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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15147

FusionGeneSummary for GPATCH8_IRAK4

check button Fusion gene summary
Fusion gene informationFusion gene name: GPATCH8_IRAK4
Fusion gene ID: 15147
HgeneTgene
Gene symbol

GPATCH8

IRAK4

Gene ID

23131

51135

Gene nameG-patch domain containing 8interleukin 1 receptor associated kinase 4
SynonymsGPATC8|KIAA0553IPD1|IRAK-4|NY-REN-64|REN64
Cytomap

17q21.31

12q12

Type of geneprotein-codingprotein-coding
DescriptionG patch domain-containing protein 8interleukin-1 receptor-associated kinase 4renal carcinoma antigen NY-REN-64
Modification date2018052220180523
UniProtAcc

Q9UKJ3

Q9NWZ3

Ensembl transtripts involved in fusion geneENST00000434000, ENST00000591680, 
ENST00000586265, ENST00000592154, 
ENST00000588554, 
ENST00000440781, 
ENST00000431837, ENST00000448290, 
ENST00000551736, 
Fusion gene scores* DoF score15 X 9 X 8=10804 X 3 X 4=48
# samples 174
** MAII scorelog2(17/1080*10)=-2.66742466091313
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPATCH8 [Title/Abstract] AND IRAK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA432346GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000434000ENST00000440781GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000434000ENST00000431837GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000434000ENST00000448290GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000434000ENST00000551736GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000591680ENST00000440781GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000591680ENST00000431837GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000591680ENST00000448290GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000591680ENST00000551736GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000586265ENST00000440781GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000586265ENST00000431837GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000586265ENST00000448290GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000586265ENST00000551736GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000592154ENST00000440781GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000592154ENST00000431837GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000592154ENST00000448290GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000592154ENST00000551736GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000588554ENST00000440781GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000588554ENST00000431837GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-3UTRENST00000588554ENST00000448290GPATCH8chr17

42540551

-IRAK4chr12

44181548

-
intron-intronENST00000588554ENST00000551736GPATCH8chr17

42540551

-IRAK4chr12

44181548

-

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FusionProtFeatures for GPATCH8_IRAK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPATCH8

Q9UKJ3

IRAK4

Q9NWZ3

Serine/threonine-protein kinase that plays a criticalrole in initiating innate immune response against foreignpathogens. Involved in Toll-like receptor (TLR) and IL-1Rsignaling pathways (PubMed:17878374). Is rapidly recruited byMYD88 to the receptor-signaling complex upon TLR activation toform the Myddosome together with IRAK2. Phosphorylates initiallyIRAK1, thus stimulating the kinase activity and intensiveautophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligasesPellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-bindingdomain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringingtogether the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA andIKBKB/IKKB) leading to NF-kappa-B nuclear translocation andactivation. Alternatively, phosphorylates TIRAP to promote itsubiquitination and subsequent degradation. Phosphorylates NCF1 andregulates NADPH oxidase activation after LPS stimulationsuggesting a similar mechanism during microbial infections.{ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665,ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339,ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374,ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509,ECO:0000269|PubMed:24316379}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPATCH8_IRAK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPATCH8_IRAK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPATCH8_IRAK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPATCH8_IRAK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIRAK4C0033578Prostatic Neoplasms1CTD_human
TgeneIRAK4C0752308Hypoxia-Ischemia, Brain1CTD_human
TgeneIRAK4C1843256IRAK4 Deficiency1CTD_human;ORPHANET;UNIPROT