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Fusion gene ID: 15316 |
FusionGeneSummary for GPX1_SLC35B3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPX1_SLC35B3 | Fusion gene ID: 15316 | Hgene | Tgene | Gene symbol | GPX1 | SLC35B3 | Gene ID | 2876 | 51000 |
| Gene name | glutathione peroxidase 1 | solute carrier family 35 member B3 | |
| Synonyms | GPXD|GSHPX1 | C6orf196|CGI-19|PAPST2 | |
| Cytomap | 3p21.31 | 6p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutathione peroxidase 1GSHPx-1cellular glutathione peroxidase | adenosine 3'-phospho 5'-phosphosulfate transporter 23' phosphoadenosine 5' phosphosulfate transporter 2PAPS transporter 2solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P07203 | Q9H1N7 | |
| Ensembl transtripts involved in fusion gene | ENST00000419783, ENST00000419349, ENST00000496791, | ENST00000379660, ENST00000339306, ENST00000426876, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GPX1 [Title/Abstract] AND SLC35B3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPX1 | GO:0006749 | glutathione metabolic process | 12829378 |
| Hgene | GPX1 | GO:0040029 | regulation of gene expression, epigenetic | 16132718 |
| Hgene | GPX1 | GO:0042744 | hydrogen peroxide catabolic process | 15203190 |
| Hgene | GPX1 | GO:0045454 | cell redox homeostasis | 12829378 |
| Hgene | GPX1 | GO:0061136 | regulation of proteasomal protein catabolic process | 12751788 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA995621 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000419783 | ENST00000379660 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-intron | ENST00000419783 | ENST00000339306 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-intron | ENST00000419783 | ENST00000426876 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-5UTR | ENST00000419349 | ENST00000379660 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-intron | ENST00000419349 | ENST00000339306 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-intron | ENST00000419349 | ENST00000426876 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-5UTR | ENST00000496791 | ENST00000379660 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-intron | ENST00000496791 | ENST00000339306 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
| intron-intron | ENST00000496791 | ENST00000426876 | GPX1 | chr3 | 49394752 | + | SLC35B3 | chr6 | 8435434 | + |
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FusionProtFeatures for GPX1_SLC35B3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPX1 | SLC35B3 |
| Protects the hemoglobin in erythrocytes from oxidativebreakdown. | Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is auniversal sulfuryl donor for sulfation events that take place inthe Golgi. Compensates for the insufficient expression ofSLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates inthe colon. {ECO:0000269|PubMed:16492677}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPX1_SLC35B3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPX1_SLC35B3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPX1_SLC35B3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GPX1 | P07203 | DB00143 | Glutathione | Glutathione peroxidase 1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GPX1_SLC35B3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPX1 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | GPX1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | CTD_human |
| Hgene | GPX1 | C0020459 | Hyperinsulinism | 2 | CTD_human |
| Hgene | GPX1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | GPX1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | GPX1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | GPX1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | GPX1 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
| Hgene | GPX1 | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Hgene | GPX1 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Hgene | GPX1 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | GPX1 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | GPX1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | GPX1 | C0014544 | Epilepsy | 1 | CTD_human |
| Hgene | GPX1 | C0015695 | Fatty Liver | 1 | CTD_human |
| Hgene | GPX1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Hgene | GPX1 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| Hgene | GPX1 | C0020456 | Hyperglycemia | 1 | CTD_human |
| Hgene | GPX1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | GPX1 | C0020550 | Hyperthyroidism | 1 | CTD_human |
| Hgene | GPX1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | GPX1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | GPX1 | C0029456 | Osteoporosis | 1 | CTD_human |
| Hgene | GPX1 | C0030567 | Parkinson Disease | 1 | CTD_human |
| Hgene | GPX1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | GPX1 | C0036351 | Residual schizophrenia | 1 | PSYGENET |
| Hgene | GPX1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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