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Fusion gene ID: 15085 |
FusionGeneSummary for GOLPH3_SLC6A19 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GOLPH3_SLC6A19 | Fusion gene ID: 15085 | Hgene | Tgene | Gene symbol | GOLPH3 | SLC6A19 | Gene ID | 64083 | 340024 |
| Gene name | golgi phosphoprotein 3 | solute carrier family 6 member 19 | |
| Synonyms | GOPP1|GPP34|MIDAS|Vps74 | B0AT1|HND | |
| Cytomap | 5p13.3 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Golgi phosphoprotein 3coat protein GPP34coat-proteingolgi peripheral membrane protein 1, 34 kDagolgi proteingolgi-associated proteinmitochondrial DNA absence factor | sodium-dependent neutral amino acid transporter B(0)AT1sodium-dependent amino acid transporter system B0solute carrier family 6 (neurotransmitter transporter), member 19solute carrier family 6 (neutral amino acid transporter), member 19system B(0) neu | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H4A6 | Q695T7 | |
| Ensembl transtripts involved in fusion gene | ENST00000265070, ENST00000512668, | ENST00000304460, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 5 X 3 X 5=75 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GOLPH3 [Title/Abstract] AND SLC6A19 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GOLPH3 | GO:0010821 | regulation of mitochondrion organization | 16263763 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5496-01A | GOLPH3 | chr5 | 32173916 | - | SLC6A19 | chr5 | 1219018 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265070 | ENST00000304460 | GOLPH3 | chr5 | 32173916 | - | SLC6A19 | chr5 | 1219018 | + |
| 5UTR-3CDS | ENST00000512668 | ENST00000304460 | GOLPH3 | chr5 | 32173916 | - | SLC6A19 | chr5 | 1219018 | + |
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FusionProtFeatures for GOLPH3_SLC6A19 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GOLPH3 | SLC6A19 |
| Phosphatidylinositol-4-phosphate-binding protein thatlinks Golgi membranes to the cytoskeleton and may participate inthe tensile force required for vesicle budding from the Golgi.Thereby, may play a role in Golgi membrane trafficking and couldindirectly give its flattened shape to the Golgi apparatus. Mayalso bind to the coatomer to regulate Golgi membrane trafficking.May play a role in anterograde transport from the Golgi to theplasma membrane and regulate secretion. Has also been involved inthe control of the localization of Golgi enzymes throughinteraction with their cytoplasmic part. May play an indirect rolein cell migration. Has also been involved in the modulation ofmTOR signaling. May also be involved in the regulation ofmitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763,ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862,ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}. | Transporter that mediates resorption of neutral aminoacids across the apical membrane of renal and intestinalepithelial cells. This uptake is sodium-dependent and chloride-independent. {ECO:0000269|PubMed:15286788}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GOLPH3 | chr5:32173916 | chr5:1219018 | ENST00000265070 | - | 1 | 4 | 48_51 | 75 | 299 | Compositional