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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15315

FusionGeneSummary for GPX1_RPL3

check button Fusion gene summary
Fusion gene informationFusion gene name: GPX1_RPL3
Fusion gene ID: 15315
HgeneTgene
Gene symbol

GPX1

RPL3

Gene ID

2876

6122

Gene nameglutathione peroxidase 1ribosomal protein L3
SynonymsGPXD|GSHPX1ASC-1|L3|TARBP-B
Cytomap

3p21.31

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionglutathione peroxidase 1GSHPx-1cellular glutathione peroxidase60S ribosomal protein L3HIV-1 TAR RNA-binding protein Blarge ribosomal subunit protein uL3
Modification date2018052720180523
UniProtAcc

P07203

P39023

Ensembl transtripts involved in fusion geneENST00000419783, ENST00000419349, 
ENST00000496791, 
ENST00000216146, 
ENST00000465618, ENST00000401609, 
Fusion gene scores* DoF score2 X 2 X 1=411 X 9 X 3=297
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/297*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPX1 [Title/Abstract] AND RPL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPX1

GO:0006749

glutathione metabolic process

12829378

HgeneGPX1

GO:0040029

regulation of gene expression, epigenetic

16132718

HgeneGPX1

GO:0042744

hydrogen peroxide catabolic process

15203190

HgeneGPX1

GO:0045454

cell redox homeostasis

12829378

HgeneGPX1

GO:0061136

regulation of proteasomal protein catabolic process

12751788


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP429026GPX1chr3

49394925

-RPL3chr22

39710177

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000419783ENST00000216146GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-5UTRENST00000419783ENST00000465618GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-5UTRENST00000419783ENST00000401609GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-3CDSENST00000419349ENST00000216146GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-5UTRENST00000419349ENST00000465618GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-5UTRENST00000419349ENST00000401609GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-3CDSENST00000496791ENST00000216146GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-5UTRENST00000496791ENST00000465618GPX1chr3

49394925

-RPL3chr22

39710177

-
intron-5UTRENST00000496791ENST00000401609GPX1chr3

49394925

-RPL3chr22

39710177

-

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FusionProtFeatures for GPX1_RPL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPX1

P07203

RPL3

P39023

Protects the hemoglobin in erythrocytes from oxidativebreakdown. The L3 protein is a component of the large subunit ofcytoplasmic ribosomes. {ECO:0000305|PubMed:12962325}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPX1_RPL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPX1_RPL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPX1_RPL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPX1P07203DB00143GlutathioneGlutathione peroxidase 1small moleculeapproved|investigational|nutraceutical
TgeneRPL3P39023DB04865Omacetaxine mepesuccinate60S ribosomal protein L3small moleculeapproved|investigational
TgeneRPL3P39023DB09092Xanthinol60S ribosomal protein L3small moleculeapproved|withdrawn

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RelatedDiseases for GPX1_RPL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPX1C0036341Schizophrenia3PSYGENET
HgeneGPX1C0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
HgeneGPX1C0020459Hyperinsulinism2CTD_human
HgeneGPX1C0004352Autistic Disorder1CTD_human
HgeneGPX1C0005695Bladder Neoplasm1CTD_human
HgeneGPX1C0007137Squamous cell carcinoma1CTD_human
HgeneGPX1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneGPX1C0007193Cardiomyopathy, Dilated1CTD_human
HgeneGPX1C0007222Cardiovascular Diseases1CTD_human
HgeneGPX1C0007786Brain Ischemia1CTD_human
HgeneGPX1C0011570Mental Depression1PSYGENET
HgeneGPX1C0011581Depressive disorder1PSYGENET
HgeneGPX1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneGPX1C0014544Epilepsy1CTD_human
HgeneGPX1C0015695Fatty Liver1CTD_human
HgeneGPX1C0018671Head and Neck Neoplasms1CTD_human
HgeneGPX1C0019189Hepatitis, Chronic1CTD_human
HgeneGPX1C0020456Hyperglycemia1CTD_human
HgeneGPX1C0020538Hypertensive disease1CTD_human
HgeneGPX1C0020550Hyperthyroidism1CTD_human
HgeneGPX1C0024121Lung Neoplasms1CTD_human
HgeneGPX1C0028754Obesity1CTD_human
HgeneGPX1C0029456Osteoporosis1CTD_human
HgeneGPX1C0030567Parkinson Disease1CTD_human
HgeneGPX1C0035126Reperfusion Injury1CTD_human
HgeneGPX1C0036351Residual schizophrenia1PSYGENET
HgeneGPX1C1458155Mammary Neoplasms1CTD_human
TgeneRPL3C0024667Animal Mammary Neoplasms1CTD_human
TgeneRPL3C0024668Mammary Neoplasms, Experimental1CTD_human