACAACCACA TCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGA TCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCA AGTACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAG TCCTCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTC TGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACT CACTCCACCTGGGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAG GCACTTCTTTGGAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATTCATGCGGATGTATAAAACTCGCTCTTTTTTTTTTAA >In-frame_GPX8_ENST00000515370_chr5_54456071_+_TTLL1_ENST00000266254_chr22_43455533_-_731nt ACTTCCCTCTAGAATCCTCCAACATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGAGGACTACAACCACA TCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGA TCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCA TCATCGACGACAAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGT ACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCC TCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGG GGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCAC TCCACCTGGGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCA |
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FusionGenePPI for GPX8_TTLL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPX8 | GAPDHS, ERO1L, EYA2, HTR3A, CHST6, SLC39A12, PTPRO | TTLL1 | CDC27, CCT6B, ANAPC5, CDC16, HECTD1, ANAPC1, ANAPC4, DNAJB4, ANAPC16, TBC1D19, LRRC49, CDC23, TPGS2, ANAPC2, HERC1, TPGS1, C11orf49, VCPIP1, NICN1, KIAA1841 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPX8_TTLL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GPX8 | Q8TED1 | DB00143 | Glutathione | Probable glutathione peroxidase 8 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GPX8_TTLL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPX8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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