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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15097

FusionGeneSummary for GON4L_RIT1

check button Fusion gene summary
Fusion gene informationFusion gene name: GON4L_RIT1
Fusion gene ID: 15097
HgeneTgene
Gene symbol

GON4L

RIT1

Gene ID

54856

64919

Gene namegon-4 likeB cell CLL/lymphoma 11B
SynonymsGON-4|GON4|YARPATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alpha
Cytomap

1q22

14q32.2

Type of geneprotein-codingprotein-coding
DescriptionGON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homologB-cell lymphoma/leukemia 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B/TRDC fusionCOUP-TF-interacting protein 2hRit1radiation-
Modification date2018052320180523
UniProtAcc

Q3T8J9

Q92963

Ensembl transtripts involved in fusion geneENST00000437809, ENST00000368331, 
ENST00000271883, ENST00000361040, 
ENST00000471341, 
ENST00000368323, 
ENST00000539040, ENST00000368322, 
Fusion gene scores* DoF score11 X 12 X 10=13202 X 1 X 3=6
# samples 153
** MAII scorelog2(15/1320*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: GON4L [Title/Abstract] AND RIT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-2023-01AGON4Lchr1

155790397

-RIT1chr1

155874595

-
TCGARVUCECTCGA-PG-A5BC-01AGON4Lchr1

155829095

-RIT1chr1

155874595

-
TCGALDUCECTCGA-PG-A5BC-01AGON4Lchr1

155826938

-RIT1chr1

155874595

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000437809ENST00000368323GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000437809ENST00000539040GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000437809ENST00000368322GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000368331ENST00000368323GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000368331ENST00000539040GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000368331ENST00000368322GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000271883ENST00000368323GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000271883ENST00000539040GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000271883ENST00000368322GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000361040ENST00000368323GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000361040ENST00000539040GON4Lchr1

155790397

-RIT1chr1

155874595

-
Frame-shitENST00000361040ENST00000368322GON4Lchr1

155790397

-RIT1chr1

155874595

-
5UTR-3CDSENST00000471341ENST00000368323GON4Lchr1

155790397

-RIT1chr1

155874595

-
5UTR-3CDSENST00000471341ENST00000539040GON4Lchr1

155790397

-RIT1chr1

155874595

-
5UTR-3CDSENST00000471341ENST00000368322GON4Lchr1

155790397

-RIT1chr1

155874595

-
5UTR-3CDSENST00000437809ENST00000368323GON4Lchr1

155829095

-RIT1chr1

155874595

-
5UTR-3CDSENST00000437809ENST00000539040GON4Lchr1

155829095

-RIT1chr1

155874595

-
5UTR-3CDSENST00000437809ENST00000368322GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000368331ENST00000368323GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000368331ENST00000539040GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000368331ENST00000368322GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000271883ENST00000368323GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000271883ENST00000539040GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000271883ENST00000368322GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000361040ENST00000368323GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000361040ENST00000539040GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000361040ENST00000368322GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000471341ENST00000368323GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000471341ENST00000539040GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000471341ENST00000368322GON4Lchr1

155829095

-RIT1chr1

155874595

-
intron-3CDSENST00000437809ENST00000368323GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000437809ENST00000539040GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000437809ENST00000368322GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000368331ENST00000368323GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000368331ENST00000539040GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000368331ENST00000368322GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000271883ENST00000368323GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000271883ENST00000539040GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000271883ENST00000368322GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000361040ENST00000368323GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000361040ENST00000539040GON4Lchr1

155826938

-RIT1chr1

155874595

-
intron-3CDSENST00000361040ENST00000368322GON4Lchr1

155826938

-RIT1chr1

155874595

-
5UTR-3CDSENST00000471341ENST00000368323GON4Lchr1

155826938

-RIT1chr1

155874595

-
5UTR-3CDSENST00000471341ENST00000539040GON4Lchr1

155826938

-RIT1chr1

155874595

-
5UTR-3CDSENST00000471341ENST00000368322GON4Lchr1

155826938

-RIT1chr1

155874595

-

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FusionProtFeatures for GON4L_RIT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GON4L

Q3T8J9

RIT1

Q92963

Plays a crucial role in coupling NGF stimulation to theactivation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1transactivation through the Ras-MAPK signaling cascade thatmediates a wide variety of cellular functions, including cellproliferation, survival, and differentiation.{ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GON4L_RIT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GON4L_RIT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GON4LDHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25RIT1RALGDS, PTN, LRIF1, MLLT4, RLF, VHL, NF2, KLHL12, ASB4, SRPK2, LZTR1, CAMKV, RIT2, MAD2L1BP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GON4L_RIT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GON4L_RIT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGON4LC3714756Intellectual Disability1CTD_human
TgeneRIT1C3809233NOONAN SYNDROME 82UNIPROT
TgeneRIT1C0023893Liver Cirrhosis, Experimental1CTD_human