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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15108

FusionGeneSummary for GORASP2_MYO3B

check button Fusion gene summary
Fusion gene informationFusion gene name: GORASP2_MYO3B
Fusion gene ID: 15108
HgeneTgene
Gene symbol

GORASP2

MYO3B

Gene ID

26003

140469

Gene namegolgi reassembly stacking protein 2myosin IIIB
SynonymsGOLPH6|GRASP55|GRS2|p59-
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
DescriptionGolgi reassembly-stacking protein 2golgi phosphoprotein 6golgi reassembly stacking protein 2, 55kDamyosin-IIIb
Modification date2018052320180519
UniProtAcc

Q9H8Y8

Q8WXR4

Ensembl transtripts involved in fusion geneENST00000234160, ENST00000493692, 
ENST00000452526, 
ENST00000408978, 
ENST00000409044, ENST00000334231, 
ENST00000602629, 
Fusion gene scores* DoF score8 X 6 X 4=1922 X 2 X 2=8
# samples 82
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: GORASP2 [Title/Abstract] AND MYO3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-2297-01AGORASP2chr2

171785913

+MYO3Bchr2

171508138

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000234160ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
Frame-shiftENST00000234160ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
Frame-shiftENST00000234160ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5CDS-3UTRENST00000234160ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3CDSENST00000493692ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3CDSENST00000493692ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3CDSENST00000493692ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3UTRENST00000493692ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3CDSENST00000452526ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3CDSENST00000452526ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3CDSENST00000452526ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3UTRENST00000452526ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508138

+

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FusionProtFeatures for GORASP2_MYO3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GORASP2

Q9H8Y8

MYO3B

Q8WXR4

Plays a role in the assembly and membrane stacking ofthe Golgi cisternae, and in the process by which Golgi stacksreform after mitotic breakdown. May regulate the intracellulartransport and presentation of a defined set of transmembraneproteins, such as transmembrane TGFA.{ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:21515684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GORASP2_MYO3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GORASP2_MYO3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GORASP2GOLGA2, TSC22D4, CBLB, MIF, TRAF2, RAD54B, NME1, PCBD1, PRPS1, NQO2, NUP62, TMED2, BLZF1, TMED3, TGFA, TMED10, RAB2A, SELENBP1, KCTD5, ATXN1L, APP, EWSR1, BAG3, NONO, LAMTOR5, EEF1A1, RMDN3, MAPK1, MAPK14, MAPK8, PRRC2A, LTBP3, ACBD3, BLMH, BOP1, CUL3, GARS, GTF2A1, ME1, RPUSD2, TBCD, UGDH, AES, CRYAA, DCTD, DPYSL2, EIF2B1, KIFC3, ODC1, PDE9A, PSMA3, RGS3, TCF4, TRAF1, TRAF5, ZBTB14, ZNF148, CDC23, TRAF4, TRIM38, PRDX3, MID2, DMC1, RPIA, ARL6IP1, JADE2, AAMDC, SCAND1, KCTD9, ENOX1, DUSP21, TEKT3, BEND5, MAP1LC3B, ZMAT1, C1orf94, LONRF1, ACY3, PNMA5, GABPB2, TXLNA, STOX1, CCDC153, MORN2, AHNAK, DDX43, FAM98B, EEF1A2, ELAC2, RHOA, SBDS, TECR, SHMT2, TMEM17, TMEM216, XPO1, CDH1, PGP, DUSP18, KIF14, ISCA1, TMED7, KIAA1279, TMED4, FLOT2, FLOT1, UBAP2, SCYL2, RAVER1, PDLIM1, SH3GLB1, CDK5, PRCC, SEPT7MYO3BMYC, ATP6V1B1, HSP90AA1, CDC73


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GORASP2_MYO3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GORASP2_MYO3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource