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Fusion gene ID: 15018 |
FusionGeneSummary for GOLGA2_ABCA8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GOLGA2_ABCA8 | Fusion gene ID: 15018 | Hgene | Tgene | Gene symbol | GOLGA2 | ABCA8 | Gene ID | 2801 | 10351 |
| Gene name | golgin A2 | ATP binding cassette subfamily A member 8 | |
| Synonyms | GM130 | - | |
| Cytomap | 9q34.11 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | golgin subfamily A member 2130 kDa cis-Golgi matrix proteinGM130 autoantigenGolgi matrix protein GM130SY11 proteingolgi autoantigen, golgin subfamily a, 2golgin-95 | ATP-binding cassette sub-family A member 8ATP-binding cassette, sub-family A (ABC1), member 8 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q08379 | O94911 | |
| Ensembl transtripts involved in fusion gene | ENST00000421699, ENST00000609374, ENST00000490628, | ENST00000269080, ENST00000430352, ENST00000586539, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 4 X 3 X 2=24 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GOLGA2 [Title/Abstract] AND ABCA8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GOLGA2 | GO:0007020 | microtubule nucleation | 26165940 |
| Hgene | GOLGA2 | GO:0007098 | centrosome cycle | 19109421 |
| Hgene | GOLGA2 | GO:0032091 | negative regulation of protein binding | 18167358 |
| Hgene | GOLGA2 | GO:0090307 | mitotic spindle assembly | 26165940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI049704 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000421699 | ENST00000269080 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000421699 | ENST00000430352 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000421699 | ENST00000586539 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000609374 | ENST00000269080 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000609374 | ENST00000430352 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000609374 | ENST00000586539 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000490628 | ENST00000269080 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000490628 | ENST00000430352 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
| intron-intron | ENST00000490628 | ENST00000586539 | GOLGA2 | chr9 | 131018459 | - | ABCA8 | chr17 | 66913172 | - |
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FusionProtFeatures for GOLGA2_ABCA8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GOLGA2 | ABCA8 |
| Peripheral membrane component of the cis-Golgi stackthat acts as a membrane skeleton that maintains the structure ofthe Golgi apparatus, and as a vesicle thether that facilitatesvesicle fusion to the Golgi membrane. Together with p115/USO1 andSTX5, involved in vesicle tethering and fusion at the cis-Golgimembrane to maintain the stacked and inter-connected structure ofthe Golgi apparatus. Plays a central role in mitotic Golgidisassembly: phosphorylation at Ser-37 by CDK1 at the onset ofmitosis inhibits the interaction with p115/USO1, preventingtethering of COPI vesicles and thereby inhibiting transportthrough the Golgi apparatus during mitosis (By similarity). Alsoplays a key role in spindle pole assembly and centrosomeorganization (PubMed:26165940). Promotes the mitotic spindle poleassembly by activating the spindle assembly factor TPX2 tonucleate microtubules around the Golgi and capture them to couplemitotic membranes to the spindle: upon phosphorylation at theonset of mitosis, GOLGA2 interacts with importin-alpha via thenuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assemblyfactor TPX2 from importin-alpha. TPX2 then activates AURKA kinaseand stimulates local microtubule nucleation. Upon filamentassembly, nascent microtubules are further captured by GOLGA2,thus linking Golgi membranes to the spindle (PubMed:19242490,PubMed:26165940). Regulates the meiotic spindle pole assembly,probably via the same mechanism (By similarity). Also regulatesthe centrosome organization (PubMed:18045989, PubMed:19109421).Also required for the Golgi ribbon formation and glycosylation ofmembrane and secretory proteins (PubMed:16489344,PubMed:17314401). {ECO:0000250|UniProtKB:Q62839,ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344,ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989,ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490,ECO:0000269|PubMed:26165940}. | ATP-dependent lipophilic drug transporter.{ECO:0000269|PubMed:12379217}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GOLGA2_ABCA8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GOLGA2_ABCA8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GOLGA2_ABCA8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GOLGA2_ABCA8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ABCA8 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
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