FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15313

FusionGeneSummary for GPT2_FNBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPT2_FNBP1
Fusion gene ID: 15313
HgeneTgene
Gene symbol

GPT2

FNBP1

Gene ID

84706

23048

Gene nameglutamic--pyruvic transaminase 2formin binding protein 1
SynonymsALT2|GPT 2|MRT49FBP17
Cytomap

16q11.2

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionalanine aminotransferase 2glutamate pyruvate transaminase 2glutamic pyruvate transaminase (alanine aminotransferase) 2glutamic pyruvate transaminase 2glutamic--alanine transaminase 2formin-binding protein 1formin-binding protein 17
Modification date2018051920180529
UniProtAcc

Q8TD30

Q96RU3

Ensembl transtripts involved in fusion geneENST00000340124, ENST00000440783, 
ENST00000446176, ENST00000420781, 
ENST00000355681, ENST00000443566, 
ENST00000478129, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 10 X 3=240
# samples 214
** MAII scorelog2(2/8*10)=1.32192809488736log2(14/240*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPT2 [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPT2

GO:0006103

2-oxoglutarate metabolic process

11863375

HgeneGPT2

GO:0042851

L-alanine metabolic process

11863375


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA449487GPT2chr16

46965083

-FNBP1chr9

132651026

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000340124ENST00000446176GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-3UTRENST00000340124ENST00000420781GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-intronENST00000340124ENST00000355681GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-intronENST00000340124ENST00000443566GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-intronENST00000340124ENST00000478129GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-3UTRENST00000440783ENST00000446176GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-3UTRENST00000440783ENST00000420781GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-intronENST00000440783ENST00000355681GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-intronENST00000440783ENST00000443566GPT2chr16

46965083

-FNBP1chr9

132651026

+
3UTR-intronENST00000440783ENST00000478129GPT2chr16

46965083

-FNBP1chr9

132651026

+

Top

FusionProtFeatures for GPT2_FNBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPT2

Q8TD30

FNBP1

Q96RU3

Catalyzes the reversible transamination between alanineand 2-oxoglutarate to form pyruvate and glutamate.{ECO:0000269|PubMed:11863375}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GPT2_FNBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GPT2_FNBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GPT2_FNBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPT2Q8TD30DB00780PhenelzineAlanine aminotransferase 2small moleculeapproved
HgeneGPT2Q8TD30DB00114Pyridoxal PhosphateAlanine aminotransferase 2small moleculeapproved|investigational|nutraceutical
HgeneGPT2Q8TD30DB00142Glutamic AcidAlanine aminotransferase 2small moleculeapproved|nutraceutical

Top

RelatedDiseases for GPT2_FNBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPT2C4225388MENTAL RETARDATION, AUTOSOMAL RECESSIVE 491UNIPROT