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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15310

FusionGeneSummary for GPS1_STRA13

check button Fusion gene summary
Fusion gene informationFusion gene name: GPS1_STRA13
Fusion gene ID: 15310
HgeneTgene
Gene symbol

GPS1

STRA13

Gene ID

2873

201254

Gene nameG protein pathway suppressor 1centromere protein X
SynonymsCOPS1|CSN1|SGN1CENP-X|D9|FAAP10|MHF2|STRA13
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionCOP9 signalosome complex subunit 1JAB1-containing signalosome subunit 1centromere protein XFANCM associated histone fold protein 2FANCM-interacting histone fold protein 2Fanconi anemia-associated polypeptide of 10 kDaretinoic acid-inducible gene D9 protein homologstimulated by retinoic acid 13 homologstimulated by reti
Modification date2018052320180523
UniProtAcc

Q13098

Ensembl transtripts involved in fusion geneENST00000583983, ENST00000578552, 
ENST00000320548, ENST00000355130, 
ENST00000306823, ENST00000392358, 
ENST00000580435, ENST00000392359, 
ENST00000306704, ENST00000584347, 
ENST00000583767, 
Fusion gene scores* DoF score2 X 1 X 1=21 X 1 X 1=1
# samples 11
** MAII scorelog2(1/2*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: GPS1 [Title/Abstract] AND STRA13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPS1

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AJ-A3BF-01AGPS1chr17

80009840

+STRA13chr17

79977785

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000583983ENST00000580435GPS1chr17

80009840

+STRA13chr17

79977785

-
intron-3CDSENST00000583983ENST00000392359GPS1chr17

80009840

+STRA13chr17

79977785

-
intron-3CDSENST00000583983ENST00000306704GPS1chr17

80009840

+STRA13chr17

79977785

-
intron-3CDSENST00000583983ENST00000584347GPS1chr17

80009840

+STRA13chr17

79977785

-
intron-5UTRENST00000583983ENST00000583767GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000578552ENST00000580435GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000578552ENST00000392359GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000578552ENST00000306704GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000578552ENST00000584347GPS1chr17

80009840

+STRA13chr17

79977785

-
5CDS-5UTRENST00000578552ENST00000583767GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000320548ENST00000580435GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000320548ENST00000392359GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000320548ENST00000306704GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000320548ENST00000584347GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-5UTRENST00000320548ENST00000583767GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000355130ENST00000580435GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000355130ENST00000392359GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000355130ENST00000306704GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000355130ENST00000584347GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-5UTRENST00000355130ENST00000583767GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000306823ENST00000580435GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000306823ENST00000392359GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000306823ENST00000306704GPS1chr17

80009840

+STRA13chr17

79977785

-
In-frameENST00000306823ENST00000584347GPS1chr17

80009840

+STRA13chr17

79977785

-
5CDS-5UTRENST00000306823ENST00000583767GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000392358ENST00000580435GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000392358ENST00000392359GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000392358ENST00000306704GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-3CDSENST00000392358ENST00000584347GPS1chr17

80009840

+STRA13chr17

79977785

-
5UTR-5UTRENST00000392358ENST00000583767GPS1chr17

80009840

+STRA13chr17

79977785

-

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FusionProtFeatures for GPS1_STRA13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPS1

Q13098

STRA13

Essential component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmentalprocesses. The CSN complex is an essential regulator of theubiquitin (Ubl) conjugation pathway by mediating the deneddylationof the cullin subunits of SCF-type E3 ligase complexes, leading todecrease the Ubl ligase activity of SCF-type complexes such asSCF, CSA or DDB2. The complex is also involved in phosphorylationof p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP,possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protectsdegradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signaltransduction. {ECO:0000269|PubMed:11285227,ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923,ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPS1_STRA13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPS1_STRA13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPS1WRAP73, COPS8, COPS5, COPS6, DDB1, COPS3, CUL1, MALT1, CARD11, IRF5, IRF8, COPS2, COPS4, COPS7B, NF2, CUL4A, PSMA6, POLR2A, TP53, DDB2, ERCC8, ASB4, CUL3, CUL4B, CUL5, CUL2, DCUN1D1, NEDD8, NOD1, ITPK1, GFER, COPS7A, NOTCH1, SENP8, FBXW4, NFKBIA, FBXO6, PRKAR2A, IP6K1, SKP1, SKP2, RBX1, RELA, USP48, MAGEA1, AMBRA1, CLIP1, NTRK1, SAP130, CPSF1, FGFR1OP, MYEOV2, MAPK8, APBB3, DCAF4, KLHL10, BTBD1, FBXL14, DET1, DCAF11, FBXO7, UBE2M, PTPN14, USH1C, DCAF4L2STRA13FANCM, APITD1, FANCL, FANCA, FANCG, MDM2, NKX3-1, BLM, C17orf70, RMI1, RPA1, FANCE, FANCC, FANCF, RPA2, C19orf40, REL, TRIM54, CENPQ, CENPO, CNTROB, CENPU


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPS1_STRA13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPS1_STRA13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPS1C0036341Schizophrenia1PSYGENET