|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 15246 |
FusionGeneSummary for GPR108_PDE4A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPR108_PDE4A | Fusion gene ID: 15246 | Hgene | Tgene | Gene symbol | GPR108 | PDE4A | Gene ID | 56927 | 5141 |
| Gene name | G protein-coupled receptor 108 | phosphodiesterase 4A | |
| Synonyms | LUSTR2 | DPDE2|PDE4|PDE46 | |
| Cytomap | 19p13.3 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein GPR108lung seven transmembrane receptor 2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4Aphosphodiesterase 4A, cAMP-specific (duncephosphodiesterase E2 dunce homolog, Drosophilaphosphodiesterase isozyme 4 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NPR9 | P27815 | |
| Ensembl transtripts involved in fusion gene | ENST00000264080, ENST00000598626, ENST00000430424, | ENST00000592685, ENST00000380702, ENST00000352831, ENST00000293683, ENST00000440014, ENST00000344979, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 3 X 6=72 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPR108 [Title/Abstract] AND PDE4A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDE4A | GO:0006198 | cAMP catabolic process | 17404263 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA432285 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000264080 | ENST00000592685 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000264080 | ENST00000380702 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000264080 | ENST00000352831 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000264080 | ENST00000293683 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000264080 | ENST00000440014 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000264080 | ENST00000344979 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000598626 | ENST00000592685 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000598626 | ENST00000380702 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000598626 | ENST00000352831 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000598626 | ENST00000293683 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000598626 | ENST00000440014 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000598626 | ENST00000344979 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000430424 | ENST00000592685 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000430424 | ENST00000380702 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000430424 | ENST00000352831 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000430424 | ENST00000293683 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-intron | ENST00000430424 | ENST00000440014 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
| intron-3UTR | ENST00000430424 | ENST00000344979 | GPR108 | chr19 | 6733130 | - | PDE4A | chr19 | 10578350 | + |
Top |
FusionProtFeatures for GPR108_PDE4A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPR108 | PDE4A |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for GPR108_PDE4A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for GPR108_PDE4A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GPR108_PDE4A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PDE4A | P27815 | DB00277 | Theophylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Tgene | PDE4A | P27815 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Tgene | PDE4A | P27815 | DB00975 | Dipyridamole | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Tgene | PDE4A | P27815 | DB01303 | Oxtriphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Tgene | PDE4A | P27815 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Tgene | PDE4A | P27815 | DB08811 | Tofisopam | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Tgene | PDE4A | P27815 | DB00806 | Pentoxifylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Tgene | PDE4A | P27815 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Tgene | PDE4A | P27815 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Tgene | PDE4A | P27815 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Tgene | PDE4A | P27815 | DB06751 | Drotaverine | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
Top |
RelatedDiseases for GPR108_PDE4A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PDE4A | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | PDE4A | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | PDE4A | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | PDE4A | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | PDE4A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | PDE4A | C0085159 | Seasonal Affective Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|