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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15176

FusionGeneSummary for GPC3_PPARG

check button Fusion gene summary
Fusion gene informationFusion gene name: GPC3_PPARG
Fusion gene ID: 15176
HgeneTgene
Gene symbol

GPC3

PPARG

Gene ID

2719

5468

Gene nameglypican 3peroxisome proliferator activated receptor gamma
SynonymsDGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma
Cytomap

Xq26.2

3p25.2

Type of geneprotein-codingprotein-coding
Descriptionglypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1
Modification date2018052720180523
UniProtAcc

P51654

P37231

Ensembl transtripts involved in fusion geneENST00000370818, ENST00000394299, 
ENST00000543339, 		ENST00000397010, 
ENST00000309576, ENST00000397015, 
ENST00000397012, ENST00000397026, 
ENST00000397000, ENST00000539812, 
ENST00000287820, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 5 X 4=160
# samples 313
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/160*10)=-0.299560281858908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPC3 [Title/Abstract] AND PPARG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPARG

GO:0000122

negative regulation of transcription by RNA polymerase II

12700342

TgenePPARG

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

18293083

TgenePPARG

GO:0007165

signal transduction

9568716

TgenePPARG

GO:0010742

macrophage derived foam cell differentiation

26504087

TgenePPARG

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

TgenePPARG

GO:0010871

negative regulation of receptor biosynthetic process

12700342

TgenePPARG

GO:0010887

negative regulation of cholesterol storage

19114110

TgenePPARG

GO:0010891

negative regulation of sequestering of triglyceride

12700342

TgenePPARG

GO:0016525

negative regulation of angiogenesis

28566713

TgenePPARG

GO:0030224

monocyte differentiation

9568716

TgenePPARG

GO:0032526

response to retinoic acid

16239304

TgenePPARG

GO:0042953

lipoprotein transport

9568716

TgenePPARG

GO:0043537

negative regulation of blood vessel endothelial cell migration

28566713

TgenePPARG

GO:0045713

low-density lipoprotein particle receptor biosynthetic process

9568716

TgenePPARG

GO:0045944

positive regulation of transcription by RNA polymerase II

9568715|12700342|16239304|17611579

TgenePPARG

GO:0048469

cell maturation

9568716

TgenePPARG

GO:0048662

negative regulation of smooth muscle cell proliferation

20622039

TgenePPARG

GO:0051091

positive regulation of DNA binding transcription factor activity

18293083

TgenePPARG

GO:0061614

pri-miRNA transcription by RNA polymerase II

28566713

TgenePPARG

GO:0071404

cellular response to low-density lipoprotein particle stimulus

9568716

TgenePPARG

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

28522568


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BL-A0C8-01AGPC3chrX

133087077

-PPARGchr3

12421203

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000370818ENST00000397010GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000309576GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000397015GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000397012GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000397026GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000397000GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000539812GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000370818ENST00000287820GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000397010GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000309576GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000397015GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000397012GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000397026GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000397000GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000539812GPC3chrX

133087077

-PPARGchr3

12421203

+
5CDS-5UTRENST00000394299ENST00000287820GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000397010GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000309576GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000397015GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000397012GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000397026GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000397000GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000539812GPC3chrX

133087077

-PPARGchr3

12421203

+
intron-5UTRENST00000543339ENST00000287820GPC3chrX

133087077

-PPARGchr3

12421203

+

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FusionProtFeatures for GPC3_PPARG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPC3

