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Fusion gene ID: 15150 |
FusionGeneSummary for GPATCH8_METTL16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPATCH8_METTL16 | Fusion gene ID: 15150 | Hgene | Tgene | Gene symbol | GPATCH8 | METTL16 | Gene ID | 23131 | 79066 |
| Gene name | G-patch domain containing 8 | methyltransferase like 16 | |
| Synonyms | GPATC8|KIAA0553 | METT10D | |
| Cytomap | 17q21.31 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | G patch domain-containing protein 8 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferaseN6-adenosine-methyltransferase METTL16U6 snRNA methyltransferasemethyltransferase 10 domain containingmethyltransferase 10 domain-containing proteinmethyltransferase-like protein 16putative m | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UKJ3 | Q86W50 | |
| Ensembl transtripts involved in fusion gene | ENST00000434000, ENST00000591680, ENST00000586265, ENST00000592154, ENST00000588554, | ENST00000571669, ENST00000263092, ENST00000538844, | |
| Fusion gene scores | * DoF score | 15 X 9 X 8=1080 | 3 X 3 X 2=18 |
| # samples | 17 | 3 | |
| ** MAII score | log2(17/1080*10)=-2.66742466091313 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GPATCH8 [Title/Abstract] AND METTL16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | METTL16 | GO:0010608 | posttranscriptional regulation of gene expression | 28525753 |
| Tgene | METTL16 | GO:0048024 | regulation of mRNA splicing, via spliceosome | 28525753 |
| Tgene | METTL16 | GO:0120049 | snRNA (adenine-N6)-methylation | 28525753|29051200 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-N1-A6IA-01A | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000434000 | ENST00000571669 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5CDS-5UTR | ENST00000434000 | ENST00000263092 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5CDS-5UTR | ENST00000434000 | ENST00000538844 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5CDS-5UTR | ENST00000591680 | ENST00000571669 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5CDS-5UTR | ENST00000591680 | ENST00000263092 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5CDS-5UTR | ENST00000591680 | ENST00000538844 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5UTR-5UTR | ENST00000586265 | ENST00000571669 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5UTR-5UTR | ENST00000586265 | ENST00000263092 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| 5UTR-5UTR | ENST00000586265 | ENST00000538844 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| intron-5UTR | ENST00000592154 | ENST00000571669 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| intron-5UTR | ENST00000592154 | ENST00000263092 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| intron-5UTR | ENST00000592154 | ENST00000538844 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| intron-5UTR | ENST00000588554 | ENST00000571669 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| intron-5UTR | ENST00000588554 | ENST00000263092 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
| intron-5UTR | ENST00000588554 | ENST00000538844 | GPATCH8 | chr17 | 42512433 | - | METTL16 | chr17 | 2381179 | - |
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FusionProtFeatures for GPATCH8_METTL16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPATCH8 | METTL16 |
| RNA N6-methyltransferase that methylates adenosineresidues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2Atranscripts (PubMed:28525753). Able to N6-methylate a subset ofmRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). Incontrast to the METTL3-METTL14 heterodimer, only able to methylatea limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamersequence and a specific RNA structure (PubMed:28525753). Inpresence of S-adenosyl-L-methionine, binds the 3'-UTR region ofMAT2A mRNA and specifically N6-methylates the first hairpin ofMAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR regionof MAT2A mRNA but stalls due to the lack of a methyl donor,preventing N6-methylation and promoting expression of MAT2A(PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753,PubMed:29051200). Also able to bind various lncRNAs(PubMed:29051200). Specifically binds the 3'-end of the MALAT1long non-coding RNA (PubMed:27872311).{ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753,ECO:0000269|PubMed:29051200}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPATCH8_METTL16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPATCH8_METTL16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPATCH8 | TERF2, ATXN1, ATXN1L, APH1A, NUMBL, CLK3, TP53, BMI1, JAK3, BTRC, HCCS, LUC7L, RBFOX2, LUC7L2, SNIP1, LACC1, EPB41L3, RNPS1, EWSR1, ABCA2, FDX1, PON2, TIMM13, TIMM8B, TMEM165, PCGF1, NANOG, PHF12, GATAD1, EGFR, PIP4K2A, EPB41L2, U2AF2, CLK2, JPH4, CAMKV, OLFM2, ESRP1, CD2BP2, TRIM25 | METTL16 | MEPCE, APP, YARS, FAM50A, HCCS, NHP2L1, TCEA1, NTRK1, METTL16, KPNA6, SLC39A9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPATCH8_METTL16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPATCH8_METTL16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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