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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15040

FusionGeneSummary for GOLGA4_GRHL1

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLGA4_GRHL1
Fusion gene ID: 15040
HgeneTgene
Gene symbol

GOLGA4

GRHL1

Gene ID

2803

29841

Gene namegolgin A4grainyhead like transcription factor 1
SynonymsCRPF46|GCP2|GOLG|MU-RMS-40.18|p230LBP32|MGR|NH32|TFCP2L2
Cytomap

3p22.2

2p25.1

Type of geneprotein-codingprotein-coding
Descriptiongolgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230grainyhead-like protein 1 homologLBP protein 32grainyhead-like 1mammalian grainyheadtranscription factor CP2-like 2transcription factor LBP-32
Modification date2018051920180523
UniProtAcc

Q13439

Q9NZI5

Ensembl transtripts involved in fusion geneENST00000361924, ENST00000435830, 
ENST00000444882, ENST00000356847, 
ENST00000405379, ENST00000324883, 
ENST00000324907, ENST00000480736, 
Fusion gene scores* DoF score12 X 10 X 6=7203 X 3 X 1=9
# samples 133
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GOLGA4 [Title/Abstract] AND GRHL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOLGA4

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneGOLGA4

GO:0045773

positive regulation of axon extension

22705394

TgeneGRHL1

GO:0045944

positive regulation of transcription by RNA polymerase II

12175488


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE693592GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361924ENST00000405379GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000361924ENST00000324883GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000361924ENST00000324907GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000361924ENST00000480736GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000435830ENST00000405379GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000435830ENST00000324883GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000435830ENST00000324907GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000435830ENST00000480736GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000444882ENST00000405379GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000444882ENST00000324883GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000444882ENST00000324907GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
intron-intronENST00000444882ENST00000480736GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000356847ENST00000405379GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000356847ENST00000324883GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000356847ENST00000324907GOLGA4chr3

37368943

-GRHL1chr2

10136337

+
5CDS-intronENST00000356847ENST00000480736GOLGA4chr3

37368943

-GRHL1chr2

10136337

+

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FusionProtFeatures for GOLGA4_GRHL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLGA4

Q13439

GRHL1

Q9NZI5

Involved in vesicular trafficking at the Golgi apparatuslevel. May play a role in delivery of transport vesiclescontaining GPI-linked proteins from the trans-Golgi networkthrough its interaction with MACF1. Involved in endosome-to-Golgitrafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687,ECO:0000269|PubMed:29084197}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GOLGA4_GRHL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GOLGA4_GRHL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOLGA4_GRHL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GOLGA4_GRHL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGOLGA4C0033578Prostatic Neoplasms1CTD_human
HgeneGOLGA4C0037274Dermatologic disorders1CTD_human
HgeneGOLGA4C0311375Arsenic Poisoning1CTD_human