bias | Note=Poly-Asp |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 435_456 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 478_490 | 391 | 635 | Topological domain | Extracellular |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 512_531 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 553_581 | 391 | 635 | Topological domain | Extracellular |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 603_634 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 414_434 | 391 | 635 | Transmembrane | Helical%3B Name%3D8 |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 457_477 | 391 | 635 | Transmembrane | Helical%3B Name%3D9 |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 491_511 | 391 | 635 | Transmembrane | Helical%3B Name%3D10 |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 532_552 | 391 | 635 | Transmembrane | Helical%3B Name%3D11 |
| Tgene | >SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 582_602 | 391 | 635 | Transmembrane | Helical%3B Name%3D12 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GOLPH3 | chr5:32173916 | chr5:1219018 | ENST00000265070 | - | 1 | 4 | 190_201 | 75 | 299 | Region | Beta-hairpin required for oligomerization |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 142_192 | 391 | 635 | Topological domain | Extracellular |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 1_41 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 214_221 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 243_268 | 391 | 635 | Topological domain | Extracellular |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 290_304 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 326_413 | 391 | 635 | Topological domain | Extracellular |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 63_67 | 391 | 635 | Topological domain | Extracellular |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 89_120 | 391 | 635 | Topological domain | Cytoplasmic |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 121_141 | 391 | 635 | Transmembrane | Helical%3B Name%3D3 |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 193_213 | 391 | 635 | Transmembrane | Helical%3B Name%3D4 |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 222_242 | 391 | 635 | Transmembrane | Helical%3B Name%3D5 |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 269_289 | 391 | 635 | Transmembrane | Helical%3B Name%3D6 |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 305_325 | 391 | 635 | Transmembrane | Helical%3B Name%3D7 |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 42_62 | 391 | 635 | Transmembrane | Helical%3B Name%3D1 |
| Tgene | SLC6A19 | chr5:32173916 | chr5:1219018 | ENST00000304460 | + | 7 | 12 | 68_88 | 391 | 635 | Transmembrane | Helical%3B Name%3D2 |
