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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15284

FusionGeneSummary for GPR37L1_PLXNB3

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR37L1_PLXNB3
Fusion gene ID: 15284
HgeneTgene
Gene symbol

GPR37L1

PLXNB3

Gene ID

9283

5365

Gene nameG protein-coupled receptor 37 like 1plexin B3
SynonymsET(B)R-LP-2|ETBR-LP-2|ETBRLP2PLEXB3|PLEXR|PLXN6
Cytomap

1q32.1

Xq28

Type of geneprotein-codingprotein-coding
Descriptionprosaposin receptor GPR37L1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2plexin-B3plexin 6
Modification date2018052020180523
UniProtAcc

O60883

Q9ULL4

Ensembl transtripts involved in fusion geneENST00000367282, ENST00000538966, 
ENST00000361971, ENST00000538543, 
ENST00000538776, ENST00000538282, 
ENST00000485980, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 1=9
# samples 34
** MAII scorelog2(3/8*10)=1.90689059560852log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPR37L1 [Title/Abstract] AND PLXNB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPR37L1

GO:0007193

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

23690594

HgeneGPR37L1

GO:0043410

positive regulation of MAPK cascade

23690594

TgenePLXNB3

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

16122393

TgenePLXNB3

GO:0007162

negative regulation of cell adhesion

15218527

TgenePLXNB3

GO:0010976

positive regulation of neuron projection development

16122393

TgenePLXNB3

GO:0050918

positive chemotaxis

15218527

TgenePLXNB3

GO:0060326

cell chemotaxis

15218527

TgenePLXNB3

GO:0071526

semaphorin-plexin signaling pathway

15218527


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI884619GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
ChiTaRS3.1AI886978GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000367282ENST00000538966GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
3UTR-3CDSENST00000367282ENST00000361971GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
3UTR-intronENST00000367282ENST00000538543GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
3UTR-intronENST00000367282ENST00000538776GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
3UTR-intronENST00000367282ENST00000538282GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-
3UTR-3UTRENST00000367282ENST00000485980GPR37L1chr1

202098509

-PLXNB3chrX

153043121

-

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FusionProtFeatures for GPR37L1_PLXNB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR37L1

O60883

PLXNB3

Q9ULL4

Receptor for the neuroprotective and glioprotectivefactor prosaposin. Ligand binding induces endocytosis, followed byan ERK phosphorylation cascade. {ECO:0000269|PubMed:23690594}. Receptor for SEMA5A that plays a role in axon guidance,invasive growth and cell migration. Stimulates neurite outgrowthand mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In gliomacells, SEMA5A stimulation of PLXNB3 results in the disassembly ofF-actin stress fibers, disruption of focal adhesions and cellularcollapse as well as inhibition of cell migration and invasionthrough ARHGDIA-mediated inactivation of RAC1.{ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765,ECO:0000269|PubMed:21706053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPR37L1_PLXNB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPR37L1_PLXNB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPR37L1_PLXNB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPR37L1_PLXNB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource