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Fusion gene ID: 15181 |
FusionGeneSummary for GPC5_CMBL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPC5_CMBL | Fusion gene ID: 15181 | Hgene | Tgene | Gene symbol | GPC5 | CMBL | Gene ID | 2262 | 134147 |
| Gene name | glypican 5 | carboxymethylenebutenolidase homolog | |
| Synonyms | - | JS-1 | |
| Cytomap | 13q31.3 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glypican-5bA93M14.1glypican proteoglycan 5 | carboxymethylenebutenolidase homologcarboxymethylenebutenolidase homolog (Pseudomonas)carboxymethylenebutenolidase-like (Pseudomonas) | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P78333 | Q96DG6 | |
| Ensembl transtripts involved in fusion gene | ENST00000377067, ENST00000483422, | ENST00000296658, ENST00000510532, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 3 X 2=24 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GPC5 [Title/Abstract] AND CMBL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-G5-6233-01A | GPC5 | chr13 | 92797242 | + | CMBL | chr5 | 10282400 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377067 | ENST00000296658 | GPC5 | chr13 | 92797242 | + | CMBL | chr5 | 10282400 | - |
| 5CDS-intron | ENST00000377067 | ENST00000510532 | GPC5 | chr13 | 92797242 | + | CMBL | chr5 | 10282400 | - |
| intron-3CDS | ENST00000483422 | ENST00000296658 | GPC5 | chr13 | 92797242 | + | CMBL | chr5 | 10282400 | - |
| intron-intron | ENST00000483422 | ENST00000510532 | GPC5 | chr13 | 92797242 | + | CMBL | chr5 | 10282400 | - |
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FusionProtFeatures for GPC5_CMBL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPC5 | CMBL |
| Cell surface proteoglycan that bears heparan sulfate.{ECO:0000250}. | Cysteine hydrolase. Can convert the prodrug olmesartanmedoxomil into its pharmacologically active metaboliteolmerstatan, an angiotensin receptor blocker, in liver andintestine. May also activate beta-lactam antibiotics faropenemmedoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPC5_CMBL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GPC5_ENST00000377067_chr13_92797242_+_CMBL_ENST00000296658_chr5_10282400_-_611aa MDAQTWPVGFRCLLLLALVGSARSEGVQTCEEVRKLFQWRLLGAVRGLPDSPRAGPDLQVCISKKPTCCTRKMEERYQIAARQDMQQFLQ TSSSTLKFLISRNAAAFQETLETLIKQAENYTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLIN PGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTDYLHFSKECSRALLKMQYCPHCQGLALTKPC MGYCLNVMRGCLAHMAELNPHWHAYIRSLEELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSF DQSKEKHGMKTTTRNSEETLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWNGEDIVKSYTQRVVGNGIKAQSGNPEVKVKG IDPVINQIIDKLKHVVQLLQGRSPKPDKWELLQLGSGGGMVEQVSGDCDDEDGCGGSGSGEVKRTLKITDCIVKDSEDIYNLKNPTLFIF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GPC5_ENST00000377067_chr13_92797242_+_CMBL_ENST00000296658_chr5_10282400_-_1833nt ATGGACGCACAGACCTGGCCCGTGGGCTTTCGCTGCCTCCTCCTTCTGGCCCTGGTTGGGTCCGCCCGCAGCGAGGGCGTGCAGACCTGC GAAGAAGTTCGGAAACTTTTCCAGTGGCGGCTGCTGGGAGCTGTCAGGGGGCTGCCGGATTCGCCGCGGGCAGGACCTGATCTTCAGGTT TGCATATCCAAAAAGCCTACATGTTGCACCAGGAAGATGGAGGAGAGATATCAGATTGCGGCTCGCCAGGATATGCAGCAGTTTCTTCAA ACGTCCAGCTCTACATTAAAGTTTCTAATATCTCGAAATGCGGCTGCTTTTCAAGAAACCCTTGAAACTCTCATCAAACAAGCAGAAAAT TACACCAGTATACTTTTTTGCAGTACCTACAGGAACATGGCCTTGGAGGCTGCTGCTTCGGTTCAGGAGTTCTTCACTGATGTGGGGCTG TATTTATTTGGTGCGGATGTTAATCCTGAAGAATTTGTAAACAGATTTTTTGACAGTCTTTTTCCTCTGGTCTACAACCACCTCATTAAC CCTGGTGTGACTGACAGTTCCCTGGAATACTCAGAATGCATCCGGATGGCTCGCCGGGATGTGAGTCCATTTGGTAATATTCCCCAAAGA GTAATGGGACAGATGGGGAGGTCCCTGCTGCCCAGCCGCACTTTTCTGCAGGCACTCAATCTGGGCATTGAAGTCATCAACACCACAGAC TATCTGCACTTCTCCAAAGAGTGCAGCAGAGCCCTCCTGAAGATGCAATACTGCCCGCACTGCCAAGGCCTGGCGCTCACTAAGCCTTGT ATGGGATACTGCCTCAATGTCATGCGAGGCTGCCTGGCGCACATGGCGGAGCTTAATCCACACTGGCATGCATATATCCGGTCGTTGGAA GAACTCTCGGATGCAATGCATGGAACATACGACATTGGACACGTGCTGCTGAACTTTCACTTGCTTGTTAATGATGCTGTGTTACAGGCT CACCTCAATGGACAAAAATTATTGGAACAGGTAAATAGGATTTGTGGCCGCCCTGTAAGAACACCCACACAAAGCCCCCGTTGTTCTTTT GATCAGAGCAAAGAGAAGCATGGAATGAAGACCACCACAAGGAACAGTGAAGAGACGCTTGCCAACAGAAGAAAAGAATTTATCAACAGC CTTCGACTGTACAGGTCATTCTATGGAGGTCTAGCTGATCAGCTTTGTGCTAATGAATTAGCTGCTGCAGATGGACTTCCCTGCTGGAAT GGAGAAGATATAGTAAAAAGTTATACTCAGCGTGTGGTTGGAAATGGAATCAAAGCCCAGTCTGGAAATCCTGAAGTCAAAGTCAAAGGA ATTGATCCTGTGATAAATCAGATTATTGATAAACTGAAGCATGTTGTTCAGTTGTTACAGGGTAGATCACCCAAACCTGACAAGTGGGAA CTTCTTCAGCTGGGCAGTGGTGGAGGCATGGTTGAACAAGTCAGTGGGGACTGTGATGATGAAGATGGTTGCGGGGGATCAGGAAGTGGA GAAGTCAAGAGGACACTGAAGATCACAGACTGCATTGTCAAGGATTCTGAAGACATTTACAATTTAAAGAACCCCACTTTGTTCATTTTT GCTGAAAATGATGTTGTGATTCCACTCAAGGACGTATCTTTGCTGACTCAGAAGTTGAAAGAACACTGCAAAGTTGAATATCAAATTAAA ACATTTTCTGGGCAGACTCATGGGTTCGTGCATCGGAAGAGAGAAGATTGCTCACCTGCAGACAAGCCCTACATTGACGAGGCCAGAAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GPC5_ENST00000377067_chr13_92797242_+_CMBL_ENST00000296658_chr5_10282400_-_3381nt GGCAGTGGCGGCAGTGGCGGCAGTGGCGGCAGCGGCAGCAGTTGCAGCAGTGGTGGCCAGAGCGGATGCTTGCGGGCTCCCTGCGGCTCC ACTAGTTTTCTTCGCCCCGCCCAGCCGCCCACTCTTCTCGGCTAGGGAAGAAGACCAGAGGGTGCTCAGCTGGAAAACTCTGGTGTCTCA GCTTAGGGCCTCCTCCGGGAAGAGCTAACTGCTCCCAGGTGAAGCCGGTGCCCGCGGGCGGTCCGTACACCCCGCAGCCGGCTCGCACCG CTCGAGAGCCTCGGCCGCTGTGTCTTCCACGTCTGCAGCTCAGCCAGGGCGCGCAGGGCGAGTGGGGTCCACTGGCGGGTAAAGGGGACC AGGACGGCGAGGATGGACGCACAGACCTGGCCCGTGGGCTTTCGCTGCCTCCTCCTTCTGGCCCTGGTTGGGTCCGCCCGCAGCGAGGGC GTGCAGACCTGCGAAGAAGTTCGGAAACTTTTCCAGTGGCGGCTGCTGGGAGCTGTCAGGGGGCTGCCGGATTCGCCGCGGGCAGGACCT GATCTTCAGGTTTGCATATCCAAAAAGCCTACATGTTGCACCAGGAAGATGGAGGAGAGATATCAGATTGCGGCTCGCCAGGATATGCAG CAGTTTCTTCAAACGTCCAGCTCTACATTAAAGTTTCTAATATCTCGAAATGCGGCTGCTTTTCAAGAAACCCTTGAAACTCTCATCAAA CAAGCAGAAAATTACACCAGTATACTTTTTTGCAGTACCTACAGGAACATGGCCTTGGAGGCTGCTGCTTCGGTTCAGGAGTTCTTCACT GATGTGGGGCTGTATTTATTTGGTGCGGATGTTAATCCTGAAGAATTTGTAAACAGATTTTTTGACAGTCTTTTTCCTCTGGTCTACAAC CACCTCATTAACCCTGGTGTGACTGACAGTTCCCTGGAATACTCAGAATGCATCCGGATGGCTCGCCGGGATGTGAGTCCATTTGGTAAT ATTCCCCAAAGAGTAATGGGACAGATGGGGAGGTCCCTGCTGCCCAGCCGCACTTTTCTGCAGGCACTCAATCTGGGCATTGAAGTCATC AACACCACAGACTATCTGCACTTCTCCAAAGAGTGCAGCAGAGCCCTCCTGAAGATGCAATACTGCCCGCACTGCCAAGGCCTGGCGCTC ACTAAGCCTTGTATGGGATACTGCCTCAATGTCATGCGAGGCTGCCTGGCGCACATGGCGGAGCTTAATCCACACTGGCATGCATATATC CGGTCGTTGGAAGAACTCTCGGATGCAATGCATGGAACATACGACATTGGACACGTGCTGCTGAACTTTCACTTGCTTGTTAATGATGCT GTGTTACAGGCTCACCTCAATGGACAAAAATTATTGGAACAGGTAAATAGGATTTGTGGCCGCCCTGTAAGAACACCCACACAAAGCCCC CGTTGTTCTTTTGATCAGAGCAAAGAGAAGCATGGAATGAAGACCACCACAAGGAACAGTGAAGAGACGCTTGCCAACAGAAGAAAAGAA TTTATCAACAGCCTTCGACTGTACAGGTCATTCTATGGAGGTCTAGCTGATCAGCTTTGTGCTAATGAATTAGCTGCTGCAGATGGACTT CCCTGCTGGAATGGAGAAGATATAGTAAAAAGTTATACTCAGCGTGTGGTTGGAAATGGAATCAAAGCCCAGTCTGGAAATCCTGAAGTC AAAGTCAAAGGAATTGATCCTGTGATAAATCAGATTATTGATAAACTGAAGCATGTTGTTCAGTTGTTACAGGGTAGATCACCCAAACCT GACAAGTGGGAACTTCTTCAGCTGGGCAGTGGTGGAGGCATGGTTGAACAAGTCAGTGGGGACTGTGATGATGAAGATGGTTGCGGGGGA TCAGGAAGTGGAGAAGTCAAGAGGACACTGAAGATCACAGACTGCATTGTCAAGGATTCTGAAGACATTTACAATTTAAAGAACCCCACT TTGTTCATTTTTGCTGAAAATGATGTTGTGATTCCACTCAAGGACGTATCTTTGCTGACTCAGAAGTTGAAAGAACACTGCAAAGTTGAA TATCAAATTAAAACATTTTCTGGGCAGACTCATGGGTTCGTGCATCGGAAGAGAGAAGATTGCTCACCTGCAGACAAGCCCTACATTGAC GAGGCCAGAAGGAATTTAATTGAGTGGCTGAACAAGTACATGTAGCAAGAATCAAGGGCAAGCCTTCCTAGAATAGCTTTCATCCCAAAA TTTGCTTGGAAATAGTTAGATCATTTGATTTAATTTTCACTTTTATAAAATAAGTGTAGGAATCCTAAAATTGATTATTTCATTTGAAAC ACAAATTCAGTAGGACGTAATGCATGAAATAATTTAATTTTTGACATGTACATCGAATCATAATTTAAAAACAAGGTCTGACCAGGTGTA GTGCCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCAAAGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATG GTGAGACCCCATCTCTACAAAAAATACAAAAATTAGCCTGGTGTGGTGGTGCACGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCACA AGAATCAATAGAACCCAGGAGGTGGAGACTGCAGTGAGCCAAGATTGTGCCACTACTGTACTCTAGCCTGGGCAGCAGAGTGAGACCCTG TCTCAAAAATAAATAAGTAAATAAATAAATAAATAAAATAAAAACCAGGTCAGTACCTGGAGAATTTGAATGATAGAGAATGATAGAGTA ATACCCTAATTATTAGTTAAAACCTACAGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATC ACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATATAAAAATCAGCCGGGCATGGTGGCA TGTGCCTGTAATCCCAGCTACTCAGGAGTCTGAGGAGGAGAATCACTTGAACCTGGAGGCAGAGGTTGCAGTGAGTCGAGGTTGCGCTAC TGCACTCCAGCCTGGACAACAGAGGGAGACTCTGTCTCAAAAAAAAAAAAAAACCTACAGCTGTTCAAGGACCAGCTGACAGGTCAAGTG TGGCCTTTTCTGGTCTTTGAACACATCATAGAAAGTGACAAATGCTGCAAAGCCATGAAGAACATGAACTATAAACGGGTAGACTAACTG CCCAGCTTAGACACTTATCTATGCCACAAAACAGCTGAATTTGTCACATTTATATATTGCAATATGGGAAGTATTGAGATCAAAACAGGA |
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FusionGenePPI for GPC5_CMBL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPC5 | DCPS | CMBL | ARRB1, ATIC, CD2BP2, CUL2, EIF4A2, H2AFX, SMURF1, PAN2, BAG3, SMS, SNCA, SAP30, KIF20B, CRBN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPC5_CMBL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPC5_CMBL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPC5 | C0001925 | Albuminuria | 1 | CTD_human |
| Hgene | GPC5 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
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