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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15144

FusionGeneSummary for GPATCH8_GPATCH8

check button Fusion gene summary
Fusion gene informationFusion gene name: GPATCH8_GPATCH8
Fusion gene ID: 15144
HgeneTgene
Gene symbol

GPATCH8

GPATCH8

Gene ID

23131

23131

Gene nameG-patch domain containing 8G-patch domain containing 8
SynonymsGPATC8|KIAA0553GPATC8|KIAA0553
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionG patch domain-containing protein 8G patch domain-containing protein 8
Modification date2018052220180522
UniProtAcc

Q9UKJ3

Q9UKJ3

Ensembl transtripts involved in fusion geneENST00000434000, ENST00000591680, 
ENST00000586265, ENST00000592154, 
ENST00000588554, 		ENST00000434000, 
ENST00000591680, ENST00000586265, 
ENST00000592154, ENST00000588554, 
Fusion gene scores* DoF score15 X 9 X 8=10808 X 6 X 7=336
# samples 179
** MAII scorelog2(17/1080*10)=-2.66742466091313
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPATCH8 [Title/Abstract] AND GPATCH8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU852841GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
ChiTaRS3.1AA505021GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000434000ENST00000434000GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000434000ENST00000591680GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000434000ENST00000586265GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000434000ENST00000592154GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000434000ENST00000588554GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000591680ENST00000434000GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000591680ENST00000591680GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000591680ENST00000586265GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000591680ENST00000592154GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000591680ENST00000588554GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000586265ENST00000434000GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000586265ENST00000591680GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000586265ENST00000586265GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000586265ENST00000592154GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000586265ENST00000588554GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000592154ENST00000434000GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000592154ENST00000591680GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000592154ENST00000586265GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000592154ENST00000592154GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000592154ENST00000588554GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000588554ENST00000434000GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000588554ENST00000591680GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000588554ENST00000586265GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000588554ENST00000592154GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000588554ENST00000588554GPATCH8chr17

42567110

-GPATCH8chr17

42567878

-
intron-intronENST00000434000ENST00000434000GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000434000ENST00000591680GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000434000ENST00000586265GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000434000ENST00000592154GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000434000ENST00000588554GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000591680ENST00000434000GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000591680ENST00000591680GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000591680ENST00000586265GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000591680ENST00000592154GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000591680ENST00000588554GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000586265ENST00000434000GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000586265ENST00000591680GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000586265ENST00000586265GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000586265ENST00000592154GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000586265ENST00000588554GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000592154ENST00000434000GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000592154ENST00000591680GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000592154ENST00000586265GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000592154ENST00000592154GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000592154ENST00000588554GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000588554ENST00000434000GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000588554ENST00000591680GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000588554ENST00000586265GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000588554ENST00000592154GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-
intron-intronENST00000588554ENST00000588554GPATCH8chr17

42473477

+GPATCH8chr17

42473017

-

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FusionProtFeatures for GPATCH8_GPATCH8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPATCH8

Q9UKJ3

GPATCH8

Q9UKJ3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPATCH8_GPATCH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPATCH8_GPATCH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPATCH8_GPATCH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPATCH8_GPATCH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource