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Fusion gene ID: 15300 |
FusionGeneSummary for GPRC5A_XRN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPRC5A_XRN2 | Fusion gene ID: 15300 | Hgene | Tgene | Gene symbol | GPRC5A | XRN2 | Gene ID | 9052 | 22803 |
| Gene name | G protein-coupled receptor class C group 5 member A | 5'-3' exoribonuclease 2 | |
| Synonyms | GPCR5A|PEIG-1|RAI3|RAIG1|TIG1 | - | |
| Cytomap | 12p13.1 | 20p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | retinoic acid-induced protein 3G-protein coupled receptor family C group 5 member ATPA induced gene 1orphan G-protein-coupling receptor PEIG-1phorbol ester induced gene 1phorbol ester induced protein-1retinoic acid induced 3retinoic acid responsive | 5'-3' exoribonuclease 2DHP proteinDhm1-like protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q8NFJ5 | Q9H0D6 | |
| Ensembl transtripts involved in fusion gene | ENST00000014914, ENST00000542056, | ENST00000377191, ENST00000430571, ENST00000539513, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 1=16 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GPRC5A [Title/Abstract] AND XRN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | XRN2 | GO:0000738 | DNA catabolic process, exonucleolytic | 15565158 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI917076 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000014914 | ENST00000377191 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| 3UTR-intron | ENST00000014914 | ENST00000430571 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| 3UTR-intron | ENST00000014914 | ENST00000539513 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| intron-intron | ENST00000542056 | ENST00000377191 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| intron-intron | ENST00000542056 | ENST00000430571 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| intron-intron | ENST00000542056 | ENST00000539513 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
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FusionProtFeatures for GPRC5A_XRN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPRC5A | XRN2 |
| Orphan receptor. Could be involved in modulatingdifferentiation and maintaining homeostasis of epithelial cells.This retinoic acid-inducible GPCR provide evidence for a possibleinteraction between retinoid and G-protein signaling pathways.Functions as a negative modulator of EGFR signaling (Bysimilarity). May act as a lung tumor suppressor (PubMed:18000218).{ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}. | Possesses 5'->3' exoribonuclease activity (Bysimilarity). May promote the termination of transcription by RNApolymerase II. During transcription termination, cleavage at thepolyadenylation site liberates a 5' fragment which is subsequentlyprocessed to form the mature mRNA and a 3' fragment which remainsattached to the elongating polymerase. The processive degradationof this 3' fragment by this protein may promote termination oftranscription. Binds to RNA polymerase II (RNAp II) transcriptiontermination R-loops formed by G-rich pause sites(PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158,ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPRC5A_XRN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPRC5A_XRN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPRC5A_XRN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GPRC5A | Q8NFJ5 | DB00755 | Tretinoin | Retinoic acid-induced protein 3 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GPRC5A_XRN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPRC5A | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
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