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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15298

FusionGeneSummary for GPRC5A_DSP

check button Fusion gene summary
Fusion gene informationFusion gene name: GPRC5A_DSP
Fusion gene ID: 15298
HgeneTgene
Gene symbol

GPRC5A

DSP

Gene ID

9052

1832

Gene nameG protein-coupled receptor class C group 5 member Adesmoplakin
SynonymsGPCR5A|PEIG-1|RAI3|RAIG1|TIG1DCWHKTA|DP
Cytomap

12p13.1

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionretinoic acid-induced protein 3G-protein coupled receptor family C group 5 member ATPA induced gene 1orphan G-protein-coupling receptor PEIG-1phorbol ester induced gene 1phorbol ester induced protein-1retinoic acid induced 3retinoic acid responsivedesmoplakin250/210 kDa paraneoplastic pemphigus antigen
Modification date2018052220180523
UniProtAcc

Q8NFJ5

P15924

Ensembl transtripts involved in fusion geneENST00000014914, ENST00000542056, 
ENST00000379802, ENST00000418664, 
Fusion gene scores* DoF score4 X 4 X 2=3217 X 15 X 8=2040
# samples 422
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(22/2040*10)=-3.2129937233342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPRC5A [Title/Abstract] AND DSP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDSP

GO:0018149

peptide cross-linking

10908733

TgeneDSP

GO:0030216

keratinocyte differentiation

10908733


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE706031GPRC5Achr12

13061511

+DSPchr6

7585640

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000014914ENST00000379802GPRC5Achr12

13061511

+DSPchr6

7585640

-
Frame-shiftENST00000014914ENST00000418664GPRC5Achr12

13061511

+DSPchr6

7585640

-
intron-3CDSENST00000542056ENST00000379802GPRC5Achr12

13061511

+DSPchr6

7585640

-
intron-3CDSENST00000542056ENST00000418664GPRC5Achr12

13061511

+DSPchr6

7585640

-

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FusionProtFeatures for GPRC5A_DSP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPRC5A

