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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15128

FusionGeneSummary for GPALPP1_MEF2A

check button Fusion gene summary
Fusion gene informationFusion gene name: GPALPP1_MEF2A
Fusion gene ID: 15128
HgeneTgene
Gene symbol

GPALPP1

MEF2A

Gene ID

55425

4205

Gene nameGPALPP motifs containing 1myocyte enhancer factor 2A
SynonymsAD029|KIAA1704|LSR7|bA245H20.2ADCAD1|RSRFC4|RSRFC9|mef2
Cytomap

13q14.12

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionGPALPP motifs-containing protein 1lipopolysaccharide specific response-7 proteinlipopolysaccharide-specific response protein 7myocyte-specific enhancer factor 2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)serum response factor-like protein 1
Modification date2018051920180523
UniProtAcc

Q8IXQ4

Q02078

Ensembl transtripts involved in fusion geneENST00000379151, ENST00000361121, 
ENST00000357537, ENST00000473119, 
ENST00000453228, ENST00000354410, 
ENST00000558856, ENST00000558812, 
ENST00000338042, ENST00000557785, 
ENST00000449277, ENST00000557942, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 4 X 4=80
# samples 65
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPALPP1 [Title/Abstract] AND MEF2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEF2A

GO:0000122

negative regulation of transcription by RNA polymerase II

16484498

TgeneMEF2A

GO:0000165

MAPK cascade

9858528

TgeneMEF2A

GO:0006351

transcription, DNA-templated

16043483

TgeneMEF2A

GO:0010613

positive regulation of cardiac muscle hypertrophy

24161931

TgeneMEF2A

GO:0045944

positive regulation of transcription by RNA polymerase II

7760790|9858528|10748098|15466416|20590529|21468593

TgeneMEF2A

GO:0071277

cellular response to calcium ion

16484498


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-G9-6361-01AGPALPP1chr13

45563877

+MEF2Achr15

100211528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000379151ENST00000453228GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000354410GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000558856GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000558812GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000338042GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000557785GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000449277GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000379151ENST00000557942GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
Frame-shiftENST00000361121ENST00000453228GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000354410GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000558856GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000558812GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000338042GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000557785GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000449277GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
5CDS-intronENST00000361121ENST00000557942GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-3CDSENST00000357537ENST00000453228GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000354410GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000558856GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000558812GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000338042GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000557785GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000449277GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000357537ENST00000557942GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-3CDSENST00000473119ENST00000453228GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000354410GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000558856GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000558812GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000338042GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000557785GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000449277GPALPP1chr13

45563877

+MEF2Achr15

100211528

+
intron-intronENST00000473119ENST00000557942GPALPP1chr13

45563877

+MEF2Achr15

100211528

+

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FusionProtFeatures for GPALPP1_MEF2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPALPP1

Q8IXQ4

MEF2A

Q02078


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPALPP1_MEF2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPALPP1_MEF2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPALPP1HECW2, PPID, ARL6IP4, SNIP1, CDKL5, HIST1H2BG, EWSR1, XPO1, CTBP2, THOC2, PPIL1, PIP4K2A, ZNF786, C11orf57, ZNF816, ZNF311, CLK2, FUOM, PNNMEF2AVGLL4, HDAC4, HDAC9, THRA, EP300, HDAC5, SMAD2, MAPK14, ASCL1, MYOG, MAPK7, MEF2D, ACTN4, HDAC7, HDAC1, HNRNPA1, UBE2I, PHB2, ERBB2IP, DDB1, NDUFB9, GNB2, GNG12, TBP, TAF8, HDAC3, HAND1, XPO1, KLC4, JUN, ATF3, ATF7, CABIN1, HIST1H2BA, MEF2C, HIRA, REV3L, SH2B1, HIST1H2BC, HIST3H3, JUND, CCDC15, MAPKAPK3, SETX, TTLL7, ZCWPW1, ITGB1, MEF2B, XYLT1, DNMT3L, TSR3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPALPP1_MEF2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPALPP1_MEF2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMEF2AC0033975Psychotic Disorders1PSYGENET
TgeneMEF2AC0349204Nonorganic psychosis1PSYGENET