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FusionGeneSequence for GOLPH3_SLC6A19 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GOLPH3_ENST00000265070_chr5_32173916_-_SLC6A19_ENST00000304460_chr5_1219018_+_319aa MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREAVEGTGLAFIVFTEA ITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLI IAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GOLPH3_ENST00000265070_chr5_32173916_-_SLC6A19_ENST00000304460_chr5_1219018_+_957nt ATGACCTCGCTGACCCAGCGCAGCTCCGGCCTGGTGCAGCGGCGCACCGAGGCCTCCCGCAACGCCGCCGACAAGGAGCGGGCGGCGGGC GGCGGCGCCGGCAGCAGCGAGGACGACGCGCAGAGCCGCCGCGACGAGCAGGACGACGACGACAAGGGCGACTCCAAGGAAACGCGGCTG ACCCTGATGGAGGAAGTGCTCCTGCTGGGCCTCAAGGACCGCGAGGCCGTGGAGGGCACAGGCCTGGCCTTCATCGTCTTCACCGAGGCC ATCACCAAGATGCCGTTGTCCCCACTGTGGTCTGTGCTCTTCTTCATTATGCTCTTCTGCCTGGGGCTGTCATCTATGTTTGGGAACATG GAGGGCGTCGTTGTGCCCCTGCAGGACCTCAGAGTCATCCCCCCGAAGTGGCCCAAGGAGGTGCTCACAGGCCTCATCTGCCTGGGGACA TTCCTCATTGGCTTCATCTTCACGCTGAACTCCGGCCAGTACTGGCTCTCCCTGCTGGACAGCTATGCCGGCTCCATTCCCCTGCTCATC ATCGCCTTCTGCGAGATGTTCTCTGTGGTCTACGTGTACGGTGTGGACAGGTTCAATAAGGACATCGAGTTCATGATCGGCCACAAGCCC AACATCTTCTGGCAAGTCACGTGGCGCGTGGTCAGCCCCCTGCTCATGCTGATCATCTTCCTCTTCTTCTTCGTGGTAGAGGTCAGTCAG GAGCTGACCTACAGCATCTGGGACCCTGGCTACGAGGAATTTCCCAAATCCCAGAAGATCTCCTACCCGAACTGGGTGTATGTGGTGGTG GTGATTGTGGCTGGAGTGCCCTCCCTCACCATCCCTGGCTATGCCATCTACAAGCTCATCAGGAACCACTGCCAGAAGCCAGGGGACCAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GOLPH3_ENST00000265070_chr5_32173916_-_SLC6A19_ENST00000304460_chr5_1219018_+_4486nt ACATCCTCCGGTGACGTCAGCCGGGGCCGCCATATTGGAAAGGCGCCGCCGCCGCCTCCGCCTTGGAGCTCGGGGTGTTTCGGGGACTGC GGCCACAGGCAGGAAGGCGCTCCTCTCCTGCCCCGCCGACGCCCGGCCAGCCCGCTTCGCCCTGACCTGTTTCCTCATGACTGCCCCCGG CCCTGCTGCCGACGGACGTCGCCCCGGCGTCCGGATTTAACACGGAAACCCGGATCGGAGGCCGCGCGGGGAGGAGGAGGGCGACCCGGT CGGTCCTGCGACCCTCTCGGCCCGGCTCGGCGCCTCGGCGGGAGCCATGACCTCGCTGACCCAGCGCAGCTCCGGCCTGGTGCAGCGGCG CACCGAGGCCTCCCGCAACGCCGCCGACAAGGAGCGGGCGGCGGGCGGCGGCGCCGGCAGCAGCGAGGACGACGCGCAGAGCCGCCGCGA CGAGCAGGACGACGACGACAAGGGCGACTCCAAGGAAACGCGGCTGACCCTGATGGAGGAAGTGCTCCTGCTGGGCCTCAAGGACCGCGA GGCCGTGGAGGGCACAGGCCTGGCCTTCATCGTCTTCACCGAGGCCATCACCAAGATGCCGTTGTCCCCACTGTGGTCTGTGCTCTTCTT CATTATGCTCTTCTGCCTGGGGCTGTCATCTATGTTTGGGAACATGGAGGGCGTCGTTGTGCCCCTGCAGGACCTCAGAGTCATCCCCCC GAAGTGGCCCAAGGAGGTGCTCACAGGCCTCATCTGCCTGGGGACATTCCTCATTGGCTTCATCTTCACGCTGAACTCCGGCCAGTACTG GCTCTCCCTGCTGGACAGCTATGCCGGCTCCATTCCCCTGCTCATCATCGCCTTCTGCGAGATGTTCTCTGTGGTCTACGTGTACGGTGT GGACAGGTTCAATAAGGACATCGAGTTCATGATCGGCCACAAGCCCAACATCTTCTGGCAAGTCACGTGGCGCGTGGTCAGCCCCCTGCT CATGCTGATCATCTTCCTCTTCTTCTTCGTGGTAGAGGTCAGTCAGGAGCTGACCTACAGCATCTGGGACCCTGGCTACGAGGAATTTCC CAAATCCCAGAAGATCTCCTACCCGAACTGGGTGTATGTGGTGGTGGTGATTGTGGCTGGAGTGCCCTCCCTCACCATCCCTGGCTATGC CATCTACAAGCTCATCAGGAACCACTGCCAGAAGCCAGGGGACCATCAGGGGCTGGTGAGCACACTGTCCACAGCCTCCATGAACGGGGA CCTGAAGTACTGAGAAGGCCCATCCCACGGCGTGCCATACACTGGTGTCAGGGAAGGAGGAACCAGCAAGACCTGTGGGGTGGGGGCCGG GCTGCACCTGCATGTGTGTAAGCGTGAGTGTATGCTCGTGTGTGAGTGTGTGTATTGTACACGCATGTGCCATGTGTGCAGATATGTATC GTGTGTGCATGTACATGCATGGGCACTGTGTGAGTGTGCACGTGTATGCACACATATACATGTGTGTGGGTGTGTGTATTGTATGTGCAT GTGCCATGTGTGCAGATGTGTCATGTTGTGTGTGTGCATGTACATGTATGGACATTGTGTGAGTGTGCAAGTGTGCATGCATATACATGT GTGCGATATTTGCTGCCCGTGTGTGTGCATGTATATATAGACATACATGCCTATGTTGTGTGTGGTGTGCATATGTGTGAACACACACGT GTATACATGCATGCACATGTGCTCGTACAATGGGTGTCCACATGCACGTGTATATGTATATCTGTGAGTGTATATACATGCATGCAATTG TGTGTATGTGTGTTCTGTGTGTGCGTTTGCAAGTATATATGCACATGTGTATATGTACATGTATGCCTGTGTGACGTGTGTATATGTGAG CATGTGTACGTGTGTGTATACGTGTGTTGTGTATATGTGTGTGTCTGTACCTGTTTGTGTATATGTGTGTGATGTGTGCTCGTGTGTGTG CATATTCAGGCAGGTGTGCATTTGTGCATGCCAGTGTGTATGTATGTGCGCATATGGACACGCATGGACACGCATATGGACACATATGGA CACACATATGGACACGTGTGGATATGTGTGCGTACACGTCGCTGGGACACATGCCTGCCACTCGGGGCCCAGCTGCCCTCTGTGTTTGTC CTTGCCACAGTCACGGGGTGCATGTGCAGAGGGGAGCAGACCACTGGGGACGTGCTGTGCCCTGCACGTGCCCGGGGGAAGCGGAAGCTG CAGCTGGGGTGGGGGCAGCACCTCTATGCTTCATCTCTGTGGGTGGCAGGAGACAAAAGCACAGGGTACTATCTTGGCTCCTGGGAGCGA CTCTTGCTACCCACCCCCACCCATCCCCTTCCCCTTGGTGTTGACCTTTGACCTGGGGGTTCCCAGAGCCCTGTAGCCCTCGACCCGGAG CAGCCTCTCGGAAGCCGGAGTGGGCAGTTGCTGGCGATTCTGAGAAAACTTGGCCGCATCCACCGGGGCCCTGCCTCCAGTCGGCCGCTG CCGAGTCTCTGCGTTCTGGCCGCTTCCCGGCTTAATGAATGCCAGCCATTTAATCATTGCTCCTGCCACCACAAATAGATGAGCAGTTAA ATAAAACTCAACTTGGCATAATTCAAGGCAAATACCACTCTGTGCATTTTCTTAAGAGGACATGAGCTGTGTGAATTTTTAGCCAGCCTT TGGAAAAGATGGGTTACAGGGTAACTCAACCCTGGCTGCCATCCTTGGGCACTGTGTGTGTCCAGGGCACCTTGGAGGACCGTGCAGCCC CCAGAAGCTTCCAGCTCCCGCACCACTCAGTGAAGCCCAGCCTGGCGCCTGCCCTGCCCCCGTCACGGGATGGGCCCCCATTGGGGTTCA ACATTCCATCGCAGCCAAAGGCAGTCGGCACTTGGGACATCTGCTTCCACGGACAGGTCACCTCCGCTTTGCACGGAAGAATCTGGATGC TTACATTAAACTGGTGTTCTGAGAGTTCCTACGGACAGGTCACCTCCGCTTTGCATGGAAGAATCTGGATGCTTACATTAAACTGGTGTT CTGAGAGTTCCTACGGACAGGTCACCTCTGCTTTCCATAGAAGAATCTGGACGCTTACATTAAACTGATGTTCTGAGAATTCCTACAGGC AGGACTGAAAGCCTGGTGTGTGCCAGTATGATGTTCCACCCACAGAAACCTGGTCACAATCGTCCCTTCCAGCACCCCATCCAGCAGTGA CTGCACACACTGAGTCCCCTACCAGCCCCTTTCACCCTGCTGACTGTCACTGGGCCCTGGGATGCGCAAGACTCCACAGCAGCAGAGGTG GGGGGACATATCACAGCCTCTGCCCCCGGCTGTGATGCCACCGAGGGGCTCGCCTGCTGATGGCTTCAACAGGGTCTCACCTCATCTTTT CCTGCTCTTTGGCCCTGGATCGAGAAAATTTCCATCAGTGCCCCATTAATATGCTGCCCTGTGGCATCTGCCCAGGAGGCCCTGCCAGGC GTGCACAGGTGTGCATTGGTGTACCCTGGCATGCACAGGTGTGCACTGATGTGCCCTGGCATCCATTGGTGTACCCTGGTGTGCCTGCCA TAGGACCCTGGGCGGGAGCTCCCATCTCATCTACATCTCCTGATTCATGCGTTGTTTCATAGGTTTCAATGTCTCTGTAAATGTGGTAGA AATGCAGGCTTTATGGGCATAAAGTGTACATTTCTAAATAAATCCCTTCTATTGAGTATGCTCACCCTAGAAGTTACTGTTGTCCAGACG TAGAGGGATGAGTGAGCCAGTGACCTCAGACGGGATGGTGGGGACGGCAGGTCCAGCTCCTGCCTCCTCCTGGGGGGTCTGGCTTTGGGG GCTTGCTCCGAAGAGGCCATGGCCCAGGCCTGTGGCCTCACAATGGGGACCAACCAGCTCTTCTCATCTTCTTCCCTCACACTTCCTCTC ACTCAAATAAGAACCTTCCAAAAATGTGTCCACCTGGGCCCCTGCCCTGGGACTCATGGATTTGGAGTTGTGGCCACACGGTTGAGGGGT GCAGTGTCCAGTGGAATGGGGCAATTGCGGGCCTGGGGGCCCTTGGCCTGTCCGTGGCGGGAGCATCTGCAAGGAGGAGCCCCAGAGTCC AGGGAGCACTGTGGGGAGCTCCTTAGAGCTGAACTCACCCGGCGTCAACTCATCAACCCTCCACCCATGGACAGGGGTGCCCCCAGCACA GGAGAGGACTCAGCCCTCTGCCCCCACGCACGGTGGGTGCCTGTCACCCTGTCCTGCCCAGCGGCCCGAGGGCAGCAGTGGGTGTGAGGG CAGCCCCCGGCCTCCCAAGAGCAGCTGAGAGGATCCCTGCGGGAATCCGGGCTTCGGGTGCATGCGATCTGATCTGAGTTGTTTCTGACA |
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FusionGenePPI for GOLPH3_SLC6A19 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GOLPH3 | ELAVL1, ARL6IP1, PNKD, P2RY12, RASSF8, GMPPB, GMPPA, WBSCR16, FAM20B, TSR3, C3orf58, AIMP1, DCUN1D1, RANBP1, PFDN4, PFDN5, RUVBL2, SRM, TIPRL, VBP1, NDUFA4, COQ9, NME4, ADCK3, C15orf48, ACN9, ADCK4, DUSP9, ST3GAL1, AMIGO3, GPRC5C, C5AR2, CHST6, CHSY3, SLC39A5, P2RX1, ENTPD7, P2RY8, TNFRSF8, STEAP1, TRIM25 | SLC6A19 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GOLPH3_SLC6A19 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GOLPH3_SLC6A19 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC6A19 | C0018609 | Hartnup Disease | 2 | CTD_human;ORPHANET;UNIPROT |
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