Q8NFJ5

DSP

P15924

Orphan receptor. Could be involved in modulatingdifferentiation and maintaining homeostasis of epithelial cells.This retinoic acid-inducible GPCR provide evidence for a possibleinteraction between retinoid and G-protein signaling pathways.Functions as a negative modulator of EGFR signaling (Bysimilarity). May act as a lung tumor suppressor (PubMed:18000218).{ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}. Major high molecular weight protein of desmosomes.Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and inthe anchoring of intermediate filaments to the desmosomes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0241018_1945-1142872Coiled coilOntology_term=ECO:0000255
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0241018_1945-1002273Coiled coilOntology_term=ECO:0000255
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024458_515-1142872DomainSH3
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024458_515-1002273DomainSH3
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0241057_1945-1142872RegionNote=Central fibrous rod domain
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0241946_2871-1142872RegionNote=Globular 2
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0241960_2208-1142872RegionNote=4.5 X 38 AA tandem repeats (Domain A)
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0241_1056-1142872RegionNote=Globular 1
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242244_2446-1142872RegionNote=4.5 X 38 AA tandem repeats (Domain B)
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242609_2822-1142872RegionNote=4.5 X 38 AA tandem repeats (Domain C)
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242824_2847-1142872RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0241057_1945-1002273RegionNote=Central fibrous rod domain
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0241946_2871-1002273RegionNote=Globular 2
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0241960_2208-1002273RegionNote=4.5 X 38 AA tandem repeats (Domain A)
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0241_1056-1002273RegionNote=Globular 1
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242244_2446-1002273RegionNote=4.5 X 38 AA tandem repeats (Domain B)
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242609_2822-1002273RegionNote=4.5 X 38 AA tandem repeats (Domain C)
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242824_2847-1002273RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024178_271-1142872RepeatNote=Spectrin 1
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242009_2045-1142872RepeatNote=Plectin 1
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242046_2083-1142872RepeatNote=Plectin 2
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242084_2121-1142872RepeatNote=Plectin 3
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242122_2159-1142872RepeatNote=Plectin 4
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242163_2197-1142872RepeatNote=Plectin 5
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242198_2233-1142872RepeatNote=Plectin 6
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242251_2288-1142872RepeatNote=Plectin 7
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242289_2326-1142872RepeatNote=Plectin 8
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242327_2364-1142872RepeatNote=Plectin 9
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242365_2402-1142872RepeatNote=Plectin 10
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242406_2440-1142872RepeatNote=Plectin 11
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242456_2493-1142872RepeatNote=Plectin 12
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242507_2544-1142872RepeatNote=Plectin 13
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242610_2647-1142872RepeatNote=Plectin 14
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242648_2685-1142872RepeatNote=Plectin 15
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242724_2761-1142872RepeatNote=Plectin 16
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024272_375-1142872RepeatNote=Spectrin 2
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0242762_2799-1142872RepeatNote=Plectin 17
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024376_446-1142872RepeatNote=Spectrin 3a
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024516_545-1142872RepeatNote=Spectrin 3b
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024546_627-1142872RepeatNote=Spectrin 4
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024654_769-1142872RepeatNote=Spectrin 5
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+024770_883-1142872RepeatNote=Spectrin 6
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024178_271-1002273RepeatNote=Spectrin 1
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242009_2045-1002273RepeatNote=Plectin 1
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242046_2083-1002273RepeatNote=Plectin 2
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242084_2121-1002273RepeatNote=Plectin 3
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242122_2159-1002273RepeatNote=Plectin 4
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242163_2197-1002273RepeatNote=Plectin 5
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242198_2233-1002273RepeatNote=Plectin 6
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242251_2288-1002273RepeatNote=Plectin 7
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242289_2326-1002273RepeatNote=Plectin 8
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242327_2364-1002273RepeatNote=Plectin 9
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242365_2402-1002273RepeatNote=Plectin 10
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242406_2440-1002273RepeatNote=Plectin 11
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242456_2493-1002273RepeatNote=Plectin 12
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242507_2544-1002273RepeatNote=Plectin 13
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242610_2647-1002273RepeatNote=Plectin 14
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242648_2685-1002273RepeatNote=Plectin 15
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242724_2761-1002273RepeatNote=Plectin 16
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024272_375-1002273RepeatNote=Spectrin 2
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0242762_2799-1002273RepeatNote=Plectin 17
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024376_446-1002273RepeatNote=Spectrin 3a
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024516_545-1002273RepeatNote=Spectrin 3b
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024546_627-1002273RepeatNote=Spectrin 4
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024654_769-1002273RepeatNote=Spectrin 5
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+024770_883-1002273RepeatNote=Spectrin 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPRC5A_DSP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GPRC5A_ENST00000014914_chr12_13061511_+_DSP_ENST00000379802_chr6_7585640_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GPRC5A_ENST00000014914_chr12_13061511_+_DSP_ENST00000379802_chr6_7585640_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_GPRC5A_ENST00000014914_chr12_13061511_+_DSP_ENST00000379802_chr6_7585640_-_0nt


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FusionGenePPI for GPRC5A_DSP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDSPchr12:13061511chr6:7585640ENST00000379802+0241_584-1142872plakophilin 1 and junction plakoglobin
TgeneDSPchr12:13061511chr6:7585640ENST00000418664+0241_584-1002273plakophilin 1 and junction plakoglobin


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPRC5A_DSP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPRC5AQ8NFJ5DB00755TretinoinRetinoic acid-induced protein 3small moleculeapproved|investigational|nutraceutical
TgeneDSPP15924DB01593ZincDesmoplakinsmall moleculeapproved|investigational
TgeneDSPP15924DB11638ArtenimolDesmoplakinsmall moleculeapproved|investigational

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RelatedDiseases for GPRC5A_DSP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPRC5AC0003873Rheumatoid Arthritis1CTD_human
TgeneDSPC1843896Arrhythmogenic Right Ventricular Dysplasia, Familial, 83CTD_human;UNIPROT
TgeneDSPC4014393CARDIOMYOPATHY, DILATED, WITH WOOLLY HAIR, KERATODERMA, AND TOOTH AGENESIS2UNIPROT
TgeneDSPC0085298Sudden Cardiac Death1CTD_human;HPO
TgeneDSPC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
TgeneDSPC1843292Skin Fragility-Woolly Hair Syndrome1CTD_human;ORPHANET;UNIPROT
TgeneDSPC1854063Cardiomyopathy dilated with Woolly hair and keratoderma1CTD_human;ORPHANET