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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15131

FusionGeneSummary for GPALPP1_VWA8

check button Fusion gene summary
Fusion gene informationFusion gene name: GPALPP1_VWA8
Fusion gene ID: 15131
HgeneTgene
Gene symbol

GPALPP1

VWA8

Gene ID

55425

23078

Gene nameGPALPP motifs containing 1von Willebrand factor A domain containing 8
SynonymsAD029|KIAA1704|LSR7|bA245H20.2KIAA0564
Cytomap

13q14.12

13q14.11

Type of geneprotein-codingprotein-coding
DescriptionGPALPP motifs-containing protein 1lipopolysaccharide specific response-7 proteinlipopolysaccharide-specific response protein 7von Willebrand factor A domain-containing protein 8
Modification date2018051920180519
UniProtAcc

Q8IXQ4

A3KMH1

Ensembl transtripts involved in fusion geneENST00000379151, ENST00000361121, 
ENST00000357537, ENST00000473119, 
ENST00000379310, ENST00000281496, 
ENST00000478987, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 4 X 4=64
# samples 64
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPALPP1 [Title/Abstract] AND VWA8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-CM-5862-01AGPALPP1chr13

45583014

+VWA8chr13

42142441

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000379151ENST00000379310GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5CDS-intronENST00000379151ENST00000281496GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5CDS-intronENST00000379151ENST00000478987GPALPP1chr13

45583014

+VWA8chr13

42142441

-
Frame-shiftENST00000361121ENST00000379310GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5CDS-intronENST00000361121ENST00000281496GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5CDS-intronENST00000361121ENST00000478987GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5UTR-3CDSENST00000357537ENST00000379310GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5UTR-intronENST00000357537ENST00000281496GPALPP1chr13

45583014

+VWA8chr13

42142441

-
5UTR-intronENST00000357537ENST00000478987GPALPP1chr13

45583014

+VWA8chr13

42142441

-
intron-3CDSENST00000473119ENST00000379310GPALPP1chr13

45583014

+VWA8chr13

42142441

-
intron-intronENST00000473119ENST00000281496GPALPP1chr13

45583014

+VWA8chr13

42142441

-
intron-intronENST00000473119ENST00000478987GPALPP1chr13

45583014

+VWA8chr13

42142441

-

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FusionProtFeatures for GPALPP1_VWA8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPALPP1

Q8IXQ4

VWA8

A3KMH1

Exhibits ATPase activity in vitro.{ECO:0000250|UniProtKB:Q8CC88}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPALPP1_VWA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPALPP1_VWA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPALPP1HECW2, PPID, ARL6IP4, SNIP1, CDKL5, HIST1H2BG, EWSR1, XPO1, CTBP2, THOC2, PPIL1, PIP4K2A, ZNF786, C11orf57, ZNF816, ZNF311, CLK2, FUOM, PNNVWA8KEAP1, LGR4, NUDCD1, IDI1, ENDOV, PARP16, CLEC11A, BMP7, NUDT12, NTRK1, LCA5, SCLT1, PDK1, CDC23, KERA, PROSER2, HSPB8, DKKL1, EEF1D, BMP5, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPALPP1_VWA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPALPP1_VWA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVWA8C0004352Autistic Disorder1CTD_human