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Fusion gene ID: 15122 |
FusionGeneSummary for GOT1_FABP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GOT1_FABP1 | Fusion gene ID: 15122 | Hgene | Tgene | Gene symbol | GOT1 | FABP1 | Gene ID | 127845 | 2168 |
Gene name | golgi transport 1A | fatty acid binding protein 1 | |
Synonyms | CGI-141|GOT1|HMFN1187|YMR292W|hGOT1b | FABPL|L-FABP | |
Cytomap | 1q32.1 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | vesicle transport protein GOT1A | fatty acid-binding protein, liverfatty acid binding protein 1, liverliver-type fatty acid-binding protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P17174 | P07148 | |
Ensembl transtripts involved in fusion gene | ENST00000370508, ENST00000543866, ENST00000471741, | ENST00000295834, ENST00000393750, ENST00000495375, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 1=9 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GOT1 [Title/Abstract] AND FABP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FABP1 | GO:0043066 | negative regulation of apoptotic process | 16175609 |
Tgene | FABP1 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16175609 |
Tgene | FABP1 | GO:0070301 | cellular response to hydrogen peroxide | 16175609 |
Tgene | FABP1 | GO:0071456 | cellular response to hypoxia | 16175609 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI114691 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000370508 | ENST00000295834 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-intron | ENST00000370508 | ENST00000393750 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-intron | ENST00000370508 | ENST00000495375 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-5UTR | ENST00000543866 | ENST00000295834 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-intron | ENST00000543866 | ENST00000393750 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-intron | ENST00000543866 | ENST00000495375 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-5UTR | ENST00000471741 | ENST00000295834 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-intron | ENST00000471741 | ENST00000393750 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
intron-intron | ENST00000471741 | ENST00000495375 | GOT1 | chr10 | 101190377 | + | FABP1 | chr2 | 88427579 | - |
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FusionProtFeatures for GOT1_FABP1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GOT1 | FABP1 |
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the majorexcitatory neurotransmitter of the vertebrate central nervoussystem. Acts as a scavenger of glutamate in brain neuroprotection.The aspartate aminotransferase activity is involved in hepaticglucose synthesis during development and in adipocyteglyceroneogenesis. Using L-cysteine as substrate, regulates levelsof mercaptopyruvate, an important source of hydrogen sulfide.Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is animportant synaptic modulator and neuroprotectant in the brain.{ECO:0000269|PubMed:16039064}. | Plays a role in lipoprotein-mediated cholesterol uptakein hepatocytes (PubMed:25732850). Binds cholesterol(PubMed:25732850). Binds free fatty acids and their coenzyme Aderivatives, bilirubin, and some other small molecules in thecytoplasm. May be involved in intracellular lipid transport (Bysimilarity). {ECO:0000250|UniProtKB:P82289,ECO:0000269|PubMed:25732850}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GOT1_FABP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GOT1_FABP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GOT1_FABP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GOT1 | P17174 | DB00114 | Pyridoxal Phosphate | Aspartate aminotransferase, cytoplasmic | small molecule | approved|investigational|nutraceutical |
Hgene | GOT1 | P17174 | DB00142 | Glutamic Acid | Aspartate aminotransferase, cytoplasmic | small molecule | approved|nutraceutical |
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RelatedDiseases for GOT1_FABP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GOT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | GOT1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | FABP1 | C0023794 | Lipoidosis | 2 | CTD_human |
Tgene | FABP1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Tgene | FABP1 | C0022672 | Acute Kidney Tubular Necrosis | 1 | CTD_human |