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Fusion gene ID: 15159 |
FusionGeneSummary for GPBP1L1_PVR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPBP1L1_PVR | Fusion gene ID: 15159 | Hgene | Tgene | Gene symbol | GPBP1L1 | PVR | Gene ID | 60313 | 5817 |
| Gene name | GC-rich promoter binding protein 1 like 1 | poliovirus receptor | |
| Synonyms | SP192 | CD155|HVED|NECL5|Necl-5|PVS|TAGE4 | |
| Cytomap | 1p34.1 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vasculin-like protein 1 | poliovirus receptornectin-like protein 5 | |
| Modification date | 20180524 | 20180523 | |
| UniProtAcc | Q9HC44 | P15151 | |
| Ensembl transtripts involved in fusion gene | ENST00000290795, ENST00000355105, ENST00000479235, | ENST00000425690, ENST00000344956, ENST00000403059, ENST00000406449, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 4=64 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPBP1L1 [Title/Abstract] AND PVR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PVR | GO:0060370 | susceptibility to T cell mediated cytotoxicity | 15039383 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TM-A7C3-01A | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000290795 | ENST00000425690 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000290795 | ENST00000344956 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000290795 | ENST00000403059 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000290795 | ENST00000406449 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000355105 | ENST00000425690 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000355105 | ENST00000344956 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000355105 | ENST00000403059 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| Frame-shift | ENST00000355105 | ENST00000406449 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| intron-3CDS | ENST00000479235 | ENST00000425690 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| intron-3CDS | ENST00000479235 | ENST00000344956 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| intron-3CDS | ENST00000479235 | ENST00000403059 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
| intron-3CDS | ENST00000479235 | ENST00000406449 | GPBP1L1 | chr1 | 46124700 | - | PVR | chr19 | 45153081 | + |
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FusionProtFeatures for GPBP1L1_PVR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPBP1L1 | PVR |
| Possible transcription factor. {ECO:0000305}. | Mediates NK cell adhesion and triggers NK cell effectorfunctions. Binds two different NK cell receptors: CD96 and CD226.These interactions accumulates at the cell-cell contact site,leading to the formation of a mature immunological synapse betweenNK cell and target cell. This may trigger adhesion and secretionof lytic granules and IFN-gamma and activate cytoxicity ofactivated NK cells. May also promote NK cell-target cell modularexchange, and PVR transfer to the NK cell. This transfer is moreimportant in some tumor cells expressing a lot of PVR, and maytrigger fratricide NK cell activation, providing tumors with amechanism of immunoevasion. Plays a role in mediating tumor cellinvasion and migration. {ECO:0000269|PubMed:15471548,ECO:0000269|PubMed:15607800}. (Microbial infection) Acts as a receptor for poliovirus.May play a role in axonal transport of poliovirus, by targetingvirion-PVR-containing endocytic vesicles to the microtubularnetwork through interaction with DYNLT1. This interaction woulddrive the virus-containing vesicle to the axonal retrogradetransport. {ECO:0000269|PubMed:2538245}. (Microbial infection) Acts as a receptor forPseudorabies virus. {ECO:0000269|PubMed:9616127}. (Microbial infection) Is prevented to reach cell surfaceupon infection by Human cytomegalovirus /HHV-5, presumably toescape immune recognition of infected cell by NK cells.{ECO:0000269|PubMed:15640804}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPBP1L1_PVR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPBP1L1_PVR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPBP1L1 | EIF3E, PLEKHF2, EWSR1, ELAVL1, NXF1, XPO1, CNOT1, QRSL1, TC2N, PLCD3, KANSL2, NANOS2, PIP4K2A, SNRPF, CNOT11, AMPD2, ZBTB1, MCRS1, METAP2, PIP4K2C, UTP6, CNOT10, CNOT2, PIP4K2B, AP2A1, AP2A2, ECD, ACAD11, EIF3A, TSSC4, AP1B1, CNOT8, EPB41L5, DCAF5, EIF3C, EIF3H, AP2S1, CNOT6L, PDCD2L, SNRNP200, AP2M1, EIF3M, RQCD1, DCAF7, TRIM25 | PVR | CD226, PVRL3, DYNLT1, AP1M2, VTN, ELAVL1, ZC3HAV1, TIGIT, PLA2G3, WNK1, SLC30A2, KRTAP10-7, KRTAP10-9, KRTAP10-8, KRTAP10-3, NOTCH2NL, CD96, NLRX1, C4A, UBE2C, RYK, CDON, PI4K2A, RAB5B, LRBA, FBXL20, GNPAT, MMS22L, MTCH2, XPO6, QSOX1, ATR, FAM20B, GPD2, PPM1B, LANCL2, ALG5, USP30, ARV1, GNA13, CISD2, METAP2, XPO5, TNFSF9, HELLS, ALG11, ULBP3, STAT3, RFC3, EFNB1, FAM134A, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPBP1L1_PVR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPBP1L1_PVR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PVR | C0032371 | Poliomyelitis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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