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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14977

FusionGeneSummary for GNL3_ARHGAP9

check button Fusion gene summary
Fusion gene informationFusion gene name: GNL3_ARHGAP9
Fusion gene ID: 14977
HgeneTgene
Gene symbol

GNL3

ARHGAP9

Gene ID

26354

64333

Gene nameG protein nucleolar 3Rho GTPase activating protein 9
SynonymsC77032|E2IG3|NNP47|NS10C|RGL1
Cytomap

3p21.1

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein-like 3E2-induced gene 3 proteinestradiol-induced nucleotide binding proteinguanine nucleotide binding protein-like 3 (nucleolar)novel nucleolar protein 47nucleolar GTP-binding protein 3nucleosteminrho GTPase-activating protein 9rho-type GTPase-activating protein 9
Modification date2018052320180523
UniProtAcc

Q9BVP2

Q9BRR9

Ensembl transtripts involved in fusion geneENST00000418458, ENST00000394799, 
ENST00000460073, 
ENST00000393791, 
ENST00000356411, ENST00000424809, 
ENST00000393797, ENST00000550288, 
ENST00000430041, ENST00000550454, 
Fusion gene scores* DoF score7 X 8 X 4=2244 X 4 X 4=64
# samples 84
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNL3 [Title/Abstract] AND ARHGAP9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGNL3

GO:0017145

stem cell division

25522312


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA545728GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000418458ENST00000393791GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000418458ENST00000356411GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000418458ENST00000424809GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000418458ENST00000393797GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000418458ENST00000550288GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000418458ENST00000430041GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000418458ENST00000550454GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000393791GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000356411GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000424809GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000393797GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000550288GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000430041GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000394799ENST00000550454GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000393791GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000356411GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000424809GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000393797GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000550288GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000430041GNL3chr3

52724838

+ARHGAP9chr12

57881851

+
intron-intronENST00000460073ENST00000550454GNL3chr3

52724838

+ARHGAP9chr12

57881851

+

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FusionProtFeatures for GNL3_ARHGAP9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNL3

Q9BVP2

ARHGAP9

Q9BRR9

May be required to maintain the proliferative capacityof stem cells. Stabilizes MDM2 by preventing its ubiquitination,and hence proteasomal degradation (By similarity). {ECO:0000250,ECO:0000269|PubMed:12464630, ECO:0000269|PubMed:16012751}. GTPase activator for the Rho-type GTPases by convertingthem to an inactive GDP-bound state. Has a substantial GAPactivity toward CDC42 and RAC1 and less toward RHOA. Has a role inregulating adhesion of hematopoietic cells to the extracellularmatrix. Binds phosphoinositides, and has the highest affinity forphosphatidylinositol 3,4,5-trisphosphate, followed byphosphatidylinositol 3,4-bisphosphate and phosphatidylinositol4,5-bisphosphate. {ECO:0000269|PubMed:11396949}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNL3_ARHGAP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNL3_ARHGAP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNL3_ARHGAP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNL3_ARHGAP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARHGAP9C0010073Coronary Artery Vasospasm1CTD_human
TgeneARHGAP9C0023893Liver Cirrhosis, Experimental1CTD_human