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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15119

FusionGeneSummary for GOSR2_OMG

check button Fusion gene summary
Fusion gene informationFusion gene name: GOSR2_OMG
Fusion gene ID: 15119
HgeneTgene
Gene symbol

GOSR2

OMG

Gene ID

9570

4974

Gene namegolgi SNAP receptor complex member 2oligodendrocyte myelin glycoprotein
SynonymsBos1|EPM6|GS27OMGP
Cytomap

17q21.32

17q11.2

Type of geneprotein-codingprotein-coding
DescriptionGolgi SNAP receptor complex member 227 kDa Golgi SNARE proteinmembrinoligodendrocyte-myelin glycoprotein
Modification date2018052720180519
UniProtAcc

O14653

P23515

Ensembl transtripts involved in fusion geneENST00000439730, ENST00000576910, 
ENST00000393456, ENST00000415811, 
ENST00000575949, ENST00000225567, 
ENST00000247271, ENST00000584094, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 3 X 1=9
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GOSR2 [Title/Abstract] AND OMG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOSR2

GO:0006888

ER to Golgi vesicle-mediated transport

9349823

HgeneGOSR2

GO:0006891

intra-Golgi vesicle-mediated transport

9349823


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A27T-01AGOSR2chr17

45012535

+OMGchr17

29605258

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000439730ENST00000247271GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000439730ENST00000584094GOSR2chr17

45012535

+OMGchr17

29605258

-
intron-intronENST00000576910ENST00000247271GOSR2chr17

45012535

+OMGchr17

29605258

-
intron-intronENST00000576910ENST00000584094GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000393456ENST00000247271GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000393456ENST00000584094GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000415811ENST00000247271GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000415811ENST00000584094GOSR2chr17

45012535

+OMGchr17

29605258

-
intron-intronENST00000575949ENST00000247271GOSR2chr17

45012535

+OMGchr17

29605258

-
intron-intronENST00000575949ENST00000584094GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000225567ENST00000247271GOSR2chr17

45012535

+OMGchr17

29605258

-
5CDS-intronENST00000225567ENST00000584094GOSR2chr17

45012535

+OMGchr17

29605258

-

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FusionProtFeatures for GOSR2_OMG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOSR2

O14653

OMG

P23515

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}. Cell adhesion molecule contributing to the interactiveprocess required for myelination in the central nervous system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GOSR2_OMG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GOSR2_OMG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GOSR2STX5, USO1, APP, STX4, STX6, CCDC155, GOLGA8EP, GOLGA8F, STX7, STX12, CLEC12A, PHB, TCTN2, TCTN3, TMEM17, VAPA, CSGALNACT2, DKK3, SEC22B, TRDN, VAMP4, TRIM25, LMNAOMGRTN4R


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOSR2_OMG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GOSR2_OMG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGOSR2C3279627EPILEPSY, PROGRESSIVE MYOCLONIC, 61ORPHANET;UNIPROT