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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15215

FusionGeneSummary for GPI_MYH11

check button Fusion gene summary
Fusion gene informationFusion gene name: GPI_MYH11
Fusion gene ID: 15215
HgeneTgene
Gene symbol

GPI

MYH11

Gene ID

10007

4629

Gene nameglucosamine-6-phosphate deaminase 1myosin heavy chain 11
SynonymsGNP1|GNPDA|GNPI|GPI|HLNAAT4|FAA4|SMHC|SMMHC
Cytomap

5q31.3

16p13.11

Type of geneprotein-codingprotein-coding
Descriptionglucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillinmyosin-11myosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle
Modification date2018052320180519
UniProtAcc

P06744

P35749

Ensembl transtripts involved in fusion geneENST00000415930, ENST00000356487, 
ENST00000586425, 
ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000300036, ENST00000573908, 
Fusion gene scores* DoF score13 X 13 X 5=84511 X 15 X 6=990
# samples 1321
** MAII scorelog2(13/845*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/990*10)=-2.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPI [Title/Abstract] AND MYH11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF358813GPIchr19

34877899

+MYH11chr16

15898010

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000415930ENST00000396324GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000415930ENST00000452625GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000415930ENST00000576790GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000415930ENST00000300036GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000415930ENST00000573908GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000356487ENST00000396324GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000356487ENST00000452625GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000356487ENST00000576790GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000356487ENST00000300036GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000356487ENST00000573908GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000586425ENST00000396324GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000586425ENST00000452625GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000586425ENST00000576790GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000586425ENST00000300036GPIchr19

34877899

+MYH11chr16

15898010

-
intron-intronENST00000586425ENST00000573908GPIchr19

34877899

+MYH11chr16

15898010

-

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FusionProtFeatures for GPI_MYH11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPI

P06744

MYH11

P35749

Besides it's role as a glycolytic enzyme, mammalian GPIcan function as a tumor-secreted cytokine and an angiogenic factor(AMF) that stimulates endothelial cell motility. GPI is also aneurotrophic factor (Neuroleukin) for spinal and sensory neurons.{ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}. Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPI_MYH11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPI_MYH11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPI_MYH11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPIP06744DB11638ArtenimolGlucose-6-phosphate isomerasesmall moleculeapproved|investigational

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RelatedDiseases for GPI_MYH11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPIC3150730HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO GLUCOSE PHOSPHATE ISOMERASE DEFICIENCY6CTD_human;ORPHANET;UNIPROT
HgeneGPIC0002878Anemia, Hemolytic1CTD_human
HgeneGPIC1458155Mammary Neoplasms1CTD_human
TgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneMYH11C0023479Acute myelomonocytic leukemia1CTD_human;ORPHANET
TgeneMYH11C1851504Aortic aneurysm, familial thoracic 41CTD_human;UNIPROT