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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15164

FusionGeneSummary for GPBP1_DERL2

check button Fusion gene summary
Fusion gene informationFusion gene name: GPBP1_DERL2
Fusion gene ID: 15164
HgeneTgene
Gene symbol

GPBP1

DERL2

Gene ID

65056

51009

Gene nameGC-rich promoter binding protein 1derlin 2
SynonymsGPBP|SSH6|VASCULINCGI-101|DERtrin-2|F-LAN-1|F-LANa|FLANa|derlin-2
Cytomap

5q11.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionvasculinvascular wall-linked proteinderlin-2Der1-like domain family, member 2carcinoma relateddegradation in endoplasmic reticulum protein 2
Modification date2018052320180519
UniProtAcc

Q86WP2

Q9GZP9

Ensembl transtripts involved in fusion geneENST00000424459, ENST00000514387, 
ENST00000506184, ENST00000454432, 
ENST00000511209, ENST00000264779, 
ENST00000538707, 		ENST00000158771, 
ENST00000572834, ENST00000570848, 
ENST00000571968, 
Fusion gene scores* DoF score7 X 7 X 4=1961 X 1 X 1=1
# samples 71
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: GPBP1 [Title/Abstract] AND DERL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDERL2

GO:0008284

positive regulation of cell proliferation

11500051

TgeneDERL2

GO:0030307

positive regulation of cell growth

11500051

TgeneDERL2

GO:0030968

endoplasmic reticulum unfolded protein response

16449189


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-K1-A6RU-01AGPBP1chr5

56557109

+DERL2chr17

5381319

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000424459ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000424459ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000424459ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000424459ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000514387ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000514387ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000514387ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000514387ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000506184ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000506184ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000506184ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000506184ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000454432ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000454432ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000454432ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000454432ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000511209ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000511209ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000511209ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000511209ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000264779ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000264779ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000264779ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000264779ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000538707ENST00000158771GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000538707ENST00000572834GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000538707ENST00000570848GPBP1chr5

56557109

+DERL2chr17

5381319

-
5CDS-intronENST00000538707ENST00000571968GPBP1chr5

56557109

+DERL2chr17

5381319

-

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FusionProtFeatures for GPBP1_DERL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPBP1

Q86WP2

DERL2

Q9GZP9

Functions as a GC-rich promoter-specific transactivatingtranscription factor. {ECO:0000250|UniProtKB:Q6NXH3}. Functional component of endoplasmic reticulum-associateddegradation (ERAD) for misfolded lumenal glycoproteins, but notthat of misfolded nonglycoproteins. May act by forming a channelthat allows the retrotranslocation of misfolded glycoproteins intothe cytosol where they are ubiquitinated and degraded by theproteasome. May mediate the interaction between VCP and misfoldedglycoproteins (PubMed:16186509, PubMed:16449189). May also beinvolved in endoplasmic reticulum stress-induced pre-emptivequality control, a mechanism that selectively attenuates thetranslocation of newly synthesized proteins into the endoplasmicreticulum and reroutes them to the cytosol for proteasomaldegradation (PubMed:26565908). {ECO:0000269|PubMed:16186509,ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:26565908}. (Microbial infection) In contrast to DERL1, it is notinvolved in the degradation of MHC class I heavy chains followinginfection by cytomegaloviruses. {ECO:0000269|PubMed:15215855}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPBP1_DERL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPBP1_DERL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPBP1MCRS1, DNAL4, C20orf195, PLEKHF2, HNRNPD, SORT1, TSC22D2, SLX1A, PKP3, PLCD1, OTUB2, DUSP14, SELENBP1, EPB41L5, SERPINB5, HEPHL1, HIST1H1B, LRRC15, EIF3A, EIF3C, CRYABDERL2AMFR, VIMP, VCP, DERL1, SYVN1, SEL1L, UBE2J1, FAF2, SERPINA1, BAG6, CUL2, EDEM1, OS9, SHH, HERPUD1, SARAF, HEY2, HEY1, KRTAP10-7, KRTAP10-8, KRTAP10-3, ERLEC1, STT3A, POR, UBXN4, EMC2, ARL6IP5, EMC3, ESYT1, EMC1, RPN2, RTN4, TMEM129, TCTN3, REEP5, FZD1, TMEM63B, MASTL, RTN1, PDHA1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPBP1_DERL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPBP1_DERL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource