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Fusion gene ID: 15178 |
FusionGeneSummary for GPC4_GPC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPC4_GPC3 | Fusion gene ID: 15178 | Hgene | Tgene | Gene symbol | GPC4 | GPC3 | Gene ID | 2239 | 2719 |
| Gene name | glypican 4 | glypican 3 | |
| Synonyms | K-glypican | DGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1 | |
| Cytomap | Xq26.2 | Xq26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glypican-4dJ900E8.1 (glypican 4)glypican proteoglycan 4 | glypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | O75487 | P51654 | |
| Ensembl transtripts involved in fusion gene | ENST00000370828, ENST00000535467, | ENST00000370818, ENST00000394299, ENST00000543339, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 7 X 6 X 4=168 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPC4 [Title/Abstract] AND GPC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | TGCT | TCGA-2G-AAKD-01A | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000370828 | ENST00000370818 | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
| Frame-shift | ENST00000370828 | ENST00000394299 | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
| In-frame | ENST00000370828 | ENST00000543339 | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
| intron-3CDS | ENST00000535467 | ENST00000370818 | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
| intron-3CDS | ENST00000535467 | ENST00000394299 | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
| intron-3CDS | ENST00000535467 | ENST00000543339 | GPC4 | chrX | 132548834 | - | GPC3 | chrX | 132670321 | - |
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FusionProtFeatures for GPC4_GPC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPC4 | GPC3 |
| Cell surface proteoglycan that bears heparan sulfate.May be involved in the development of kidney tubules and of thecentral nervous system (By similarity). {ECO:0000250}. | Cell surface proteoglycan that bears heparan sulfate.Inhibits the dipeptidyl peptidase activity of DPP4. May beinvolved in the suppression/modulation of growth in thepredominantly mesodermal tissues and organs. May play a role inthe modulation of IGF2 interactions with its receptor and therebymodulate its function. May regulate growth and tumorpredisposition. {ECO:0000269|PubMed:17549790}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPC4_GPC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GPC4_ENST00000370828_chrX_132548834_-_GPC3_ENST00000543339_chrX_132670321_-_110aa MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GPC4_ENST00000370828_chrX_132548834_-_GPC3_ENST00000543339_chrX_132670321_-_330nt ATGGCACGGTTCGGCTTGCCCGCGCTTCTCTGCACCCTGGCAGTGCTCAGCGCCGCGCTGCTGGCTGCCGAGCTCAAGTCGAAAAGTTGC TCGGAAGTGCGACGTCTTTACGTGTCCAAAGGCTTCAACAAGAACGATGCCCCCCTCCACGAGATCAACGAACTGGCCTATGATCTGGAT GTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GPC4_ENST00000370828_chrX_132548834_-_GPC3_ENST00000543339_chrX_132670321_-_855nt CAGTCAATCAGCGGCAGAGCTGAGAAGGGCACAGCCGCGCGGCGGAGGGCAGAGTCAGCCGAGCCGAGTCCAGCCGGACGAGCGGACCAG CGCAGGGCAGCCCAAGCAGCGCGCAGCGAACGCCCGCCGCCGCCCACACCCTCTGCGGTCCCCGCGGCGCCTGCCACCCTTCCCTCCTTC CCCGCGTCCCCGCCTCGCCGGCCAGTCAGCTTGCCGGGTTCGCTGCCCCGCGAAACCCCGAGGTCACCAGCCCGCGCCTCTGCTTCCCTG GGCCGCGCGCCGCCTCCACGCCCTCCTTCTCCCCTGGCCCGGCGCCTGGCACCGGGGACCGTTGCCTGACGCGAGGCCCAGCTCTACTTT TCGCCCCGCGTCTCCTCCGCCTGCTCGCCTCTTCCACCAACTCCAACTCCTTCTCCCTCCAGCTCCACTCGCTAGTCCCCGACTCCGCCA GCCCTCGGCCCGCTGCCGTAGCGCCGCTTCCCGTCCGGTCCCAAAGGTGGGAACGCGTCCGCCCCGGCCCGCACCATGGCACGGTTCGGC TTGCCCGCGCTTCTCTGCACCCTGGCAGTGCTCAGCGCCGCGCTGCTGGCTGCCGAGCTCAAGTCGAAAAGTTGCTCGGAAGTGCGACGT CTTTACGTGTCCAAAGGCTTCAACAAGAACGATGCCCCCCTCCACGAGATCAACGAACTGGCCTATGATCTGGATGTGGATGATGCGCCT GGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCGCTGAAGCTTCTCACC |
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FusionGenePPI for GPC4_GPC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPC4 | FGF2, SQSTM1, IQCB1, SOX2, BAG3, CSNK2A2, GPR183, ASCC2, PTEN, SPICE1, AKAP9, ABHD17A, CCNC, GPC6, CAMKV, SPCS2, SCGB2A2, MPPE1, ADAM21 | GPC3 | FGF2, TAZ, GPR183, LMAN2, LRRTM2, PIP5K1A, CAMKV, ULBP1, C4orf26, SIGLECL1, SCGB2A2, FGF1, TSPYL1, NRN1, MOXD1, ISLR, LIPG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPC4_GPC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPC4_GPC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPC4 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | GPC3 | C0025500 | Mesothelioma | 1 | CTD_human |
| Tgene | GPC3 | C0796154 | SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | GPC3 | C2239176 | Liver carcinoma | 1 | CTD_human |
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