P51654

PPARG

P37231

Cell surface proteoglycan that bears heparan sulfate.Inhibits the dipeptidyl peptidase activity of DPP4. May beinvolved in the suppression/modulation of growth in thepredominantly mesodermal tissues and organs. May play a role inthe modulation of IGF2 interactions with its receptor and therebymodulate its function. May regulate growth and tumorpredisposition. {ECO:0000269|PubMed:17549790}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPC3_PPARG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPC3_PPARG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPC3FGF2, TAZ, GPR183, LMAN2, LRRTM2, PIP5K1A, CAMKV, ULBP1, C4orf26, SIGLECL1, SCGB2A2, FGF1, TSPYL1, NRN1, MOXD1, ISLR, LIPGPPARGNCOA4, GADD45G, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, SMAD2, ZFYVE9, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, FLYWCH2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPC3_PPARG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePPARGP37231DB00244MesalazinePeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB00573FenoprofenPeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB00795SulfasalazinePeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB01039FenofibratePeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB01050IbuprofenPeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB13873Fenofibric acidPeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB00313Valproic AcidPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00328IndomethacinPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00412RosiglitazonePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00731NateglinidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00912RepaglinidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00966TelmisartanPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01014BalsalazidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01067GlipizidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01118AmiodaronePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01132PioglitazonePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01252MitiglinidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01393BezafibratePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB08604TriclosanPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB09213DexibuprofenPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational

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RelatedDiseases for GPC3_PPARG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPC3C0025500Mesothelioma1CTD_human
HgeneGPC3C0796154SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 11CTD_human;ORPHANET;UNIPROT
HgeneGPC3C2239176Liver carcinoma1CTD_human
TgenePPARGC0011860Diabetes Mellitus, Non-Insulin-Dependent5CTD_human
TgenePPARGC0011853Diabetes Mellitus, Experimental3CTD_human
TgenePPARGC0020538Hypertensive disease3CTD_human;HPO
TgenePPARGC0021655Insulin Resistance3CTD_human;HPO
TgenePPARGC0035126Reperfusion Injury3CTD_human
TgenePPARGC2609414Acute kidney injury3CTD_human
TgenePPARGC0002395Alzheimer's Disease2CTD_human
TgenePPARGC0021368Inflammation2CTD_human
TgenePPARGC0022116Ischemia2CTD_human
TgenePPARGC0028754Obesity2CTD_human;HPO;UNIPROT
TgenePPARGC0030297Pancreatic Neoplasm2CTD_human
TgenePPARGC0038356Stomach Neoplasms2CTD_human
TgenePPARGC1720861Familial Partial Lipodystrophy, Type 32ORPHANET;UNIPROT
TgenePPARGC0001418Adenocarcinoma1CTD_human
TgenePPARGC0004153Atherosclerosis1CTD_human
TgenePPARGC0004763Barrett Esophagus1CTD_human
TgenePPARGC0009375Colonic Neoplasms1CTD_human
TgenePPARGC0009404Colorectal Neoplasms1CTD_human
TgenePPARGC0010346Crohn Disease1CTD_human
TgenePPARGC0011849Diabetes Mellitus1CTD_human;HPO
TgenePPARGC0017658Glomerulonephritis1CTD_human
TgenePPARGC0018801Heart failure1CTD_human
TgenePPARGC0023794Lipoidosis1CTD_human
TgenePPARGC0023903Liver neoplasms1CTD_human
TgenePPARGC0025202melanoma1CTD_human
TgenePPARGC0025517Metabolic Diseases1CTD_human
TgenePPARGC0027746Nerve Degeneration1CTD_human
TgenePPARGC0029408Degenerative polyarthritis1CTD_human
TgenePPARGC0033860Psoriasis1CTD_human
TgenePPARGC0036341Schizophrenia1PSYGENET
TgenePPARGC0040136Thyroid Neoplasm1CTD_human
TgenePPARGC0079772T-Cell Lymphoma1CTD_human
TgenePPARGC0085413Polycystic Kidney, Autosomal Dominant1CTD_human
TgenePPARGC0221406Pituitary-dependent Cushing's disease1CTD_human
TgenePPARGC0236811Chronobiology Disorders1CTD_human
TgenePPARGC0242339Dyslipidemias1CTD_human
TgenePPARGC0242488Acute Lung Injury1CTD_human
TgenePPARGC0271694Familial partial lipodystrophy1CTD_human
TgenePPARGC0282548Leukostasis1CTD_human
TgenePPARGC0525045Mood Disorders1PSYGENET
TgenePPARGC2239176Liver carcinoma1CTD_human
TgenePPARGC2931367Thyroid cancer, follicular1CTD_human